C型凝集素受体通路

C型凝集素受体(CLRs)是一系列可溶性和跨膜蛋白构成的蛋白家族,主要结合基于碳水化合物的病原体相关分子模式(PAMPs),包括海藻糖6’,6’-二聚叶酸(TDM)、脂阿拉伯甘露聚糖(LAM)、脂甘露聚糖 (LM)和磷脂酰肌醇甘露糖苷(PIMS)。CLRs与这些PAMPs的相互作用并诱导细胞内信号转导,触发细胞因子的产生及诱导适应性免疫反应。此外,一些CLRs可以被自身损伤信号激活。
基于信号转导的方式和能力,CLRs可以进一步被细分为免疫感受器酪氨酸激活基序(ITAM)偶联的CLRs、间接携带ITAM的CLRs、免疫感受器酪氨酸抑制基序(ITIM)包含的CLRs和一组缺乏典型信号基序的CLRs。通过位于这些受体胞浆部分的ITAM样基序,ITAM偶联的CLRs可以直接诱导细胞内信号,而间接携带ITAM的CLRs可以通过受体偶联的接头分子(如FcRγ或DAP12)带有的ITAM间接诱导细胞内信号转导。通过这两种机制偶联的信号转导都涉及到Syk,活化的Syk会造成PLCγ2激活和ROS的产生。PLCγ2将细胞膜磷脂PIP2切割成二级信使IP3和DAG,导致PKCδ和Ca2+信号级联的激活。PKCδ激活将促进CARD9、Bcl10和Malt1形成复合体。这种复合体将导致几个下游分子的激活,包括NF-κB、多种MAPK、ASC和Caspase-8。Ca2+信号级联包括钙调神经磷酸酶依赖的NF-AT激活,它与NF-κB和多种MAPK协同调节基因转录和细胞反应,包括细胞吞噬、DC成熟、细胞趋化、呼吸爆发、炎症激活、细胞因子和其他介质的产生。由ROS诱导的NLRP3炎症小体和CARD9/Bcl10/Malt1招募的caspase-8将将IL-1β和IL-18的前体切割为成熟形式,以诱导抗真菌免疫中的保护作用。Dectin-1信号通路也诱导Ras-GRF1的Syk依赖性激活,它通过CARD9接头蛋白招募H-Ras,并最终导致ERK激活。对于含有ITIM的CLRs,他们将招募蛋白酪氨酸磷酸酶SHP1/2来抑制几种TLRs介导的NF-kB激活和下游效应。此外,多种证据表明,CLRs会与其他PRRs(特别是TLRs)协同作用,实现最佳的微生物识别和免疫监控。

ABclonal针对C型凝集素受体通路研究,提供以下常见核心靶点的产品

Caveolin-1 Rabbit mAb

PKC delta Rabbit mAb

Phospho-PLC gamma 1 (PLCG1)-S1248 Rabbit pAb

IKKβ Rabbit mAb

Phospho-Raf1-S621 Rabbit mAb

ERK1/2 Rabbit mAb

Phospho-ERK1-T202 + ERK2-T185 Rabbit mAb

CLR信号通路精选研究产品

分类
研究靶点 产品货号 产品名称 应用 物种
CLR家族成员
CLEC4DA2697CLEC4D Rabbit pAbELISA,WB,IF/ICCHuman, Mouse, Rat
CD209A9649CD209 Rabbit mAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
MRC1A11192Mannose Receptor/CD206 Rabbit mAbELISA,WBHuman, Mouse
FCER2A11436CD23 Rabbit mAbELISA,WB,IF/ICCHuman, Rat
CLEC10AA11859CD301/CLEC10A Rabbit pAbELISA,WBHuman, Mouse
CLEC12AA6250CLEC12A Rabbit pAbELISA,WBHuman, Mouse, Rat
信号转导分子
SYKA2123Syk Rabbit pAbELISA,WB,IF/ICCHuman, Mouse, Rat
SYKAP0542Phospho-Syk-Y525/526 Rabbit pAbELISA,WBHuman
SYKAP0291Phospho-Syk-Y323 Rabbit pAbWB,IF/ICCHuman
PLCG1A8899PLC gamma 1 (PLCG1) Rabbit mAbELISA,WBHuman, Mouse, Rat
PLCG2A5182PLC gamma 2 (PLCG2) Rabbit mAbELISA,WB,IF/ICCHuman, Mouse, Rat
PLCG1AP0827Phospho-PLC gamma 1 (PLCG1)-S1248 Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
PLCG1AP1340Phospho-PLC gamma 1 (PLCG1)-Y783 Rabbit mAbELISA,WBMouse
PLCG1AP0164Phospho-PLC gamma 1 (PLCG1)-Y783 Rabbit pAbELISA,WBHuman, Mouse
PLCG2AP0785Phospho-PLC gamma 2 (PLCG2)-Y759 Rabbit pAbELISA,WBHuman
PLCG2AP0805Phospho-PLC gamma 2 (PLCG2)-Y1217 Rabbit pAbELISA,WB,IHC-PHuman, Mouse
PRKCDAP0496Phospho-PKC delta-Y311 Rabbit pAbELISA,WBHuman, Mouse
PRKCDAP0972Phospho-PKC delta-S645 Rabbit pAbELISA,WBHuman, Mouse, Rat
PRKCDAP0776Phospho-PKC delta-T505 Rabbit pAbELISA,WBHuman
RAF1A19638Raf1 Rabbit mAbELISA,WB,IPHuman, Mouse, Rat
RAF1AP1012Phospho-Raf1-S259 Rabbit mAbELISA,WBHuman, Rat
RAF1AP0498Phospho-Raf1-S338 Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
RAF1AP1011Phospho-Raf1-S621 Rabbit mAbELISA,WBHuman, Rat
CHUKA19694IKKα Rabbit mAbELISA,WBHuman, Mouse
IKBKBA19606IKKβ Rabbit mAbELISA,IF/ICCHuman, Mouse, Rat
CHUK/IKBKBAP0546Phospho-IKKα/β-S176/180 Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
IKBKEA3463IKKε Rabbit mAbELISA,WB,IHC-PHuman, Mouse, Rat
MAPK1/MAPK3A4782ERK1/2 Rabbit mAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
MAPK1/MAPK3A10613ERK1 / ERK2 Mouse mAbELISA,WBHuman,Mouse, Rat
MAPK1/MAPK3A16686ERK1 / ERK2 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
MAPK1/MAPK3AP0974Phospho-ERK1-T202/Y204 + ERK2-T185/Y187 Rabbit mAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
ERK1/ERK2AP0485Phospho-ERK1-T202 + ERK2-T185 Rabbit mAbELISA,WB,IHC-PHuman, Mouse, Rat
MAPK14A4771[KO Validated] p38 MAPK Rabbit mAbELISA,WBHuman, Mouse, Rat
MAPK14A5049p38 MAPK Rabbit mAbELISA,WB,IF/ICCHuman, Mouse, Rat
MAPK14AP1311Phospho-p38 MAPK-T180/Y182 Rabbit mAbELISA,WBHuman, Mouse, Rat
MAPK14AP0526Phospho-p38 MAPK-T180/Y182 Rabbit pAbELISA,WB,IF/ICCHuman, Mouse, Rat
MAPK8/MAPK9/MAPK10A4867JNK1/2/3 Rabbit mAbELISA,WB,IF/ICCHuman, Mouse, Rat
MAPK8/MAPK9AP0473Phospho-JNK1/2-T183/Y185 Rabbit pAbELISA,WBHuman, Mouse, Rat
MAPK8/MAPK9/MAPK10AP0631Phospho-JNK1/2/3-T183/T183/T221 Rabbit mAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
转录因子
RELAA10609NF-kB p65/RelA Mouse mAbELISA,WB,IF/ICCHuman, Mouse, Rat
RELAA18210NF-kB p65/RelA Mouse mAbELISA,WB,IF/ICCHuman, Mouse, Rat
RELAA19653NF-kB p65/RelA Rabbit mAbELISA,WB,IHC-P,IF/ICC,ChIPHuman, Mouse, Rat, Monkey
RELAAP1294Phospho-NF-kB p65/RelA-S536 Rabbit mAbELISA,WBHuman,Mouse,Rat
RELAAP0124Phospho-NF-kB p65/RelA-S536 Rabbit pAbELISA,WB,IF/ICCHuman, Mouse, Rat
JUNA11378c-Jun Rabbit pAbELISA,WBHuman, Mouse, Rat
JUNAP0105Phospho-c-Jun-S63 Rabbit mAbELISA,WB,IF/ICCHuman, Mouse, Rat
JUNAP1003Phospho-c-Jun-T91 Rabbit mAbELISA,WB,IHC-PHuman, Mouse, Rat
NFATC1A19597NFAT2 Rabbit mAbELISA,WBHuman
NFATC1A1539NFAT2 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
NFATC2A3107NFATC2 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
NFATC3A6666NFATC3 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
NFATC4A17511NFATC4 Rabbit pAbELISA,WBHuman, Mouse
  • 缩略语注释:
  • FcRγ, Fc Receptor γ‐chain
  • DAP12, DNAX-activation protein 12
  • Syk, spleen tyrosine kinase
  • PLCγ2, phospholipase C gamma 2
  • ROS, reactive oxygen species
  • PIP2, phosphatidylinositol 4,5-bisphosphate
  • IP3, inositol triphosphate
  • DAG, Diacylglycerol
  • PKCδ, Protein kinase C‐δ
  • CARD9, caspase recruitment domain family member 9
  • Bcl10B cell lymphoma 10
  • Malt1, mucosa‐associated lymphoid tissue lymphoma translocation protein 1
  • ASC, apoptosis‐associated speck‐like protein containing a CARD
  • NF-AT, nuclear factor of activated T cells
  • NF-κB, nuclear factor kappa light chain enhancer of activated B cell
  • MAPK, mitogen-activated protein kinase
  • DC, dendritic cells
  • NLRP3, NOD-, LRR- and pyrin domain-containing protein 3
  • Ras-GRF1, Ras protein specific guanine nucleotide releasing factor 1
  • ERK, extracellular signal-regulated protein kinase
  • PRR, pathogen recognition receptor
  • TLR, Toll-like receptor
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  • 2.Viruses. (2017) 9(3). pii: E59.
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  • 6.Am J Pathol. (2015) 185(1):17-25.
  • 7.J Exp Med. (2014) 211(11):2307-21.