Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss - PMC
Journal
Signal transduction and targeted therapy
Young LINE-1 transposon 5 UTRs marked by elongation factor ELL3 function as enhancers to regulate nave pluripotency in embryonic stem cells
Journal
Nature cell biology
DOCK2 regulates antifungal immunity by regulating RAC GTPase activity
Journal
Cellular & molecular immunology
Super-enhancer-controlled positive feedback loop BRD4/ERα–RET–ERα promotes ERα-positive breast cancer
Journal
Nucleic acids research
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy - PMC
Journal
Nature communications
eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content - PMC
Species
Homo sapiens, Mus musculus
Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling - PMC
Interacting with luteinizing hormone receptor provides a new elucidation of the mechanism of anti-androgenicity of bisphenol S
Genome-scale screening in a rat haploid system identifies Thop1 as a modulator of pluripotency exit
Journal
Cell proliferation
Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss - PMC
Journal
Cell communication and signaling : CCS
Moringa oleifera leaf attenuate osteoporosis in ovariectomized rats by modulating gut microbiota composition and MAPK signaling pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Cordycepin inhibits myogenesis via activating the ERK1/2 MAPK signalling pathway in C2C12 cells
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate
Journal
Journal of Translational Medicine
Chlorothalonil exposure compromised mouse oocyte in vitro maturation through inducing oxidative stress and activating MAPK pathway
Journal
Ecotoxicology and environmental safety
JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin
Journal
Ecotoxicology and environmental safety
Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-B/NLRP3 pathways
Journal
Biochimica et biophysica acta. Molecular basis of disease
Loss of PR55α promotes proliferation and metastasis by activating MAPK/AKT signaling in hepatocellular carcinoma
Pimpinellin ameliorates macrophage inflammation by promoting RNF146mediated PARP1 ubiquitination
Journal
Phytotherapy research : PTR
Icariin reduces Glu‐induced excitatory neurotoxicity via antioxidative and antiapoptotic pathways in SH‐SY5Y cells
Journal
Phytotherapy research : PTR
Royal jelly from different floral sources possesses distinct wound-healing mechanisms and ingredient profiles
The preventive effect and underlying mechanism of Rhus chinensis Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice
Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 (CXCL13) in Hyperplastic Prostate - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens,Rattus norvegicus
N-3, a novel synthetic derivative of bifendate, inhibits metastasis of triple-negative breast cancer via decreasing p38-regulated FOXC1 protein stability
Journal
Biochemical pharmacology
Species
Homo sapiens, Mus musculus
Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis
Theaflavin-3,3-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells - PMC
Journal
Frontiers in pharmacology
ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway
Journal
Frontiers in cardiovascular medicine
Species
Homo sapiens,Rattus norvegicus
Inhibitory effect of daphnetin on the C48/80-induced pseudo-allergic reaction
Journal
International immunopharmacology
Puerarin improves diabetic wound healing via regulation of macrophage M2 polarization phenotype - PMC
The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo
Journal
Journal of ethnopharmacology
Preclinical Studies of Chiauranib Show It Inhibits Transformed Follicular Lymphoma through the VEGFR2/ERK/STAT3 Signaling Pathway - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier
Epimedii Folium and Curculiginis Rhizoma ameliorate lipopolysaccharides-induced cognitive impairment by regulating the TREM2 signaling pathway
Analysis of pharmacodynamic components, targets and synergistic action mechanism of Fuyuan Shenghua granule for the treatment of medical-induced incomplete
Journal
Journal of ethnopharmacology
Notoginsenoside R1 protects against hypobaric hypoxia-induced high-altitude pulmonary edema by inhibiting apoptosis via ERK1/2-P90rsk-BAD ignaling pathway
Journal
European journal of pharmacology
Discovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling - PMC
Journal
Scientific reports
Cepharanthine Exerts Antioxidant and Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Macrophages and DSS-Induced Colitis Mice - PMC
Journal
Molecules (Basel, Switzerland)
Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo
Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development - PMC
Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway
Journal
Toxicology and applied pharmacology
Species
Mus musculus,Rattus norvegicus
Developmental toxicity window of fetal testicular injury in offspring mice induced by prenatal amoxicillin exposure at different time, doses and courses
Journal
Toxicology letters
Suppression of mir-1505p attenuates the anti-inflammatory effect of glucocorticoids in mice with ulcerative colitis
Journal
Molecular immunology
Tectoridin alleviates caerulein-induced severe acute pancreatitis by targeting ERK2 to promote macrophage M2 polarization
Journal
Archives of biochemistry and biophysics
RAF1 mediates the FSH signaling pathway as a downstream molecule to stimulate estradiol synthesis and secretion in mouse ovarian granulosa cells
Journal
Annals of translational medicine
LNC00115 Mediates Cisplatin Resistance by Regulating the miR-7/ERK Signalling Pathway in Ovarian Cancer
TPI1 promotes MAPK/ERKinduced EMT, cell migration and invasion in lung adenocarcinoma
Autophagy inhibition mediated by trillin promotes apoptosis in hepatocellular carcinoma cells via activation of mTOR/STAT3 signaling
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic Inflammation - PMC
Novel Indolyl-Benzimidazole Compounds Promote in vitro Wound Healing and Osteogenic Differentiation of Pluripotent Cells
Journal
Frontiers in bioscience (Landmark edition)
Mifepristone increases AQP1 mRNA expression, angiogenesis, and cell permeability through the ERK MAPK pathway
Journal
Molecular biology reports
Antipharyngitis Effects of Syringa oblata L. Ethanolic Extract in Acute Pharyngitis Rat Model and Anti-Inflammatory Effect of Ir-Idoids in LPS-Induced RAW 264.7 Cells
Journal
Evid Based Complement Alternat Med
NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Prognostic and Immune Infiltration Analysis of Transaldolase 1 (TALDO1) in Hepatocellular Carcinoma - PMC
Journal
International journal of general medicine
Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction - PMC
Journal
Cell death & disease
Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes - PMC
Journal
Open medicine (Warsaw, Poland)
The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling - PMC
Journal
Cell death & disease