Recombinant protein (or fragment).This information is considered to be commercially sensitive.
克隆号
ARC5141-01
产品形式
Liquid
偶联物
ABflo® 647. Ex:648nm. Em:664nm.
克隆号
ARC5141-01
产品形式
Liquid
偶联物
ABflo® 647. Ex:648nm. Em:664nm.
细胞定位
Cell membrane, Single-pass type I membrane protein.
存储缓冲液
Store at 2-8℃. Avoid freeze. Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Usihng ABflo® 488 Rabbit anti-Human/Monkey CD4 and ABflo® 647 Rabbit anti-Human HLA-DR monoclonal antibody for flow cytometry analysis of human PBMCs, the results showed a clear separation of cell populations.
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
