RIG-I-MAVS 信号通路

作为首要的胞浆RNA监测机制,RIG-I-MAVS信号通路被作为一种抗病毒感染的天然免疫保护系统受到深入研究 [1]。RIG-I样受体(RLRs),包括RIG-I、MDA5和LGP2,是检测病毒感染或复制过程中积累的多种病毒RNA的一系列胞浆RNA解旋酶 [2]。在除pDCs以外的大多数细胞类型中,RLRs对于抗病毒反应是必不可少的。 RIG-I和MDA5表现出不同的配体特异性,并对不同的病毒作出反应,而LGP2促进或拮抗MDA5和RIG-I对病毒RNA的识别 [3]。进一步的研究还发现了其他病毒感受器,如OAS1,它是干扰素诱导下可以被dsRNA激活的抗病毒分子酶,在细胞天然抗病毒反应中起着至关重要的作用。这种蛋白质激活潜在的RNaseL,从而导致病毒RNA降解和抑制病毒复制 [4]。
当RIG-I或MDA5识别其配体时,它与位于线粒体外膜的MAVS蛋白迅速结合。 MAVS作为RLR信号传递的核心接头蛋白,在控制下游信号传递中发挥作用。二聚化的MAVS直接招募TRAF2、TRAF3、TRAF5、TRAF6、CARD9和TRADD等分子,作为在线粒体外膜组装信号复合物的平台[5]。这些信号复合体包含由TRAFs或TRADD进一步招募的其他多种蛋白,包括CIAP1/2、TANK-NAP1-Tbkbp1、TAB2/3-TAB1-TAK1、TBK1-IK Kε、IK Kα-IK Kβ-IK Kγ、和RIP1-FADD-Casp8-Casp10 [6]。通过这些信号复合体,RIG-I-MAVS信号级联最终导致IR F3,IRF7,NF-κB和AP-1的磷酸化和激活,它们共同作用于诱导干扰素和促炎细胞因子的表达。与许多信号通路一样,RIG-I-MAVS信号通路也存在精密的调控方式来实现信号的平衡,包括信号蛋白的翻译后修饰(如泛素化、磷酸化修饰)调节或竞争性蛋白相互作用[7]。此外,RIG-I-MAVS信号通路还会与cGAS-STING[8]、炎症小体[9]和自噬[10,11]等多条信号通路发生串话,增加了RIG-I-MAVS信号调节和功能的复杂性。

ABclonal针对RIG-I-MAVS 信号通路研究,提供以下常见核心靶点的产品

COX5B Rabbit pAb

Rig-I/DDX58 Rabbit pAb

TRAF2 Rabbit pAb

Phospho-NF-kB p65/RelA-S536 Rabbit mAb

SMURF2 Rabbit mAb

IRF3 Rabbit pAb

TBK1/NAK Rabbit mAb

Phospho-TBK1/NAK-S172 Rabbit mAb

RIG-I-MAVS信号通路精选研究产品

分类
研究靶点 产品货号 产品名称 应用 物种
胞浆RNA感受器
RIGIA18003[KO Validated] Rig-I/DDX58 Rabbit pAbELISA,WB,IF/ICCHuman, Mouse
RIGIA13407Rig-I/DDX58 Rabbit pAbELISA,WB,IF/ICCHuman, Mouse, Rat
IFIH1A2419MDA5 Rabbit mAbELISA,WBHuman, Mouse, Rat
DHX58A8257DHX58 Rabbit pAbELISA,WB,IF/ICCHuman, Mouse, Rat
OAS1A2530OAS1 Rabbit pAbELISA,WBHuman, Mouse
RNASELA9840RNASEL Rabbit pAbELISA,WBHuman, Mouse, Rat
信号转导分子
MAVSA5764MAVS Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
TRAF2A0962TRAF2 Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
TRAF3A3094TRAF3 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
TRAF6A16991TRAF6 Rabbit pAbELISA,WB,IF/ICCHuman, Mouse, Rat
TANKA6763TANK Rabbit pAbELISA,WBHuman, Mouse, Rat
TraddA1145TRADD Rabbit pAbELISA,WBHuman, Mouse
TBK1A3458TBK1/NAK Rabbit mAbELISA,WB,IF/ICC,IPHuman, Mouse, Rat
TBK1AP1026Phospho-TBK1/NAK-S172 Rabbit mAbELISA,WBHuman, Mouse
CHUKA19694IKKα Rabbit mAbELISA,WBHuman, Mouse
IKBKBA19606IKKβ Rabbit mAbELISA,IF/ICCHuman, Mouse, Rat
CHUK/IKBKBAP0546Phospho-IKKα/β-S176/180 Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
IKBKEA3463IKKε Rabbit mAbELISA,WB,IHC-PHuman, Mouse, Rat
转录因子
IRF3A11118IRF3 Rabbit pAbELISA,WB,IHC-P,IF/ICC,ChIP,IPHuman, Mouse, Rat
IRF3A19717[KO Validated] IRF3 Rabbit mAbELISA,WBHuman, Mouse
IRF3AP0995Phospho-IRF3-S386 Rabbit mAbELISA,WBHuman
IRF3AP0623Phospho-IRF3-S396 Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
IRF7A0159IRF7 Rabbit pAbELISA,WBMouse
RELAA19653NF-kB p65/RelA Rabbit mAbELISA,WB,IHC-P,IF/ICC,ChIPHuman, Mouse, Rat, Monkey
RELAA10609NF-kB p65/RelA Mouse mAbELISA,WB,IF/ICCHuman, Mouse, Rat
RELAAP1294Phospho-NF-kB p65/RelA-S536 Rabbit mAbELISA,WBHuman,Mouse,Rat
RELAAP0475Phospho-NF-kB p65/RelA-S536 Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
信号通路调节分子
NLRX1A18065[KO Validated] NLRX1 Rabbit pAbELISA,WBHuman, Mouse, Rat
COX5BA2640COX5B Rabbit pAbELISA,WB,IHC-P,IF/ICC,IPHuman, Mouse, Rat
PSMA7A4052PSMA7 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
SMURF2A2278SMURF2 Rabbit mAbELISA,WB,IHC-P,IF/ICC,IPHuman, Mouse
PCBP1A19276hnRNP E1/PCBP1 Rabbit mAbELISA,WBHuman, Mouse, Rat
PCBP1A22141hnRNP E1/PCBP1 Rabbit mAbELISA,WBHuman, Mouse
PCBP1A1044hnRNP E1/PCBP1 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
PCBP2A2531hnRNP E2/PCBP2 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
PCBP2A21119hnRNP E2/PCBP2 Rabbit mAbELISA,WB,IPHuman, Mouse, Rat
  • 缩略语注释:
  • RIG-I, retinoic acid-inducible gene
  • MAVS,mitochondrial antiviral signaling
  • MDA5, melanoma differentiation associated gene 5
  • LGP2, laboratory of genetics and physiology 2
  • PAMP, pathogen-associated molecular patterns
  • pDCs, plasmacytoid dendritic cells
  • TRAF,TNF-receptor-associated factor
  • CARD9,caspase recruitment domain family member 9
  • TRADD, tumor necrosis factor receptor type 1-associated death domain
  • cIAP1/2, cellular inhibitor of apoptosis 1 and 2
  • TANK, TRAF Family Member Associated NFKB Activator
  • NAP1, NAK-associated protein 1
  • Tbkbp1, TBK1 binding protein 1
  • TAK,TGF-beta activated kinase
  • TAB, TAK1-associated binding protein 2
  • TBK, TANK binding kinase
  • IKK, inhibitor of nuclear factor kappa B kinase
  • RIPK1, receptor-interacting serine/threonine-protein kinase 1
  • FADD, Fas-associated protein with death domain
  • IRF, interferon regulatory factor
  • PCBP, poly(RC)-binding protein
  • Smurf2, smad ubiquitin regulatory factor 2
  • 参考文献:
  • 1.Front Immunol. (2014) 5: 342.
  • 2.Curr Opin Virol. (2015) 12: 91-98.
  • 3.Immunity. (2011) 34(5): 680–692.
  • 4.Nucleic Acids Res. (2015) 43(10): 5236-5248.
  • 5.J Mol Biol. (2013) 425(24):5009-5019.
  • 6.J Mol Signal. (2013) 8: 7.
  • 7.Eur J Immunol. (2017) 47(4):615-628.
  • 8.Trends Immunol. (2017) 38(3): 194-205.
  • 9.Curr Opin Virol. (2011) 1(3): 167-176.
  • 10.Cell Discov.(2016) 2:16024.
  • 11.Front Immunol. (2018) 9: 2096.