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Western blot analysis of extracts from parental (Control) and ELAVL1 knockout (KO) 293T cells, using ELAVL1 antibody (A1608) at 1:1000 dilution.
Genome sequence analysis of PCR products from parental (WT) and ELAVL1 knockout (KO) 293T cells, using sanger sequencing.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
