NF-κB信号通路

NF-κB是一个高度保守的多功能转录因子家族,包含五个成员,分别为p65(RelA)、RelB、c-Rel、NF-κB1和NF-κB2,它们会组成不同的同源或异源二聚体而发挥基因转录调节作用,进而调节许多重要的细胞行为,特别是炎症反应、应激反应、细胞生长、细胞存活和凋亡[1]。与其他家族成员不同的是,NF-κB1和NF-κB2被合成为前体(p105和p100),并分别可以被加工成p50和p52[2]。在大多数静止细胞中,这些二聚体的转录调节活性受到NF-κB抑制分子(IκB)的限制,或在加工为成熟形式前受其自身内部抑制基序的限制(比如p105或p100)。当细胞受到各种刺激,含有IKKα、IKKβ和IKKγ(NF-κB必需调节物,也称为NEMO)的IκB激酶复合物可以被多种上游信号通路激活,并介导IκB的磷酸化和蛋白酶体降解。然后NF-κB同源或异源二聚体可以转移到细胞核并激活靶基因转录[2]。NF-κB激活的另一种途径,也被称为替代途径,在包括BAFFR、CD40、RANK或LTβR的下游存在,导致NF-κB诱导激酶(NIK)活化并激活IKKα[3]。IKKα能磷酸化p100并导致p100的多泛素化及其随后经蛋白酶体被加工为p52。然后,p52-RelB二聚体可以激活靶基因的转录。除了上述两种激活途径,NF-κB还可以在特定情况下被其他信号通路或激酶激活,称为非典型激活途径 [4]。NF-κB转录调控系统的复杂性也体现在如下几个方面:1)不同的NF-κB二聚体对DNA结合序列的变化有不同的偏好。因此,不同的靶基因由不同的NF-κB二聚体在不同程度上被激活[5]; 2)NF-κB家族成员和调节因子还含有磷酸化和其他翻译后修饰的位点,这些位点对NF-κB的调节和与其他信号通路的串话很重要[4,6];3)在不同的细胞环境下,NF-κB信号通路与其他信号通路之间或NF-κB与其他转录因子之间的串话,增加了NF-κB调控和功能的复杂性 [2, 7-14]。

ABclonal针对NF-κB信号通路研究,提供以下常见核心靶点的产品

NF-kB p65/RelA Rabbit mAb

Phospho-NF-kB p65/RelA-S536 Rabbit mAb

IκBα Rabbit mAb

NFKB1 Rabbit pAb

IKKβ Rabbit mAb

IKKε Rabbit mAb

NF-κB2 Rabbit mAb

NF-κB信号通路精选研究产品

分类
研究靶点 产品货号 产品名称 应用 物种
NF-κB家族成员
RELAA19653NF-kB p65/RelA Rabbit mAbELISA,WB,IHC-P,IF/ICC,ChIPHuman, Mouse, Rat, Monkey
RELAA10609NF-kB p65/RelA Mouse mAbELISA,WB,IF/ICCHuman, Mouse, Rat
RELAAP1294Phospho-NF-kB p65/RelA-S536 Rabbit mAbELISA,WBHuman,Mouse,Rat
RELAAP0124Phospho-NF-kB p65/RelA-S536 Rabbit pAbELISA,WB,IF/ICCHuman, Mouse, Rat
RELAAP0123Phospho-NF-kB p65/RelA-S276 Rabbit pAbELISA,WBHuman, Mouse, Rat
RELAAP0445Phospho-NF-kB p65/RelA-S311 Rabbit pAbELISA,WBHuman, Mouse
RELAAP0446Phospho-NF-kB p65/RelA-S468 Rabbit pAbELISA,WBHuman, Rat
RELAAP0838Phospho-NF-kB p65/RelA-T435 Rabbit pAbELISA,WBHuman, Mouse
RELAAP0944Phospho-NF-kB p65/RelA-S529 Rabbit pAbELISA,WBHuman, Mouse, Rat
RELAA18210NF-kB p65/RelA Mouse mAbELISA,WB,IF/ICCHuman, Mouse, Rat
RELBA0519RELB Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
NFKB1A6667NFKB1 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
NFKB1AP0125Phospho-NFKB1-S337 Rabbit pAbELISA,WBHuman, Mouse, Rat
NFKB1AP0416Phospho-NFKB1-S907 Rabbit pAbWBHuman
NFKB1AP0264Phospho-NFKB1-S927 Rabbit pAbELISA,WBHuman
NFKB1AP0417Phospho-NFKB1-S932 Rabbit pAbWBHuman, Mouse, Rat
NFKB2A19605NF-κB2 Rabbit mAbELISA,WB,IHC-PHuman, Mouse, Rat
NFKB2A18039[KO Validated] NF-κB2 Rabbit pAbELISA,WBHuman, Mouse
NFKB2AP0418Phospho-NF-κB2-S866 Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse
NFKB2AP0419Phospho-NF-κB2-S870 Rabbit pAbWBHuman
NF-κB调节分子
NFKBIAA11168IκBα Rabbit pAbELISA,WBMouse, Rat
NFKBIAA19714IκBα Rabbit mAbELISA,WB,IHC-PHuman, Mouse, Rat
NFKBIAAP0707Phospho-IκBα-S32 Rabbit mAbELISA,WBHuman, Mouse, Rat
NFKBIAAP0999Phospho-IκBα-S36 Rabbit mAbELISA,WB,IHC-PHuman, Mouse, Rat
NFKBIAAP1069Phospho-IκBα-S36 Rabbit pAbELISA,WBHuman, Mouse, Rat
NFKBIAAP0420Phospho-IκBα-Y42 Rabbit pAbWBHuman
CHUKA19694IKKα Rabbit mAbELISA,WBHuman, Mouse
CHUKAP0505Phospho-IKKα-S176 Rabbit pAbELISA,WBHuman, Mouse, Rat
CHUKAP0506Phospho-IKKα-S180 Rabbit pAbELISA,WBHuman, Mouse
IKBKBA19606IKKβ Rabbit mAbELISA,IF/ICCHuman, Mouse, Rat
IKBKEA3463IKKε Rabbit mAbELISA,WB,IHC-PHuman, Mouse, Rat
IKBKEA0244IKKε Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
IKBKEA14093IKKε Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
IKBKGA12536[KO Validated] IKKγ Rabbit pAbELISA,WB,IPHuman, Mouse
IKBKGA0917IKKγ Rabbit pAbELISA,WB,IHC-P,IF/ICCHuman, Mouse, Rat
IKBKGAP1111Phospho-IKKγ-S376 Rabbit pAbELISA,WBHuman, Mouse, Rat
CHUK/IKBKBAP0546Phospho-IKKα/β-S176/180 Rabbit pAbELISA,WB,IHC-PHuman, Mouse, Rat
  • 缩略语注释:
  • NF-κB, nuclear factor kappa light chain enhancer of activated B cells
  • IKK, inhibitor of nuclear factor kappa B kinase
  • BAFFR, B cell activation factor
  • RANK, receptor activator for nuclear factor kappa B
  • LTβR, lymphtoxin β-receptor
  • NIK, NF-κB-inducing kinase
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