产品描述
LY294002 是一种广谱 PI3K 抑制剂，抑制 PI3Kα, PI3Kδ 和 PI3Kβ 的 IC50 分别为 0.5, 0.57, 0.97 μM。LY294002 也可抑制 CK2 的活性，IC50 为 98 nM。LY294002 是一种竞争性 DNA-PK 抑制剂，可逆结合 DNA-PK 的激酶结构域，IC50 为 1.4 μM。LY294002 是一种凋亡 (apoptosis) 激活剂。
产品参数
别名
LY 294002; NSC 697286; SF 1101
保存条件
Store at -20℃. This product is stable at -20℃ up to 3 years from the date of receipt .
After reconstitution, the solution is stable at -20℃ for 6 months, at -80℃ for up to 1 year.
操作方法
Ethanol: 10 mg/mL (32.5 mM)
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.4 mg/mL (11.06 mM), Working solution is recommended to be prepared and used immediately.
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 61.46 mg/mL (200 mM), Sonication is recommended.
生物活性
细胞实验
DNA-PK:1.4 μM (cell free), p110δ:0.57 μM (cell free), p110β:0.97 μM (cell free), p110α:0.5 μM (cell free)
溶解度信息
