Recombinant Macaca mulatta IL-10 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser19-Asn178) of Macaca mulatta IL-10 (Accession #NM_001044727.1.) fused with no tag .
Macaca mulatta IL-10,Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation .In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
