Recombinant Human CEACAM5/CEA/CD66e (145-322) Protein was determined by Tris-Bis PAGE under reducing conditions.
The purity of Human CEACAM-5 (145-322) is greater than 95% as determined by SEC-HPLC.
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated.
