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* This package insert must be read in its entirety before using this product.
Human Complement Factor D Sandwich ELISA Immunoassay
Recommended Concentration | Sample | |
---|---|---|
ELISA Capture | 0.5-2ug/mL | Rabbit anti-Human Complement Factor D mAb(CAP)(Cat. No.RMK0176) |
ELISA Detection | 0.033-0.133ug/mL | Rabbit anti-Human Complement Factor D mAb(DET)(Cat. No.RMK0177) |
Standard | 7.81-500pg/mL | Recombinant Human Complement Factor D Protein(Cat. No.RP01367) |
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease.