Brown-fat-mediated tumour suppression by cold-altered global metabolism - PMC
Mouse totipotent stem cells captured and maintained through spliceosomal repression
ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
Monkeypox virus quadrivalent mRNA vaccine induces immune response and protects against vaccinia virus - PMC
Journal
Signal transduction and targeted therapy
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis - PMC
Journal
Signal transduction and targeted therapy
ALKBH3-dependent m 1 A demethylation of Aurora A mRNA inhibits ciliogenesis
Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta2C Modified with Chondroitin Sulfate (TACS)
Journal
Advanced materials (Deerfield Beach, Fla.)
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival
Journal
Cell host & microbe
Young LINE-1 transposon 5 UTRs marked by elongation factor ELL3 function as enhancers to regulate nave pluripotency in embryonic stem cells
Journal
Nature cell biology
Arabidopsis ECAP Is a New Adaptor Protein that Connects JAZ Repressors with the TPR2 Co-repressor to Suppress Jasmonate-Responsive Anthocyanin Accumulation
Species
Arabidopsis thaliana
Arabidopsis SYP121 acts as an ROP2 effector in the regulation of root hair tip growth
Species
Arabidopsis thaliana
SADSCoV nsp1 inhibits the IFN production by preventing TBK1 phosphorylation and inducing CBP degradation
Journal
Journal of medical virology
Antiviral and anti‐inflammatory activity of natural compounds against Japanese encephalitis virus via inhibition of NS5 protein and regulation of key immune and …
Journal
Journal of medical virology
Species
Cricetulus migratorius
ASF1 regulates asexual and sexual reproduction in Stemphylium eturmiunum by DJ-1 stimulation of the PI3K/AKT signaling pathway
Species
Stemphylium eturmiunum
PLK3 facilitates replication of swine influenza virus by phosphorylating viral NP protein
Journal
Emerging microbes & infections
Species
Homo sapiens,Sus scrofa
Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis
Journal
Brain, behavior, and immunity
Species
Homo sapiensMus musculus
Ribosomal frameshifting at normal codon repeats recodes functional chimeric proteins in human
Journal
Nucleic acids research
Cyclic di-GMP inhibits nitrate assimilation by impairing the antitermination function of NasT in Pseudomonas putida
Journal
Nucleic acids research
Species
Pseudomonas putida
A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Journal
Nature communications
Species
Homo sapiens, Mus musculus
Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division.
Journal
Nature Communications
Species
Drosophila melanogaster
Par complex cluster formation mediated by phase separation
Journal
Nature Communications
Species
Drosophila melanogaster
The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Journal
Nature communications
Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
Journal
Nature Communications
The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division
Journal
Nature Communications
ATG14 targets lipid droplets and acts as an autophagic receptor for syntaxin18-regulated lipid droplet turnover - PMC
Journal
Nature communications
Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation - PMC
Journal
Nature communications
Species
Homo sapiens, Mus musculus
The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells - PMC
Journal
Nature communications
mRNA vaccine quality analysis using RNA sequencing - PMC
Journal
Nature communications
Single-cell RNA-seq uncovers dynamic processes orchestrated by RNA-binding protein DDX43 in chromatin remodeling during spermiogenesis - PMC
Journal
Nature communications
An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment - PMC
Journal
Nature communications
Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling - PMC
Journal
Nature communications
Multi-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy - PMC
Journal
Nature communications
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway
Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Yin Yang 1Induced Long Noncoding RNA DUXAP9 Drives the Progression of Oral Squamous Cell Carcinoma by Blocking CDK1Mediated EZH2 Degradation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Species
Homo sapiens, Mus musculus
Creating Polyploid Escherichia Coli and Its Application in Efficient LThreonine Production
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ProteinNanocaged Selenium Induces t (8; 21) Leukemia Cell Differentiation via Epigenetic Regulation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Immunogenic Nanovesicle-Tandem-Augmented Chemoimmunotherapy via Efficient Cancer-Homing Delivery and Optimized Ordinal-Interval Regime - PMC
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Mitochondrial Transfer Regulates Cell Fate Through Metabolic Remodeling in Osteoporosis
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer - PMC
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 …
Telomeric TERB1-TRF1 interaction is crucial for male meiosis
Journal
Nature structural & molecular biology
The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor
A dopamine-precursor-based nanoprodrug for in-situ drug release and treatment of acute liver failure by inhibiting NLRP3 inflammasome and facilitating liver regeneration
Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGasSting Axis in Spinal Cord Injury
A Biallelic Frameshift Mutation in Nephronectin Causes Bilateral Renal Agenesis in Humans
Journal
Journal of the American Society of Nephrology : JASN
Mitochondrial C1qbp promotes differentiation of effector CD8 + T cells via metabolic-epigenetic reprogramming
Collagen hydrogel viscoelasticity regulates MSC chondrogenesis in a ROCK-dependent manner - PMC
Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation - PMC
Journal
EMBO molecular medicine
Species
Homo sapiensMus musculusRattus norvegicus
Mediation of the JNC/ILC2 pathway in DBP-exacerbated allergic asthma: A molecular toxicological study on neuroimmune positive feedback mechanism
Journal
Journal of hazardous materials
Daucosterol confers protection against T-2 toxin induced blood-brain barrier toxicity through the PGC-1-mediated defensive response in vitro and in vivo
Journal
Journal of hazardous materials
Coronaviral ORF6 protein mediates interorganelle contacts and modulates host cell lipid flux for virus production
Interleukin-1α leads to growth hormone deficiency in adamantinomatous craniopharyngioma by targeting pericytes: implication in pituitary fibrosis
Journal
Metabolism: clinical and experimental
Species
Homo sapiens,Rattus norvegicus
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics
Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer
Megakaryocytes mediate hyperglycemia-induced tumor metastasis
Species
Homo sapiens, Mus musculus
ERF9 of Poncirus trifoliata (L.) Raf. undergoes feedback regulation by ethylene and modulates cold tolerance via regulating a glutathione S-transferase U17 gene.
Journal
Plant biotechnology journal
Lipid transfer protein StLTPa enhances potato disease resistance against different pathogens by binding and disturbing the integrity of pathogens plasma membrane
Journal
Plant biotechnology journal
Genetic variation in ZmKW1 contributes to kernel weight and size in dent corn and popcorn
Journal
Plant biotechnology journal
Ustilaginoidea virenssecreted effector Uv1809 suppresses rice immunity by enhancing OsSRT2mediated histone deacetylation
Journal
Plant biotechnology journal
Potato protein tyrosine phosphatase StPTP1a is activated by StMKK1 to negatively regulate plant immunity
Journal
Plant biotechnology journal
Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation
Journal
Molecular Therapy : the Journal of the American Society of Gene Therapy
The transcription factor PbbHLH164 is destabilized by PbRAD23C/D. 1 and mediates ethylene biosynthesis during pear fruit ripening
Journal
Journal of advanced research
DMP8 and 9 regulate HAP2/GCS1 trafficking for the timely acquisition of sperm fusion competence
Journal
Proceedings of the National Academy of Sciences of the United States of America
Original research: Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis - PMC
Journal
Journal for immunotherapy of cancer
Species
Homo sapiens, Mus musculus
A coiled-coil protein associates Polycomb Repressive Complex 2 with KNOX/BELL transcription factors to maintain silencing of cell differentiation-promoting genes in the shoot apex
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer
An electroporation strategy to synthesize the membrane-coated nanoparticles for enhanced anti-inflammation therapy in bone infection
Nanotechnology-mediated immunochemotherapy with ingenol-3-mebutate for systematic anti-tumor effects
Journal
Journal of controlled release : official journal of the Controlled Release Society
Rational preparation and application of a mRNA delivery system with cytidinyl/cationic lipid
Decreased miR-214–3p activates NF-κB pathway and aggravates osteoarthritis progression.
An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons and 1 in HBV infection by promoting MAVS lysosomal degradation
Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer.
Journal
Journal of experimental & clinical cancer research
LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification
Journal
J Exp Clin Cancer Res .
An LRH-RSL4 feedback regulatory loop controls the determinate growth of root hairs in Arabidopsis
Journal
Current biology : CB
Species
Arabidopsis thaliana
Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis
Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species - PMC
Meta-data analysis of kidney stone disease highlights ATP1A1 involvement in renal crystal formation
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner - PMC
Effects of triclosan exposure on stem cells from human exfoliated deciduous teeth (SHED) fate
Journal
The Science of the total environment
AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis - PMC
Journal
International journal of biological sciences
Ambient NO2 exposure induces migraine in rats: Evidence, mechanisms and interventions
Journal
The Science of the total environment
Maternally derived low glucocorticoid mediates adrenal developmental programming alteration in offspring induced by dexamethasone
Journal
The Science of the total environment
DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53
Journal
International journal of biological sciences
Dynamics of the gut-liver axis in rats with varying fibrosis severity
Journal
International journal of biological sciences
Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis.
Journal
International journal of biological sciences
Alginate oligosaccharide structures differentially affect DSS-induced colitis in mice by modulating gut microbiota
Journal
Carbohydrate polymers
Sulfate oligosaccharide of Gracilaria lemaneiformis modulates type 1 immunity by restraining T cell activation
Journal
Carbohydrate polymers
Distinguished biomimetic dECM system facilitates early detection of metastatic breast cancer cells
Journal
Bioengineering & translational medicine
A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury
Journal
Acta Biomaterialia
Nanoparticle-dsRNA Treatment of Pollen and Root Systems of Diseased Plants Effectively Reduces the Rate of Tobacco Mosaic Virus in Contemporary Seeds
Journal
ACS applied materials & interfaces
GLUT-Targeting Phototherapeutic Nanoparticles for Synergistic Triple Combination Cancer Therapy
Journal
ACS applied materials & interfaces
Bioinspired Nanospheres as Anti-inflammation and Antisenescence Interfacial Biolubricant for Treating Temporomandibular Joint Osteoarthritis
Journal
ACS applied materials & interfaces
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy
Journal
Science China. Life sciences
A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells
Journal
Science China. Life sciences
Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis
Sex difference in adrenal developmental toxicity induced by dexamethasone and its intrauterine programming mechanism
Journal
Pharmacological research
Species
Rattus norvegicus, Homo sapiens
A Meloidogyne incognita C‐type lectin effector targets plant catalases to promote parasitism
Journal
The New phytologist
Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial
Journal
Clinical immunology (Orlando, Fla.)
Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis.
Journal
Mol Ther Nucleic Acids
Cardiac miR-19a/19b was induced and hijacked by CVB3 to facilitate virus replication via targeting viral genomic RdRp-encoding region
Journal
Antiviral research
In vitro and in vivo effects of 3-indoleacetonitrile—A potential new broad-spectrum therapeutic agent for SARS-CoV-2 infection - PMC
Journal
Antiviral research
The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer - PMC
Journal
NPJ precision oncology
DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
Coordination of tumor growth and host wasting by tumor-derived Upd3
Species
Drosophila melanogaster
Dibutyl phthalate exposure disrupts the progression of meiotic prophase I by interfering with homologous recombination in fetal mouse oocytes.
Journal
Environmental pollution (Barking, Essex : 1987)
Involvement of TLRs/NF-B/ESE-1 signaling pathway in T-2 toxin-induced cartilage matrix degradation
Journal
Environmental pollution (Barking, Essex : 1987)
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy - PMC
NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer
MORTALIN-Ca 2+ axis drives innate rituximab resistance in diffuse large B-cell lymphoma
SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation.
ERβ promotes Aβ degradation via the modulation of autophagy.
Journal
Cell Death & Disease
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma - PMC
Journal
Cell death & disease
Species
Homo sapiensMus musculus
The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission - PMC
MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC - PMC
FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis
Cancer-associated dynamics and potential regulators of intronic polyadenylation revealed by IPAFinder using standard RNA-seq data
Two-dimensional nanovermiculite and polycaprolactone electrospun fibers composite scaffolds promoting diabetic wound healing - PMC
Journal
Journal of nanobiotechnology
Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit α1 promote hydroxylation and secretion of type I collagen.
Journal
Cellular and molecular life sciences
Sertoli cell survival and barrier function are regulated by miR-181c/d-Pafah1b1 axis during mammalian spermatogenesis - PMC
Journal
Cellular and molecular life sciences : CMLS
Species
Mus musculus、Sus scrofa
The rice Raf‐like MAPKKK OsILA1 confers broad‐spectrum resistance to bacterial blight by suppressing the OsMAPKK4–OsMAPK6 cascade
Journal
J Integr Plant Biol
Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch
Glaesserella parasuis QseBC two-component system senses epinephrine and regulates capD expression
Journal
Microbiology spectrum
TurboID Screening of the OmpP2 Protein Reveals Host Proteins Involved in Recognition and Phagocytosis of Glaesserella parasuis by iPAM Cells
Journal
Microbiology spectrum
Enrofloxacin (ENR) exposure induces lipotoxicity by promoting mitochondrial fragmentation via dephosphorylation of DRP1 at S627 site
Zinc attenuates sulfamethoxazole-induced lipotoxicity by reversing sulfamethoxazole-induced mitochondrial dysfunction and lysosome impairment in a freshwater teleost
A Signaling Pathway to Mediate the Combined Immunomodulation of Acetylcholine and Enkephalin in Oyster Crassostrea gigas
Journal
Frontiers in Immunology
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke
Journal
Frontiers in immunology
HSC70 Inhibits Spring Viremia of Carp Virus Replication by Inducing MARCH8-Mediated Lysosomal Degradation of G Protein
Porcine Beta-Defensin 2 Provides Protection Against Bacterial Infection by a Direct Bactericidal Activity and Alleviates Inflammation via Interference With the TLR4/NF-κB Pathway.
Journal
Frontiers in Immunology
TRIM67 Suppresses TNFalpha-Triggered NF-kB Activation by Competitively Binding Beta-TrCP to IkBa
Journal
Frontiers in immunology
Inducing enhanced neutralizing antibodies against broad SARS-CoV-2 variants through glycan-shielding multiple non-neutralizing epitopes of RBD - PMC
Journal
Frontiers in immunology
B602L-Fc fusion protein enhances the immunogenicity of the B602L protein of the African swine fever virus - PMC
Journal
Frontiers in immunology
Species
Spodoptera frugiperdaMus musculus
MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome - PMC
Journal
Frontiers in immunology
Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells - PMC
Journal
Frontiers in immunology
Virus-like particles containing a prefusion-stabilized F protein induce a balanced immune response and confer protection against respiratory syncytial virus infection in mice - PMC
Journal
Frontiers in immunology
A metabolite attenuates neuroinflammation, synaptic loss and cognitive deficits induced by chronic infection of Toxoplasma gondii
- PMC
Journal
Frontiers in immunology
Characterization of a novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae and its role in regulating mice immune cell response - PMC
Journal
Frontiers in immunology
Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME - PMC
Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma
Journal
Clinical and translational medicine
Species
Homo sapiens, Mus musculus
Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies - PMC
Journal
Clinical and translational medicine
Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease - PMC
Journal
Journal of translational medicine
CircESRP1 enhances metastasis and epithelial-mesenchymal transition in endometrial cancer via the miR-874-3p/CPEB4 axis
Journal
Journal of translational medicine
CENPA promotes clear cell renal cell carcinoma progression and metastasis via Wnt/β-catenin signaling pathway
Metabolomics-based molecular signatures reveal the toxic effect of co-exposure to nitrosamines in drinking water
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment
Journal
Diabetes research and clinical practice
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis
Journal
Free radical biology & medicine
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis
Journal
Free radical biology & medicine
Competition between two phosphatases fine-tunes Hedgehog signaling
Species
Drosophila melanogaster
The Cdc42 GAP Rga6 promotes monopolar outgrowth of spores
Journal
The Journal of cell biology
Species
Saccharomyces cerevisiae
Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways
Journal
Journal of medicinal chemistry
Dual Nicotinamide Phosphoribosyltransferase (NAMPT) and Indoleamine 2, 3-Dioxygenase 1 (IDO1) Inhibitors for the Treatment of Drug-Resistant Nonsmall-Cell …
Journal
Journal of medicinal chemistry
Polysaccharide from flammuliana velutipes improves colitis via regulation of colonic microbial dysbiosis and inflammatory responses
Journal
International Journal of Biological Macromolecules
MYST family histone acetyltransferases regulate reproductive diapause initiation
Journal
International journal of biological macromolecules
NPFR regulates the synthesis and metabolism of lipids and glycogen via AMPK: Novel targets for efficient corn borer management
Journal
International journal of biological macromolecules
A soluble TLR5 is involved in PBLs activation and antibacterial immunity via TLR5M-MyD88-signaling pathway in tongue sole Cynoglossus semilaevis
Journal
International journal of biological macromolecules
Species
Cynoglossus (Arelia) semilaevis
Depletion of LOXL2 improves respiratory capacity: From air-breathing fish to mammal under hypoxia
Journal
International journal of biological macromolecules
Chinese yam polysaccharides PLGA-stabilized Pickering emulsion as an adjuvant system for PCV-2 vaccine to enhance immune response
Journal
International journal of biological macromolecules
A pattern recognition receptor ficolin from Portunus trituberculatus (Ptficolin) regulating immune defense and hemolymph coagulation
Journal
International journal of biological macromolecules
Species
Portunus trituberculatus
CD36 as a Molecular Target of Functional DNA Aptamer NAFLD01 Selected against NAFLD Cells
Protist ubiquitin ligase effector PbE3-2 targets cysteine protease RD21A to impede plant immunity
The Auxin response factor TaARF15-A1 negatively regulates senescence in common wheat (Triticum aestivum L.)
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H2O2-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway
Journal
Antioxidants (Basel, Switzerland)
Dietary Stevioside Supplementation Alleviates Lipopolysaccharide-Induced Intestinal Mucosal Damage through Anti-Inflammatory and Antioxidant Effects in Broiler Chickens
Journal
Antioxidants (Basel, Switzerland)
miR-135a Suppresses Granulosa Cell Growth by Targeting Tgfbr1 and Ccnd2 during Folliculogenesis in Mice
Parkin-Dependent Mitophagy Is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells
APN Expression in Serum and Corpus Luteum: Regulation of Luteal Steroidogenesis Is Possibly Dependent on the AdipoR2/AMPK Pathway in Goats
Activated Lymphocyte-Derived DNA Drives Glucose Metabolic Adaptation for Inducing Macrophage Inflammatory Response in Systemic Lupus Erythematosus - PMC
Silencing of circCacna1c Inhibits ISO-Induced Cardiac Hypertrophy through miR-29b-2-5p/NFATc1 Axis - PMC
Species
Cricetulus griseus
The Efficacy of HGF/VEGF Gene Therapy for Limb Ischemia in Mice with Impaired Glucose Tolerance: Shift from Angiogenesis to Axonal Growth and Oxidative Potential in Skeletal Muscle - PMC
Synergism of Feeding and Digestion Regulated by the Neuropeptide F System in Ostrinia furnacalis Larvae - PMC
Species
Ostrinia furnacalis
A polymeric nanoformulation improves the bioavailability and efficacy of sorafenib for hepatocellular carcinoma therapy
Journal
Biomaterials science
Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome
Journal
Cell communication and signaling : CCS
GETV nsP2 plays a critical role in the interferon antagonism and viral pathogenesis - PMC
Journal
Cell communication and signaling : CCS
Species
Homo sapiens, Mus musculus
GPR65 inhibits human trophoblast cell adhesion through upregulation of MYLK and downregulation of fibronectin via cAMP-ERK signaling in a low pH environment - PMC
Journal
Cell communication and signaling : CCS
Slc2a6 regulates myoblast differentiation by targeting LDHB - PMC
Journal
Cell communication and signaling : CCS
Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication
The PRMT5/WDR77 complex restricts hepatitis E virus replication
Aal-circRNA-407 regulates ovarian development of Aedes albopictus, a major arbovirus vector, via the miR-9a-5p/Foxl axis
Aspergillus fumigatus Elongator complex subunit 3 affects hyphal growth, adhesion and virulence through wobble uridine tRNA modification - PMC
Transcription factor 7-like 2 controls matrix degradation through nuclear factor B signaling and is repressed by microRNA-155 in nucleus pulposus cells
Journal
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
Species
Homo sapiens, Rattus norvegicus
Protective effects of dioscin against cartilage destruction in a monosodium iodoacetate (MIA)-indcued osteoarthritis rat model
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Potentilla discolor ameliorates LPS-induced inflammatory responses through suppressing NF-κB and AP-1 pathways
Journal
Biomed Pharmacother
Ozone pretreatment alleviates ischemiareperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Lactobacillus casei ATCC 393 combined with vasoactive intestinal peptide alleviates dextran sodium sulfate-induced ulcerative colitis in C57BL/6 mice via NF
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Species
Lacticaseibacillus case
NHWD-1062 ameliorates inflammation and proliferation by the RIPK1/NF-κB/TLR1 axis in Psoriatic Keratinocytes
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Microalga Chlorella sp. extract induced apoptotic cell death of cholangiocarcinoma via AKT/mTOR signaling pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Species
Chlorocebus sabaeus
Patchouli Alcohol Inhibits D-Gal Induced Oxidative Stress and Ameliorates the Quality of Aging Cartilage via Activating the Nrf2/HO-1 Pathway in Mice - PMC
Journal
Oxidative medicine and cellular longevity
Patchouli Alcohol Inhibits D-Gal Induced Oxidative Stress and Ameliorates the Quality of Aging Cartilage via Activating the Nrf2/HO-1 Pathway in Mice - PMC
Journal
Oxidative medicine and cellular longevity
Ca2+-dependent nuclease is involved in DNA degradation during the formation of the secretory cavity by programmed cell death in fruit of Citrus grandis 'Tomentosa'
Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation
Journal
Clinical epigenetics
Species
Homo sapiens, Mus musculus
Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage
Journal
Acta pharmacologica Sinica
Regulation of apoptosis by Pacific oyster Crassostrea gigas reveals acclimation strategy to CO 2 driven acidification
Journal
Ecotoxicol Environ Saf
Aluminum-maltol induced oxidative stress and reduced AMPK activity via BCK-related energy supply failure in C6 cell
Journal
Ecotoxicology and environmental safety
JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin
Journal
Ecotoxicology and environmental safety
Paneth cells protect intestinal stem cell niche to alleviate deoxynivalenol-induced intestinal injury
Journal
Ecotoxicology and environmental safety
Metformin alleviates nickel-refining fumes-induced aerobic glycolysis via AMPK/GOLPH3 pathway in vitro and in vivo
Journal
Ecotoxicology and environmental safety
Ozone causes depressive-like response through PI3K/Akt/GSK3β pathway modulating synaptic plasticity in young rats
Journal
Ecotoxicology and environmental safety
Metabolomic transition trajectory and potential mechanisms of N-nitrosomethylbenzylamine induced esophageal squamous cell carcinoma in rats
Journal
Ecotoxicology and environmental safety
Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway - PMC
Journal
Cell death discovery
Long noncoding RNA NONMMUT015745 inhibits doxorubicin-mediated cardiomyocyte apoptosis by regulating Rab2A-p53 axis - PMC
Journal
Cell death discovery
Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis - PMC
Journal
Cell death discovery
Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold
Journal
European Journal of Medicinal Chemistry
Discovery of novel nitrogenous heterocyclic-containing quinoxaline-1, 4-di-N-oxides as potent activator of autophagy in M. tb-infected macrophages
Journal
European journal of medicinal chemistry
Design, synthesis and anti-inflammatory evaluation of aloe-emodin derivatives as potential modulators of Akt, NF-κB and JNK signaling pathways
Journal
European journal of medicinal chemistry
CXCR2 antagonism promotes oligodendrocyte precursor cell differentiation and enhances remyelination in a mouse model of multiple sclerosis
Journal
Neurobiology of disease
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO1 pathway
Journal
CNS neuroscience & therapeutics
Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA - PMC
Journal
International journal of nanomedicine
LIPUS‐SCs‐Exo promotes peripheral nerve regeneration in cavernous nerve crush injury‐induced ED rats via PI3K/Akt/FoxO signaling pathway
Journal
CNS neuroscience & therapeutics
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway
Journal
Cell Death Discovery
Species
Homo sapiens, Mus musculus
Temperature-regulated type II grass carp reovirus establishes latent infection in Ctenopharyngodon idella brain
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma
MicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjögren's syndrome
Exosomal miR-218 derived from mesenchymal stem cells inhibits endothelial-to-mesenchymal transition by epigenetically modulating of BMP2 in pulmonary fibrosis
Journal
Cell biology and toxicology
Nanotherapy for bone repair: milk-derived small extracellular vesicles delivery of icariin - PMC
Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway
Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells
MicroRNA-145 overexpression attenuates apoptosis and increases matrix synthesis in nucleus pulposus cells.
p55PIK regulates alpha-fetoprotein expression through the NF-κB signaling pathway
The metabolite saccharopine impairs neuronal development by inhibiting the neurotrophic function of glucose-6-phosphate isomerase
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
A distinct metabolically defined central nucleus circuit bidirectionally controls anxiety-related behaviors
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
S. boulardii Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats - PMC
Astragaloside IV Attenuates Hypoxia-Induced Cardiac Hypertrophy Via Calpain-1-Mediated Mtor Activation
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Species
Mus musculus,Rattus norvegicus
San Huang Xiao Yan recipe modulates the HMGB1-mediated abnormal inflammatory microenvironment and ameliorates diabetic foot by activating the AMPK/Nrf2
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Osthole: a potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway
Journal
Biochim Biophys Acta Mol Basis Dis
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis
Journal
Biochimica et biophysica acta. Molecular basis of disease
ZmPP2C26 Alternative Splicing Variants Negatively Regulate Drought Tolerance in Maize
Journal
Frontiers in plant science
Identification of CDPKs involved in TaNOX7 mediated ROS production in wheat - PMC
Journal
Frontiers in plant science
Histone acetylation functions in the wound-induced spore formation in nori - PMC
Journal
Frontiers in plant science
Intestinal Flora Dysbiosis Aggravates Cognitive Dysfunction Associated With Neuroinflammation in Heart Failure
Journal
Journal of Cardiac Failure
Active fractions of golden-flowered tea (Camellia nitidissima Chi) inhibit epidermal growth factor receptor mutated non-small cell lung cancer via multiple pathways and targets in vitro and in vivo - PMC
Journal
Frontiers in nutrition
Species
Homo sapiens, Mus musculus
Luteolin regulates the distribution and function of organelles by controlling SIRT1 activity during postovulatory oocyte aging - PMC
Journal
Frontiers in nutrition
Attenuator LRR - a regulatory tool for modulating gene expression in Gram-positive bacteria
Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway
Journal
Oxid Med Cell Longev
p38MAPK-and GSK3-Mediated Phosphorylation of Snakehead Vesiculovirus Phosphoprotein at Threonine 160 Facilitates Viral Replication
Journal
Journal of virology
Prohibitin1 facilitates viral replication by impairing the RIG-I-like receptor signaling pathway
Journal
Journal of virology
Micropterus salmoides rhabdovirus enters cells via clathrin-mediated endocytosis pathway in a pH-, dynamin-, microtubule-, rab5-, and rab7-dependent manner
Journal
Journal of virology
Species
Pimephales promelas
Eukaryotic translation elongation factor 1 alpha (eEF1A) inhibits Siniperca chuatsi rhabdovirus (SCRV) infection through two distinct mechanisms
Journal
Journal of virology
Nanopore long-read RNA sequencing reveals functional alternative splicing variants in human vascular smooth muscle cells - PMC
Journal
Communications biology
The Host Protein CAD Regulates the Replication of FMDV through the Function of Pyrimidines De Novo Synthesis - PMC
Journal
Journal of virology
Species
Mesocricetus auratus
Tembusu Virus Nonstructural Protein 2B Antagonizes Type I Interferon Production by Targeting MAVS for Degradation
Journal
Journal of virology
DA7R: A 7-Letter Zip Code to Target PDAC - PMC
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release - PMC
Long noncoding RNA TCL6 binds to miR‐106a‐5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway
Journal
Journal of cellular physiology
Trimethylamine N‐oxide exacerbates acetaminophen‐induced liver injury by interfering with macrophage‐mediated liver regeneration
Transferrin-conjugated liposomes loaded with carnosic acid inhibit liver cancer growth by inducing mitochondria-mediated apoptosis
Journal
International journal of pharmaceutics
CDCA7‐regulated inflammatory mechanism through TLR4/NF‐κB signaling pathway in stomach adenocarcinoma
Journal
BioFactors (Oxford, England)
SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFβ/PI3K/AKT/GSK3β pathway
Journal
Cancer cell international
Gastric cancer cell-originated small extracellular vesicle induces metabolic reprogramming of BM-MSCs through ERK-PPARγ-CPT1A signaling to potentiate lymphatic metastasis - PMC
Journal
Cancer cell international
As a prognostic biomarker of clear cell renal cell carcinoma RUFY4 predicts immunotherapy responsiveness in a PDL1-related manner
Journal
Cancer cell international
Klf4 Promotes Dentinogenesis and Odontoblastic Differentiation via Modulation of TGF‐β Signaling Pathway and Interaction With Histone Acetylation
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomyinduced bone loss
Journal
Phytotherapy research : PTR
Cornuside, by regulating the AGEs‐RAGE‐IκBα‐ERK1/2 signaling pathway, ameliorates cognitive impairment associated with brain aging
Journal
Phytotherapy research : PTR
Baicalin alleviates chronic obstructive pulmonary disease through regulation of HSP72-mediated JNK pathway
Alantolactone induces apoptosis through ROS-mediated AKT pathway and inhibition of PINK1-mediated mitophagy in human HepG2 cells
(−)-Epicatechin gallate blocks the development of atherosclerosis by regulating oxidative stress in vivo and in vitro
microRNA-130b-3p Contained in MSC-Derived EVs Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis
Journal
Mol Ther Oncolytics
Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota
Quercetin as an antiviral agent inhibits the Pseudorabies virus in vitro and in vivo
N-Myc Downstream-Regulated Gene 1 Facilitates Influenza A Virus Replication by Suppressing Canonical NF-κB Signaling
The Slack Channel Deletion Causes Mechanical Pain Hypersensitivity in Mice
Journal
Frontiers in molecular neuroscience
Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats
Journal
Frontiers in molecular neuroscience
Salubrinal Protects Against Cisplatin-Induced Cochlear Hair Cell Endoplasmic Reticulum Stress by Regulating Eukaryotic Translation Initiation Factor 2α Signalling - PMC
Journal
Frontiers in molecular neuroscience
Exercise Normalized the Hippocampal Renin-Angiotensin System and Restored Spatial Memory Function, Neurogenesis, and Blood-Brain Barrier Permeability in the 2K1C-Hypertensive Mouse
Journal
International journal of molecular sciences
Characterization and Interaction Analysis of the Secondary Cell Wall Synthesis-Related Transcription Factor PmMYB7 in Pinus massoniana Lamb
Journal
International journal of molecular sciences
Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia
Journal
International journal of molecular sciences
Icariin Regulates Cellular Functions and Gene Expression of Osteoarthritis Patient-Derived Human Fibroblast-Like Synoviocytes.
Journal
International Journal of Molecular Sciences
N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells.
Journal
International Journal of Molecular Sciences
Ouabain Enhances Cell-Cell Adhesion Mediated by β1 Subunits of the Na+,K+-ATPase in CHO Fibroblasts.
Journal
International Journal of Molecular Sciences
The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells.
Journal
International Journal of Molecular Sciences
BmRRS1 Protein Inhibits the Proliferation of Baculovirus Autographa californica Nucleopolyhedrovirus in Silkworm, Bombyx mori - PMC
Journal
International journal of molecular sciences
Vascular Endothelial Growth Factor A (VEGFA) Regulates Hepatic Lipid and Glycogen Metabolism in Schizothorax prenanti - PMC
Journal
International journal of molecular sciences
Species
Schizothorax prenanti
LvCD14L Acts as a Novel Pattern Recognition Receptor and a Regulator of the Toll Signaling Pathway in Shrimp - PMC
Journal
International journal of molecular sciences
HSP90AB1 Is a Host Factor Required for Transmissible Gastroenteritis Virus Infection - PMC
Journal
International journal of molecular sciences
Effects of the Overexpression of Progesterone Receptors on a Precancer p53 and Rb-Defective Human Fallopian Tube Epithelial Cell Line - PMC
Journal
International journal of molecular sciences
Arginine Expedites Erastin-Induced Ferroptosis through Fumarate - PMC
Journal
International journal of molecular sciences
A Putative Receptor for Ferritin in Mollusks: Characterization of the Insulin-like Growth Factor Type 1 Receptor - PMC
Journal
International journal of molecular sciences
Transcriptomic and Functional Analyses Reveal the Different Roles of Vitamins C, E, and K in Regulating Viral Infections in Maize - PMC
Journal
International journal of molecular sciences
Effect of the Enhanced Production of Chlorophyll b on the Light Acclimation of Tomato - PMC
Journal
International journal of molecular sciences
Species
Lycopersicon esculentum
Short-Term Starvation Weakens the Efficacy of Cell Cycle Specific Chemotherapy Drugs through G1 Arrest - PMC
Journal
International journal of molecular sciences
Inhibition of Oncogenic Src Ameliorates Silica-Induced Pulmonary Fibrosis via PI3K/AKT Pathway - PMC
Journal
International journal of molecular sciences
Retinal Proteomic Analysis in a Mouse Model of Endotoxin-Induced Uveitis Using Data-Independent Acquisition-Based Mass Spectrometry - PMC
Journal
International journal of molecular sciences
Sequence, Expression, and Anti-GCRV Function of the Ferritin from the Grass Carp, Ctenopharyngodon idellus - PMC
Journal
International journal of molecular sciences
A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection
Journal
International journal of molecular sciences
L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail
Journal
Journal Of Nutritional Biochemistry
Gasdermin D promotes hyperuricemia-induced renal tubular injury through RIG-I/caspase-1 pathway - PMC
JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia - PMC
SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation - PMC
Commercial dishes with gelatin-free microstructured inserts for elongated stem cell self-renewal and pluripotency - PMC
Effects of lysate/tissue storage at -80°C on subsequently extracted EVs of epithelial ovarian cancer tissue origins - PMC
GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry - PMC
Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity - PMC
Toxoplasma gondii SAG1 targeting host cell S100A6 for parasite invasion and host immunity
RJT-101, a novel camptothecin derivative, is highly effective in the treatment of melanoma through DNA damage by targeting topoisomerase 1
Journal
Biochemical pharmacology
Characterization of the Dual Functions of LvCrustinVII from Litopenaeus vannamei as Antimicrobial Peptide and Opsonin
Species
Litopenaeus vannamei
Oncolytic Vaccinia Virus Expressing White-Spotted Charr Lectin Regulates Antiviral Response in Tumor Cells and Inhibits Tumor Growth In Vitro and In Vivo
Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape
Journal
Front Cell Dev Biol
Blockage of Autophagic Flux and Induction of Mitochondria Fragmentation by Paroxetine Hydrochloride in Lung Cancer Cells Promotes Apoptosis via the ROS-MAPK Pathway
Journal
Frontiers in Cell and Developmental Biology
Indole Diterpenes from Mangrove Sediment-Derived Fungus Penicillium sp. UJNMF0740 Protect PC12 Cells against 6-OHDA-Induced Neurotoxicity via Regulating the PI3K/Akt Pathway - PMC
Isolation and Characterization of Targeting-HBsAg VNAR Single Domain Antibodies from Whitespotted Bamboo Sharks (Chiloscyllium plagiosum) - PMC
Species
Chiloscyllium plagiosum
Crustin Defense against Vibrio parahaemolyticus Infection by Regulating Intestinal Microbial Balance in Litopenaeus vannamei - PMC
A Comparative Study of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins in Breast Cancer Cells - PMC
Zfp281 Inhibits the Pluripotent-to-Totipotent State Transition in Mouse Embryonic Stem Cells - PMC
Journal
Frontiers in cell and developmental biology
Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Hepatocellular Carcinoma Cells - PMC
Campylobacter jejuni Cytolethal Distending Toxin Induces GSDME-Dependent Pyroptosis in Colonic Epithelial Cells
Journal
Frontiers in cellular and infection microbiology
Nutrient L-Alanine-Induced Germination of Bacillus Improves Proliferation of Spores and Exerts Probiotic Effects in vitro and in vivo
FBS-Derived Exosomes as a Natural Nano-Scale Carrier for Icariin Promote Osteoblast Proliferation.
Journal
Front Bioeng Biotechnol
Fisetin Lowers Streptococcus suis serotype 2 Pathogenicity in Mice by Inhibiting the Hemolytic Activity of Suilysin.
Journal
Frontiers in Microbiology
Porcine Epidemic Diarrhea Virus Infection Subverts Arsenite-Induced Stress Granules Formation - PMC
Journal
Frontiers in microbiology
Species
Chlorocebus aethiops
Analysis of lysine acetylation in tomato spot wilt virus infection in Nicotiana benthamiana - PMC
Journal
Frontiers in microbiology
Efficient and reversible Cas13d-mediated knockdown with an all-in-one lentivirus-vector - PMC
Journal
Frontiers in bioengineering and biotechnology
Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury
Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching
Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer's disease
Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling
Journal
Frontiers in endocrinology
Species
Homo sapiens, Mus musculus
Determination of the Interaction and Pharmacological Modulation of MCHR1 Signaling by the C-Terminus of MRAP2 Protein
Journal
Frontiers in endocrinology
Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring Rats.
Journal
Frontiers in Endocrinology
Reperfusion after hypoxia-ischemia exacerbates brain injury with compensatory activation of the anti-ferroptosis system: based on a novel rat model
Journal
Neural regeneration research
Dysregulated sphingolipid metabolism and autophagy in granulosa cells of women with endometriosis - PMC
Journal
Frontiers in endocrinology
Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats - PMC
Journal
Frontiers in endocrinology
In Vivo Reductionist Approach Identifies miR-15a Protecting Mice From Obesity - PMC
Journal
Frontiers in endocrinology
Ag120-Mediated Inhibition of ASCT2-Dependent Glutamine Transport has an Anti-Tumor Effect on Colorectal Cancer Cells
Journal
Frontiers in pharmacology
Transcriptome Analysis of the Inhibitory Effect of Sennoside A on the Metastasis of Hepatocellular Carcinoma Cells
Apol9a regulates myogenic differentiation via the ERK1/2 pathway in C2C12 cells - PMC
Journal
Frontiers in pharmacology
Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo - PMC
Journal
Frontiers in pharmacology
Anti-oxidative and anti-inflammatory activities of the ethanol extract of edible flower from Chimonanthus praecox - PMC
Journal
Frontiers in pharmacology
Echinacoside Inhibits Osteoclast Function by Down-Regulating PI3K/Akt/C-Fos to Alleviate Osteolysis Caused by Periprosthetic Joint Infection - PMC
Journal
Frontiers in pharmacology
ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer
LncRNA ADAMTS9-AS2 inhibits cell proliferation and decreases chemoresistance in clear cell renal cell carcinoma via the miR-27a-3p/FOXO1 axis.
Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells - PMC
RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma - PMC
mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers
Journal
American Journal of Cancer Research
USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1 - PMC
Journal
American journal of cancer research
Construction and immune efficacy of recombinant pseudorabies virus expressing PrM-E proteins of Japanese encephalitis virus genotype Ι
Isolation and pathogenicity of porcine circovirus type 2 in mice from Guangxi province, China - PMC
Genetic characterization and pathogenicity of a Eurasian avian-like H1N1 swine influenza reassortant virus - PMC
The recombinant Erns and truncated E2-based indirect enzyme-linked immunosorbent assays to distinguishably test specific antibodies against classical swine fever virus and bovine viral diarrhea virus - PMC
Species
Sus scrofa,Bos taurus,Danio rerio
Comparative Study on the Protective Effect of Chlorogenic Acid and 3-(3-Hydroxyphenyl) Propionic Acid against Cadmium-Induced Erythrocyte Cytotoxicity: In Vitro and In Vivo Evaluation
Rhein from Rheum rhabarbarum Inhibits Hydrogen-Peroxide-Induced Oxidative Stress in Intestinal Epithelial Cells Partly through PI3K/Akt-Mediated Nrf2/HO-1 Pathways.
Journal
Journal of agricultural and food chemistry
Astaxanthin Protects against Alcoholic Liver Injury via Regulating Mitochondrial Redox Balance and Calcium Homeostasis
Journal
Journal of agricultural and food chemistry
Rosmarinic Acid Inhibits Platelet Aggregation and Neointimal Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In
Journal
Journal of agricultural and food chemistry
Protein Phosphorylation Induced by Pyruvate Kinase M2 Inhibited Myofibrillar Protein Degradation in Post-Mortem Muscle
Journal
Journal of agricultural and food chemistry
Interaction between TaNOX7 and TaCDPK13 contributes to plant fertility and drought tolerance by regulating ROS production
Journal
Journal of agricultural and food chemistry
Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression
Journal
International Journal of Oncology
Histone lysine demethylase 3B regulates autophagy via transcriptional regulation of GABARAPL1 in acute myeloid leukemia cells
Journal
International journal of oncology
Galectin-1 binds GRP78 to promote the proliferation and metastasis of gastric cancer - PMC
Journal
International journal of oncology
Phospho-Pon binding-mediated fine-tuning of Plk1 activity
Journal
Structure (London, England : 1993)
Species
Drosophila melanogaster
Exosomal circSCMH1/miR-874 ratio in serum to predict carotid and coronary plaque stability - PMC
Journal
Frontiers in cardiovascular medicine
Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide‐induced preeclampsia
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Maternal L‐carnitine supplementation promotes brown adipose tissue thermogenesis of newborn goats after cold exposure
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ADRV 12L: A Ranaviral Putative Rad2 Family Protein Involved in DNA Recombination and Repair
Levistolide A Inhibits PEDV Replication via Inducing ROS Generation
Characterization of Ictalurid herpesvirus 1 Glycoprotein ORF59 and Its Potential Role on Virus Entry into the Host Cells
Species
Ictalurus punctatus
Identification of a B-Cell Epitope in the VP3 Protein of Senecavirus A
A Subunit Vaccine Based on E2 Protein of Atypical Porcine Pestivirus Induces Th2-type Immune Response in Mice.
Virus-like particles of chimeric recombinant porcine circovirus type 2 as antigen vehicle carrying foreign epitopes
Enhancement of SARS-CoV-2 N Antigen-Specific T Cell Functionality by Modulating the Autophagy-Mediated Signal Pathway in Mice - PMC
Enhancement of SARS-CoV-2 N Antigen-Specific T Cell Functionality by Modulating the Autophagy-Mediated Signal Pathway in Mice - PMC
Antiviral Effect of Manganese against Foot-and-Mouth Disease Virus Both in PK15 Cells and Mice - PMC
Species
Mesocricetus auratus
Construction of Attenuated Strains for Red-Spotted Grouper Nervous Necrosis Virus (RGNNV) via Reverse Genetic System - PMC
Species
Mesocricetus auratus
Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson's Disease Model
Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach
Journal
Journal of enzyme inhibition and medicinal chemistry
Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach
Journal
Journal of enzyme inhibition and medicinal chemistry
Exosomal CD44 Transmits Lymph Node Metastatic Capacity Between Gastric Cancer Cells via YAP-CPT1A-Mediated FAO Reprogramming
Journal
Frontiers in oncology
Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC
p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma.
Journal
Frontiers in Oncology
6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1/FAF1 complex dissociation-mediated autophagy
Journal
Int Immunopharmacol
Isodeoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber Linn., inhibits pro-inflammatory mediators' production through both NF-κB and AP-1 pathways in LPS-activated macrophages
Journal
International Immunopharmacology
Inhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy.
Journal
International immunopharmacology
Activation of PPARγ by Curcumin protects mice from ischemia/reperfusion injury induced by orthotopic liver transplantation via modulating polarization of Kupffer cells
Journal
International immunopharmacology
Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction
Journal
International Immunopharmacology
Tim-3 deficiency aggravates cadmium nephrotoxicity via regulation of NF-B signaling and mitochondrial damage
Journal
International immunopharmacology
PCSK9 inhibitor protects against ischemic cerebral injury by attenuating inflammation via the GPNMB/CD44 pathway
Journal
International immunopharmacology
4-octyl itaconate ameliorates alveolar macrophage pyroptosis against ARDS via rescuing mitochondrial dysfunction and suppressing the cGAS/STING pathway
Journal
International immunopharmacology
d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice
Journal
International immunopharmacology
β-Hydroxybutyrate alleviates pyroptosis in MPP+/MPTP-induced Parkinson's disease models via inhibiting STAT3/NLRP3/GSDMD pathway
Journal
International immunopharmacology
Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis
Journal
International immunopharmacology
Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury
Journal
International immunopharmacology
Canagliflozin ameliorates the development of NAFLD by preventing NLRP3-mediated pyroptosis through FGF21-ERK1/2 pathway
Journal
Hepatology communications
Ethanol Alleviates Amyloid-β-Induced Toxicity in an Alzheimer's Disease Model of Caenorhabiditis elegans
Journal
Frontiers in aging neuroscience
Cerebrospinal Fluid from Patients after Craniotomy with the Appearance of Interleukin-6 Storm can Activate Microglia to Damage the Hypothalamic Neurons
Journal
Molecular neurobiology
Isobavachalcone's Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3
Journal
Molecular neurobiology
Chronic stress-induced elevation of melanin-concentrating hormone in the locus coeruleus inhibits norepinephrine production and associated with
Journal
The international journal of neuropsychopharmacology
The Raf‐like kinase Raf36 negatively regulates plant resistance against the oomycete pathogen Phytophthora parasitica by targeting MKK2
Species
Arabidopsis thaliana
Circular RNAcircLRP6 protects cardiomyocyte from hypoxiainduced apoptosis by facilitating hnRNPMmediated expression of FGF9
Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury.
Journal
Journal of molecular medicine (Berlin, Germany)
Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network
α-Humulene inhibits hepatocellular carcinoma cell proliferation and induces apoptosis through the inhibition of Akt signaling
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Hexafluoropropylene oxide trimer acid causes fibrosis in mice liver via mitochondrial ROS/cGAS-STING/NLRP3-mediated pyroptosis
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Effects of prenatal acetaminophen exposure at different stages, doses and courses on articular cartilage of offspring mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Effects of Amoxicillin Exposure at Different Stages, Doses and Course of Pregnancy on Adrenal Development in Fetal Mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Inhibition of IEC-6 Cell Proliferation and the Mechanism of Ulcerative Colitis in C57BL/6 Mice by Dandelion Root Polysaccharides - PMC
Journal
Foods (Basel, Switzerland)
Whole-Cell Biocatalytic Production of Acetoin with an aldC-Overexpressing Lactococcus lactis Using Soybean as Substrate - PMC
Journal
Foods (Basel, Switzerland)
Generation of markerless and multiple-gene knockout in Glaesserella parasuis based on natural transformation and Flp recombinase
Journal
Applied microbiology and biotechnology
Visceral mesenchymal stem cells from type 2 diabetes donors activate triglycerides synthesis in healthy adipocytes via metabolites exchange and cytokines secretion
Journal
International journal of obesity (2005)
Protein acetylation-mediated cross-regulation of acetic acid and ethanol synthesis in the gas-fermenting Clostridium ljungdahlii
Inhibition of soluble epoxide hydrolase alleviates insulin resistance and hypertension via downregulation of SGLT2 in the mouse kidney
Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb·α-adaptin complex.
Journal
Journal of Biological Chemistry
WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex
Journal
The Journal of Biological Chemistry
Barley yellow dwarf Virus-GAV movement protein activating wheat TaATG6-Mediated antiviral autophagy pathway
Journal
Plant physiology and biochemistry : PPB
Application
WB,GST pull-down
Autophagy induced by Vip3Aa has a pro-survival role in Spodoptera frugiperda Sf9 cells
Species
Spodoptera frugiperda
Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-B
Journal
Journal of Immunology (Baltimore, Md. : 1950)
Outer membrane protein OMP76 of Riemerella anatipestifer contributes to complement evasion and virulence by binding to duck complement factor vitronectin - PMC
Species
Spodoptera frugiperda
Interaction of Nmi and IFP35 Promotes Mutual Protein Stabilization and IRF3 and IRF7 Degradation to Suppress Type I IFN Production in Teleost Fish
Journal
Journal of immunology (Baltimore, Md. : 1950)
CRM197-conjugated peptides vaccine of HCMV pp65 and gH induce maturation of DC and effective viral-specific T cell responses - PMC
LECT2 Is a Novel Antibacterial Protein in Vertebrates
Journal
Journal of immunology (Baltimore, Md. : 1950)
Species
Ctenopharyngodon idellus
LECT2 Is a Novel Antibacterial Protein in Vertebrates
Journal
Journal of immunology (Baltimore, Md. : 1950)
Species
Ctenopharyngodon idellus
PHB2 affects the virulence of Vip3Aa to Sf9 cells through internalization and mitochondrial stability
MicroRNA-155 Deficiency in Kupffer Cells Ameliorates Liver Ischemia-Reperfusion Injury in Mice
Administration Routes of Polyethylenimine-Coated PLGA Nanoparticles Encapsulating Angelica Sinensis Polysaccharide Vaccine Delivery System Affect Immune Responses
Journal
Molecular pharmaceutics
DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors
Structural analysis and macrophage activation of a novel β‑glucan isolated from Cantharellus cibarius
lncRNAS56464. 1 as a ceRNA promotes the proliferation of fibroblast‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p
miR?330?5p inhibits H2O2?induced adipogenic differentiation of MSCs by regulating RXRγ.
Journal
International Journal of Molecular Medicine
Necrostatin-1 protects C2C12 myotubes from CoCl2-induced hypoxia.
Journal
International Journal of Molecular Medicine
Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats
Journal
International Journal of Molecular Medicine
Therapeutic potential of a dual mTORC1/2 inhibitor for the prevention of posterior capsule opacification: An in vitro study
Journal
international journal of molecular medicine
Inhibition of HDAC6 alleviates cancer-induced bone pain by reducing the activation of NLRP3 inflammasome - PMC
Journal
International journal of molecular medicine
LY294002 alleviates bone cancer pain by reducing mitochondrial dysfunction and the inflammatory response
Journal
International journal of molecular medicine
Dihydroartemisinin inhibits the activation and proliferation of hepatic stellate cells by regulating miR-29b-3p - PMC
Journal
International journal of molecular medicine
SphK1 promotes development of non‑small cell lung cancer through activation of STAT3
Journal
International journal of molecular medicine
Calpain-1 mediates vascular remodelling and fibrosis via HIF-1α in hypoxia-induced pulmonary hypertension
Journal
Journal of cellular and molecular medicine
Effect of TLR4/MyD88/NF-kB axis in paraventricular nucleus on ventricular arrhythmias induced by sympathetic hyperexcitation in post-myocardial infarction rats
Journal
Journal of cellular and molecular medicine
The deacetylation of Foxk2 by Sirt1 reduces chemosensitivity to cisplatin
Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome
miR-19b controls cardiac fibroblast proliferation and migration
Journal
Journal of Cellular And Molecular Medicine
Anemoside B4 alleviates arthritis pain via suppressing ferroptosis-mediated inflammation - PMC
Journal
Journal of cellular and molecular medicine
Altered polymerase theta expression promotes chromosomal instability in salivary adenoid cystic carcinoma - PMC
Journal
Journal of cellular and molecular medicine
Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop
Journal
American journal of physiology. Cell physiology
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
L-Alanine promotes anti-infectious properties of Bacillus subtilis S-2 spores via the germination receptor gerAA
Journal
Probiotics and antimicrobial proteins
Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
A shell-formation related carbonic anhydrase in Crassostrea gigas modulates intracellular calcium against CO2 exposure: Implication for impacts of ocean acidification on mollusk calcification
Journal
Aquatic Toxicology
Ocean acidification stimulates alkali signal pathway: A bicarbonate sensing soluble adenylyl cyclase from oyster Crassostrea gigas mediates physiological changes induced by CO2 exposure
Journal
Aquatic Toxicology
Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation
Sophoraflavanone M, a prenylated flavonoid from Sophora flavescens Ait., suppresses pro-inflammatory mediators through both NF-κB and JNK/AP-1 signaling pathways in LPS-primed macrophages
Zhenbao pill attenuates hydrogen peroxide-induced apoptosis by inhibiting autophagy in human umbilical vein endothelial cells
Yinning Tablet, a hospitalized preparation of Chinese herbal formula for hyperthyroidism, ameliorates thyroid hormone-induced liver injury in rats: Regulation of mitochondria-mediated apoptotic signals
Journal
Journal of Ethnopharmacology
SOX4 as a potential therapeutic target for pathological cardiac hypertrophy
Journal
European journal of pharmacology
Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway
Journal
European journal of pharmacology
Species
Mus musculus, Rattus norvegicus
Metabolomics-based study of the potential interventional effects of Xiao-Xu-Ming Decoction on cerebral ischemia/reperfusion rats
Journal
Journal of ethnopharmacology
MiR-200b-3p is upregulated in the placental tissues from patients with preeclampsia and promotes the development of preeclampsia via targeting profilin 2
Journal
Cell cycle (Georgetown, Tex.)
Fluoride resistance capacity in mammalian cells involves global gene expression changes associate with ferroptosis
Journal
Chemico-biological interactions
Genistein Sensitizes Human Cholangiocarcinoma Cell Lines to Be Susceptible to Natural Killer Cells - PMC
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65
Journal
Chemico-biological interactions
Downregulation of m6A Methyltransferase in the Hippocampus of Tyrobp -/- Mice and Implications for Learning and Memory Deficits
Journal
Frontiers in neuroscience
KIF2C Is a Novel Prognostic Biomarker and Correlated with Immune Infiltration in Endometrial Cancer
Chronic Testosterone Deficiency Increases Late Inward Sodium Current and Promotes Triggered Activity in Ventricular Myocytes from Aging Male Mice
Journal
American journal of physiology. Heart and circulatory physiology
Angiotensin-Converting Enzyme 2 Potentiates SARS-CoV-2 Infection by Antagonizing Type I Interferon Induction and Its Down-Stream Signaling Pathway - PMC
Amlexanox exerts anti-inflammatory actions by targeting phosphodiesterase 4B in lipopolysaccharide-activated macrophages
Journal
Biochimica et biophysica acta. Molecular cell research
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment
Journal
The Journal of steroid biochemistry and molecular biology
Transcription factors SltA and CrzA reversely regulate calcium homeostasis under calcium-limited conditions
Journal
Applied and environmental microbiology
Species
A. fumigatus strains
UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport
Journal
Scientific Reports
Species
Caenorhabditis Elegans
Network pharmacology combined with experimental verification to explore the potential mechanism of naringenin in the treatment of cervical cancer - PMC
Journal
Scientific reports
A comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristics - PMC
Journal
Scientific reports
Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance
Journal
Reprod Biol Endocrinol
HuNoV Non-Structural Protein P22 Induces Maturation of IL-1β and IL-18 and N-GSDMD-Dependent Pyroptosis through Activating NLRP3 Inflammasome - PMC
A natriuretic peptide molecule from Vigna angularis, VaEG45, confers rust resistance by inhibiting fungal development
Journal
Plant cell reports
Quantitative proteomic and lipidomics analyses of high oil content GmDGAT1-2 transgenic soybean illustrate the regulatory mechanism of lipoxygenase and oleosin
Journal
Plant cell reports
Dioscin Inhibits the Invasion and Migration of Hepatocellular Carcinoma HepG2 Cells by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition.
Structural Characterization of Polysaccharides from Dendrobium officinale and Their Effects on Apoptosis of HeLa Cell Line
Journal
Molecules (Basel, Switzerland)
miR-4687-5p Affects Intracellular Survival of Mycobacterium tuberculosis through Its Regulation of NRAMP1 Expression in A549 Cells - PMC
TMT-Based Proteomics Reveal the Mechanism of Action of Amygdalin against Rheumatoid Arthritis in a Rat Model through Regulation of Complement and Coagulation Cascades - PMC
Journal
Molecules (Basel, Switzerland)
OGT Binding Peptide-Tagged Strategy Increases Protein O-GlcNAcylation Level in E. coli - PMC
Journal
Molecules (Basel, Switzerland)
Teriparatide ameliorates articular cartilage degradation and aberrant subchondral bone remodeling in DMM mice - PMC
Journal
Journal of orthopaedic translation
MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting ROR in nucleus pulposus cells
Journal
Cellular signalling
LukS-PV inhibits the proliferation of hepatocellular carcinoma cells by maintaining FOXO3 stability via the PI3K/AKT signaling pathway
Journal
Cellular signalling
LncRNA CARMN suppresses EMT through inhibiting transcription of MMP2 activated by DHX9 in breast cancer
Journal
Cellular signalling
HDAC1 inhibits beige adipocyte-mediated thermogenesis through histone crotonylation of Pgc1a/Ucp1
Journal
Cellular signalling
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer in Vitro and …
Journal
Journal of natural products
Functional and structural analysis of a novel splice site HMBS variant in a Chinese AIP patient - PMC
Journal
Frontiers in genetics
The Increased Expression of an Engrailed to Sustain Shell Formation in Response to Ocean Acidification
High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal HIF2a/Iron-Metabolism Pathway - PMC
Pan‐cancer analysis of oncogenic role of insulin‐like growth factor‐binding proteins and validation in ovarian cancer
L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway
Journal
Nutrition & metabolism
Effects of OsRCA Overexpression on Rubisco Activation State and Photosynthesis in Maize - PMC
Journal
Plants (Basel, Switzerland)
Up-Regulation Thioredoxin Inhibits Advanced Glycation End Products-Induced Neurodegeneration.
Journal
Cellular physiology and biochemistry
Upregulation of Neuronal Cylindromatosis Expression is Essential for Electroacupuncture-Mediated Alleviation of Neuroinflammatory Injury by Regulating Microglial Polarization in Rats Subjected to Focal Cerebral Ischemia/Reperfusion
Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation - PMC
Identification and in vitro and in vivo validation of the key role of GSDME in pyroptosis-related genes signature in hepatocellular carcinoma - PMC
LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells - PMC
Species
Rattus norvegicus,Bos taurus
Transcriptomic analysis reveals the effects of maternal selenium deficiency on placental transport, hormone synthesis, and immune response in mice
Journal
Metallomics : integrated biometal science
Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice
Journal
Metallomics : integrated biometal science
S-nitrosoglutathione reductase-dependent p65 denitrosation promotes osteoclastogenesis by facilitating recruitment of p65 to NFATc1 promoter
Preparation of the monoclonal antibody against Nile tilapia Igλ and study on the Igλ+ B cell subset in Nile tilapia
Journal
Fish & shellfish immunology
Species
Oreochromis niloticus
PDIA6 involves the thermal stress response of razor clam, Sinonovacula constricta
Journal
Fish & shellfish immunology
Species
Sinonovacula constricta
Expression profile, subcellular localization of MARCH4 and transcriptome analysis of its potential regulatory signaling pathway in large yellow croaker (Larimichthys …
Journal
Fish & shellfish immunology
A fibrinogen-related protein mediates the recognition of various bacteria and haemocyte phagocytosis in oyster Crassostrea gigas
Journal
Fish & shellfish immunology
Molecular characterization of an LRR-only protein gene in Pacific white shrimp Litopenaeus vannamei: Sequence feature, expression pattern, and protein activity
Journal
Fish & shellfish immunology
Functional characterization of a putative lipopolysaccharide-induced TNF-alpha factor (LITAF) from blood clam Tegillarca granosa in innate immunity
Journal
Fish & Shellfish Immunology
Species
Tegillarca granosa
ATG10 (autophagy-related 10) regulates the formation of autophagosome in the anti-virus immune response of pacific oyster (Crassostrea gigas).
Journal
Fish & shellfish immunology
A novel LRR and Ig domain-containing protein could function as an immune effector in Crassostrea gigas.
Journal
Fish & shellfish immunology
Soluble adenylyl cyclase mediates mitochondrial pathway of apoptosis and ATP metabolism in oyster Crassostrea gigas exposed to elevated CO2
Journal
Fish & shellfish Immunology
Identification of a clip domain serine proteinase involved in immune defense in Chinese mitten crab Eriocheir sinensis
Journal
Fish & shellfish Immunology
Crustacean hyperglycemic hormones directly modulate the immune response of hemocytes in shrimp Litopenaeus vannamei
Journal
Fish & shellfish Immunology
The B-cell translocation gene 1 (CgBTG1) identified in oyster Crassostrea gigas exhibit multiple functions in immune response
Journal
Fish & shellfish Immunology
Two novel LRR and Ig domain-containing proteins from oyster Crassostrea gigas function as pattern recognition receptors and induce expression of cytokines
Journal
Fish & shellfish Immunology
Comparative study of two single CRD C-type lectins, CgCLec-4 and CgCLec-5, from pacific oyster Crassostrea gigas
Journal
Fish & shellfish Immunology
Resveratrol protects against deoxynivalenol-induced ferroptosis in HepG2 cells
Liraglutide attenuates gefitinib-induced cardiotoxicity and promotes cardioprotection through the regulation of MAPK/NF-κB signaling pathways
Journal
Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Identification of Fangjihuangqi Decoction as a late-stage autophagy inhibitor with an adjuvant anti-tumor effect against non-small cell lung cancer - PMC
Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling
Oridonin Inhibits Mycobacterium marinum Infection-Induced Oxidative Stress In Vitro and In Vivo - PMC
Journal
Pathogens (Basel, Switzerland)
Loss of Lactate/Proton Monocarboxylate Transporter 4 Induces Ferroptosis via the AMPK/ACC Pathway and Inhibition of Autophagy on Human Bladder Cancer 5637 Cell Line - PMC
Journal
Journal of oncology
Adipose mesenchymal stem cell-derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt/β-catenin signaling in cutaneous wound healing.
Journal
Journal of cellular biochemistry
Circular RNA hsa_circ_0005239 contributes to hepatocellular carcinoma cell migration, invasion, and angiogenesis by targeting the miR‐34a‐5p/PD‐L1 axis
Journal
Cell biology international
Spleen Toxicity of Organophosphorus Flame Retardant TDCPP in Mice and the Related Mechanisms - PMC
LncRNA LINC00460 facilitates the proliferation and metastasis of renal cell carcinoma via PI3K/AKT signaling pathway - PMC
Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET
Journal
Toxicology and applied pharmacology
Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure
Journal
Toxicol Appl Pharmacol
Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid arthritis
Journal
Toxicology and Applied Pharmacology
Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS3
Journal
Toxicology and Applied Pharmacology
Activation of PPAR-β/δ Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model
Journal
Neurochemical Research
Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
Journal
Psychopharmacology
Resveratrol Attenuated Manganese-Induced Learning and Memory Impairments in Mice Through PGC-1Alpha-Mediated Autophagy and Microglial M1/M2 …
Journal
Neurochemical research
Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion
Journal
The Journal of pharmacology and experimental therapeutics
Amphetamine-induced Neurite Injury in PC12 Cells Through Inhibiting GAP-43 Pathway
Creatine ameliorates high-fat diet-induced obesity by regulation of lipolysis and lipophagy in brown adipose tissue and liver
HSP90 Inhibitor Ganetespib (STA-9090) Inhibits Tumor Growth in c-Myc-Dependent Esophageal Squamous Cell Carcinoma
Journal
Oncotargets and Therapy
Malus micromalus Makino phenolic extract preserves hepatorenal function by regulating PKC-α signaling pathway and attenuating endoplasmic reticulum stress in lead (II) exposure mice
Journal
Journal of Inorganic Biochemistry
Species
Mus musculus,Malus micromalus
Prion Protein Protects Cancer Cells against Endoplasmic Reticulum Stress Induced Apoptosis.
RNA-Seq-based transcriptomics analysis during the photodynamic therapy of primary cells in secondary hyperparathyroidism
Journal
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis
Journal
Drug Des Devel Ther
Network Pharmacology Analysis of the Mechanisms Underlying the Therapeutic Effects of Yangjing Zhongyu Tang on Thin Endometrium - PMC
Journal
Drug design, development and therapy
Molecular genetic analysis and growth hormone treatment in a three-generation Chinese family with Tricho-rhino-phalangeal syndrome I
Journal
Hormone research in paediatrics
Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo
Journal
Toxicology letters
iTRAQ-Based Proteomics Reveals Potential Anti-Virulence Targets for ESBL-Producing Klebsiella pneumoniae
Journal
Infect Drug Resist
A ferritin nanoparticle vaccine for foot-and-mouth disease virus elicited partial protection in mice
Enhanced protective immunity to CSFV E2 subunit vaccine by using IFN-γ as immunoadjuvant in weaning piglets.
A novel subunit vaccine co-expressing GM-CSF and PCV2b Cap protein enhances protective immunity against porcine circovirus type 2 in piglets
Species
Spodoptera frugiperda
TBC1D21 is an essential factor for sperm mitochondrial sheath assembly and male fertility
Journal
Biology of reproduction
Astragalus polysaccharides combined with simvastatin as an immunostimulant enhances the immune adjuvanticity of oil-in-water emulsion and immune responses in …
Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man
Journal
Biology of reproduction
Efficient mucosal vaccination of a novel classical swine fever virus E2-Fc fusion protein mediated by neonatal Fc receptor
Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells
Vimentin loss promotes cancer proliferation through up-regulating Rictor/AKT/β-catenin signaling pathway
Survivin regulated by autophagy mediates hyperglycemia-induced vascular endothelial cell dysfunction
Journal
Experimental Cell Research
miR-143 Targeting CUX1 to Regulate Proliferation of Dermal Papilla Cells in Hu Sheep
Circ_PIAS1 Promotes the Apoptosis of ALV-J Infected DF1 Cells by Up-Regulating miR-183 - PMC
Effect of CUX1 on the Proliferation of Hu Sheep Dermal Papilla Cells and on the Wnt/β-Catenin Signaling Pathway - PMC
The Effect of EGR1 on the Proliferation of Dermal Papilla Cells - PMC
Expression?and?purification?of?recombinant?ATF-mellitin, a?new?type?fusion?protein?targetingovarian?cancer?cells, in?P.?pastoris
Heptadecanoic acid inhibits cell proliferation in PC‑9 non‑small‑cell lung cancer cells with acquired gefitinib resistance
Platelet‑derived growth factor‑BB mediates pancreatic cancer malignancy via regulation of the Hippo/Yes‑associated protein signaling pathway
PRIMA‑1 met induces autophagy in colorectal cancer cells through upregulation of the mTOR/AMPK‑ULK1‑Vps34 signaling cascade
Platelet-derived growth factor-BB mediates pancreatic cancer malignancy via regulation of the Hippo/Yes-associated protein signaling pathway.
PTEN downregulates WD repeat‑containing protein 66 in salivary adenoid cystic carcinoma.
Downregulation of glucose‑6‑phosphate dehydrogenase by microRNA‑1 inhibits the growth of pituitary tumor cells
GC‑MSC‑derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via fatty acid oxidation metabolic reprogramming mediated by the miR‑5572/6855 …
Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress
Journal
Arch Biochem Biophys
Altered expression of long noncoding RNA MEG3 in the offspring of gestational diabetes mellitus induces impaired glucose tolerance in adulthood
Journal
Acta diabetologica
Biogenic Selenium Nanoparticles Synthesized by Lactobacillus casei ATCC 393 Alleviate Acute Hypobaric Hypoxia-Induced Intestinal Barrier Dysfunction in C57BL/6 …
Journal
Biological trace element research
Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration
The identification of alternative oxidase in intermediate host snails of Schistosoma and its potential role in protecting Oncomelania hupensis against niclosamide-induced stress
Journal
Parasites & vectors
Species
Oncomelania hupensis
Anti-infection roles of miR-155-5p packaged in exosomes secreted by dendritic cells infected with Toxoplasma gondii
Journal
Parasites & vectors
Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens
Selenium relieves oxidative stress, inflammation, and apoptosis within spleen of chicken exposed to mercuric chloride
The function of carnosic acid in lipopolysaccharides-induced hepatic and intestinal inflammation in poultry - PMC
Intrauterine inflammation induced white matter injury protection by fibrinogen-like protein 2 deficiency in perinatal mice
Journal
Pediatric research
Metformin induces M2 polarization via AMPK/PGC-1α/PPAR-γ pathway to improve peripheral nerve regeneration - PMC
Journal
American journal of translational research
Cardioprotection of an IK1 channel agonist on L-thyroxine induced rat ventricular remodeling
Probiotics alleviate cognitive dysfunction associated with neuroinflammation in cardiac surgery.
Journal
American Journal of Translational Research
Schaftoside reduces inflammation in Aspergillus fumigatus keratitis through the inhibition of the TLR4/MyD88 pathway
Validation and bioinformatic analysis of propofol-induced differentially expressed microRNAs in primary cultured neural stem cells
Running Improves Muscle Mass by Activating Autophagic Flux and Inhibiting Ubiquitination Degradation in Mdx Mice
A synthetic peptide AWRK6 ameliorates metabolic associated fatty liver disease: involvement of lipid and glucose homeostasis
Transcriptome analysis of senecavirus A-infected cells: Type I interferon is a critical anti-viral factor
Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer model via activation of the MAPK-JNK/c-Jun signaling pathway
Journal
Molecular and cellular biochemistry
Exosome miRNA-203 promotes M1 macrophage polarization and inhibits prostate cancer tumor progression
Journal
Molecular and cellular biochemistry
TurboID screening of ApxI toxin interactants identifies host proteins involved in Actinobacillus pleuropneumoniae-induced apoptosis of immortalized porcine alveolar macrophages - PMC
Journal
Veterinary research
Species
immortalized porcine alveolar macrophage (iPAM) cells
Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway
Journal
Cell stress & chaperones
Heat-labile enterotoxin enhances F4-producing enterotoxigenic E. coli adhesion to porcine intestinal epithelial cells by upregulating bacterial adhesins and STb enterotoxin - PMC
Journal
Veterinary research
Study on the role and mechanism of β4GalT1 both in vivo and in vitro glioma
Journal
Eur Rev Med Pharmacol Sci
SIPA1 promotes angiogenesis by regulating VEGF secretion in Müller cells through STAT3 activation - PMC
Species
Homo sapiens,Mus musculus
FOXG1 regulates the proliferation and apoptosis of human lung cancer cells - PMC
Melatonin Protects Against Hyperoxia-Induced Apoptosis in Alveolar Epithelial type II Cells by Activating the MT2/PI3K/AKT/ETS1 Signaling Pathway
The NF-κB pathway plays a vital role in rat salivary gland atrophy model - PMC
A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction
A Priori Activation of Apoptosis Pathways of Tumor (AAAPT) technology: Development of targeted apoptosis initiators for cancer treatment
Duhuo Jisheng Decoction regulates intracellular zinc homeostasis by enhancing autophagy via PTEN/Akt/mTOR pathway to improve knee cartilage degeneration - PMC
GSK-3 inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation - PMC
Exosomal miR-133a-3p promotes the growth and metastasis of lung cancer cells following incomplete microwave ablation
Journal
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury
Journal
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells
Journal
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Preparation, characterization and pharmacodynamic study on deep second degree burns of total flavonoids composite phospholipids liposome of Oxytropis falcata Bunge
Journal
Drug Dev Ind Pharm
Platonin Protects Against Cerebral Ischemia/Reperfusion Injury in Rats by Inhibiting NLRP3 Inflammasomes via BNIP3/LC3 Signaling Mediated Autophagy
Inhibition of spastin impairs motor function recovery after spinal cord injury
Journal
Brain research bulletin
Celastrol Alleviates Mitochondrial Oxidative Stress and Brain Injury after Intracerebral Hemorrhage by Promoting OPA1-Dependent Mitochondrial Fusion
OsCSN1 Regulates the Growth and Development of Rice Seedlings through the Degradation of SLR1 in the GA Signaling Pathway
Journal
Journal of plant physiology
Canscora lucidissima, a Chinese folk medicine, exerts anti-inflammatory activities by inhibiting the phosphorylation of ERK1/2 in LPS-activated macrophages
Journal
BMC Complementary and Alternative Medicine
Truncated FRMD7 proteins in congenital Nystagmus: novel frameshift mutations and proteasomal pathway implications - PMC
Journal
BMC medical genomics
Blocking exosomal secretion aggravates 1,4-benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells
Journal
Journal of applied toxicology : JAT
A Carbonic Anhydrase Serves as an Important Acid-Base Regulator in Pacific Oyster Crassostrea gigas Exposed to Elevated CO2: Implication for Physiological Responses of Mollusk to Ocean Acidification
Journal
Marine Biotechnology
Wogonin reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12-CXCR4/7 axis in bone marrow microenvironment
Mitochondria-specific peptide amphiphiles induce mitochondrial dysfunction and peripheral T-cell lymphomas (PTCL) damage - PMC
Journal
Annals of translational medicine
MiR-495 regulates cellular ROS levels by targeting sod2 to inhibit intracellular survival of Mycobacterium tuberculosis in macrophages
Antibodies Specific to Membrane Proteins Are Effective in Complement-Mediated Killing of Mycoplasma bovis
Journal
Infection and Immunity
Species
Oryctolagus cuniculus
A membrane-bound dopamine β-hydroxylase highly expressed in granulocyte of Pacific oyster Crassostrea gigas
Journal
Developmental and Comparative Immunology
The hematopoiesis in gill and its role in the immune response of Pacific oyster Crassostrea gigas against secondary challenge with Vibrio splendidus
Journal
Developmental and comparative immunology
A hexokinase from the oyster Crassostrea gigas is involved in immune recognition as a pattern recognition receptor
The immune function of a novel crustin with an atypical WAP domain in regulating intestinal microbiota homeostasis in Litopenaeus vannamei
An insulin-like peptide serves as a regulator of glucose metabolism in the immune response of Chinese mitten crab Eriocheir sinensis
Journal
Developmental and Comparative Immunology
A novel cuticle protein involved in WSSV infection to the Pacific white shrimp Litopenaeus vannamei
Journal
Developmental and comparative immunology
Species
Litopenaeus vannamei
A C1qDC (CgC1qDC-6) with a collagen-like domain mediates hemocyte phagocytosis and migration in oysters.
Journal
Developmental and comparative immunology
A novel ubiquitin-protein ligase E3 functions as a modulator of immune response against lipopolysaccharide in Pacific oyster, Crassostrea gigas
Journal
Developmental And Comparative Immunology
Targeting PIK3CG in Combination with Paclitaxel as a Potential Therapeutic Regimen in Claudin-Low Breast Cancer
Journal
Cancer Management and Research
A glutamic acid decarboxylase (CgGAD) highly expressed in hemocytes of Pacific oyster Crassostrea gigas
Journal
Developmental and comparative immunology
The truncated MyD88s negatively regulates TLR2 signal on expression of IL17-1 in oyster Crassostrea gigas
Journal
Developmental and comparative immunology
Spindle‐E is essential for gametogenesis in the silkworm, Bombyx mori
Species
Bombyx mori Linnaeus
Identification and characterization of a tumor necrosis factor receptor like protein encoded by Cyprinid Herpesvirus 2
Journal
Developmental and comparative immunology
Species
Carassius auratus gibelio
A CgIFNLP receptor from Crassostrea gigas and its activation of the related genes in human JAK/STAT signaling pathway
Journal
Developmental and comparative immunology
Two short peptidoglycan recognition proteins from Crassostrea gigas with similar structure exhibited different PAMP binding activity
Journal
Developmental and comparative immunology
The construction of recombinant Lactobacillus casei expressing BVDV E2 protein and its immune response in mice
Journal
Journal of Biotechnology
Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells via inhibition of heat shock protein 27 phosphorylation - PMC
A method using angiotensin converting enzyme immobilized on magnetic beads for inhibitor screening
Journal
Journal of pharmaceutical and biomedical analysis
Emodin suppresses oxaliplatininduced neuropathic pain by inhibiting COX2/NFB mediated spinal inflammation
Journal
Journal of biochemical and molecular toxicology
microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis
THE IL-33/ST2 AXIS PROMOTES ACUTE RESPIRATORY DISTRESS SYNDROME BY NATURAL KILLER T CELLS - PMC
Journal
Shock (Augusta, Ga.)
Osteogenic microenvironment affects palatal development through glycolysis
Journal
Differentiation; research in biological diversity
Immunization with a recombinant fusion of porcine reproductive and respiratory syndrome virus modified GP5 and ferritin elicits enhanced protective immunity in pigs
Nuclear transporter karyopherin subunit alpha 3 levels modulate Porcine circovirus type 2 replication in PK-15 cells
Fusion of pseudorabies virus glycoproteins to IgG Fc enhances protective immunity against pseudorabies virus.
PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation
Journal
Acta Biochim Biophys Sin (Shanghai)
CPEB1, a novel risk gene in recent-onset schizophrenia, contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1
Journal
World J Psychiatry
A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions - PMC
Journal
Channels (Austin, Tex.)
Expression and Immunogenicity of Recombinant African Swine Fever Virus Proteins Using the Semliki Forest Virus
Journal
Frontiers in veterinary science
Species
Homo sapiens, Mus musculus
Sequence Analysis of Macaca mulatta TRIM4 and Its Role in the Interferon Pathway
Journal
Frontiers in veterinary science
Species
Chlorocebus aethiops
miR-657 Targets SRCIN1 via the Slug Pathway to Promote NSCLC Tumor Growth and EMT Induction - PMC
MicroRNA-1291 promotes endometrial fibrosis by regulating the ArhGAP29-RhoA/ROCK1 signaling pathway in a murine model
Journal
Molecular medicine reports
Species
Homo sapiens, Mus musculus
Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke
Journal
Molecular medicine reports
Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation
Journal
Molecular medicine reports
Effects of Txk‑mediated activation of NF‑κB signaling pathway on neurological deficit and oxidative stress after ischemia‑reperfusion in rats
Corilagin induces apoptosis and autophagy in NRF2‑addicted U251 glioma cell line
Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo.
Journal
Molecular Medicine Reports
A nuclear localization signal is required for the nuclear translocation of Fign and its microtubule‑severing function
Journal
Molecular medicine reports
Effect of SKF‑96365 on cardiomyocyte hypertrophy induced by angiotensin II
Journal
Molecular Medicine Reports
FAK regulates epithelial‑mesenchymal transition in adenomyosis.
Journal
Molecular medicine reports
Prognostic value of NOX2 as a potential biomarker for lung adenocarcinoma using TCGA and clinical validation - PMC
Journal
Molecular medicine reports
Role of TRIM22 in ulcerative colitis and its underlying mechanisms - PMC
Journal
Molecular medicine reports
MicroRNA-133b Inhibits nTumor Cell Proliferation, Migration and Invasion by Targeting SUMO1 in Endometrial Carcinoma
Journal
Technol Cancer Res Treat
B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo
Journal
Technol Cancer Res Treat
The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma
Journal
technol cancer res treat
Long Non-Coding RNA PVT1 Regulates the Resistance of the Breast Cancer Cell Line MDA-MB-231 to Doxorubicin via Nrf2
Journal
Technol Cancer Res Treat
Effects of chronic mild stress induced depression on synaptic plasticity in mouse hippocampus.
Journal
Behavioural brain research
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury
Journal
Behavioural Brain Research
Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy - PMC
Differential signaling signatures evoked by DOI versus lisuride stimulation of the 5-HT2A receptor
Journal
Biochemical and biophysical research communications
Species
Homo sapiens,Rattus norvegicus
Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway
Journal
Biochemical And Biophysical Research Communications
RGS16 regulates Hippo-YAP activity to promote esophageal cancer cell proliferation and migration
Journal
Biochemical and biophysical research communications
Knockdown of long non-coding RNA TINCR decreases radioresistance in colorectal cancer cells
Journal
Pathology, research and practice
ZIP12 Contributes to Hypoxic Pulmonary Hypertension by Driving Phenotypic Switching of Pulmonary Artery Smooth Muscle Cells
Journal
Journal of cardiovascular pharmacology
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas
Inhibiting MAPK14 showed anti-prolactinomas effect
Transmembrane p24 trafficking protein 2 regulates inflammation through the TLR4/NF-κB signaling pathway in lung adenocarcinoma
Journal
World journal of surgical oncology
Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma - PMC
Journal
World journal of surgical oncology
HSP90 inhibitors 17-AAG and VER-82576 inhibit porcine deltacoronavirus replication in vitro
A new strategy to develop pseudorabies virus-based bivalent vaccine with high immunogenicity of porcine circovirus type 2
O-acetyl-homoserine sulfhydrylase deficient Streptococcus suis serotype 2 strain SC19 becomes an avirulent strain and provides immune protection against
Journal
Veterinary microbiology
CD4 is an important Host Factor for Japanese Encephalitis Virus Entry and Replication in PK-15 Cells
Journal
Veterinary microbiology
Duck plague virus pUL15 performs a nonspecial cleavage activity through its C terminal nuclease domain in vitro
Journal
Veterinary microbiology
An Intracellular Epitope of ASFV CD2v Protein Elicits Humoral and Cellular Immune Responses - PMC
Journal
Animals : an open access journal from MDPI
Species
African swine fever virus
Microcyst fluid promotes the migration and invasion of fibroblasts in the adventitial layer of alveolar echinococcosis
TPI1 promotes MAPK/ERKinduced EMT, cell migration and invasion in lung adenocarcinoma
HBx-induced PLA2R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway - PMC
FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro
Microencapsulated Schwann Cell Transplantation Inhibits P2X2/3 Receptors Overexpression in a Sciatic Nerve Injury Rat Model with Neuropathic Pain
Journal
Neuroscience Letters
Identification of an LDLR variant in a Chinese familial hypercholesterolemia and its relation to ROS/NLRP3-Mediated pyroptosis in hepatic cells - PMC
Journal
Journal of geriatric cardiology : JGC
The opening of mitochondrial permeability transition pore (mPTP) and the inhibition of electron transfer chain (ETC) induce mitophagy in wheat roots under …
Elevated Secretion of Aldosterone Increases TG/HDL-C Ratio and Potentiates The Ox-LDL-Induced Dysfunction of HUVEC
COLEC12 regulates apoptosis of osteosarcoma through Toll‐like receptor 4–activated inflammation
Integrated bioinformatics analyses of key genes involved in hepatocellular carcinoma immunosuppression
MicroRNA-100 inhibits breast cancer cell proliferation, invasion and migration by targeting FOXA1
Long non-coding RNA MIR22HG inhibits glioma progression by downregulating microRNA-9/CPEB3
Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells
USF1 modulates transcription and cellular functions by regulating multiple transcription factors in Huh7 cells - PMC
GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK/NF-κB pathway in neuropathic pain mice
Journal
Neurobiol Learn Mem
Ozone-Mediated Cerebral Protection: Unraveling the Mechanism through Ferroptosis and the NRF2/SLC7A11/GPX4 Signaling Pathway
Journal
Journal of chemical neuroanatomy
Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing the transcription and splicing of tumorigenesis-related genes - PMC
RBM25 binds to and regulates alternative splicing levels of Slc38a9, Csf1, and Coro6 to affect immune and inflammatory processes in H9c2 cells - PMC
Flotillin-1 promotes EMT of gastric cancer via stabilizing Snail - PMC
Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6
Inhibitors of apoptosis proteins (IAPs) are associated with T-2 toxin-induced decreased collagen II in mouse chondrocytes in vitro
Chronic Electroacupuncture With High-Frequency at ST-36 Promotes Gastrointestinal Motility by Regulating Bone Morphogenetic Protein 2 Secretion of Muscularis
Journal
Neuromodulation : journal of the International Neuromodulation Society
Overexpression and RNAi-mediated Knockdown of Two 3β-hydroxy-Δ5-steroid dehydrogenase Genes in Digitalis lanata Shoot Cultures Reveal Their Role in …
The expression of Nramp1 modulates the uptake of Mycobacterium tuberculosis by macrophages through alternating inflammatory responses
Journal
Tuberculosis (Edinburgh, Scotland)
Tetramisole is a new IK1 channel agonist and exerts IK1-dependent cardioprotective effects in rats - PMC
Journal
Pharmacology research & perspectives
Autophagic and apoptotic proteins in goat corpus luteum and the effect of Adiponectin/AdipoRon on luteal cell autophagy and apoptosis
Dual role of NR4A1 in porcine ovarian granulosa cell differentiation and granulosa-lutein cell regression in vitro
Dietary curcumin supplementation relieves hydrogen peroxide-induced testicular injury by antioxidant and anti-apoptotic effects in roosters
Azeliragon ameliorates Alzheimer's disease via the Janus tyrosine kinase and signal transducer and activator of transcription signaling pathway
Journal
Clinics (Sao Paulo)
microRNA-26b inhibits growth and cellular invasion of ovarian cancer cells by targeting estrogen receptor α
FGF2 Functions in H2S's Attenuating Effect on Brain Injury Induced by Deep Hypothermic Circulatory Arrest in Rats
Journal
Molecular biotechnology
Efficient Humoral and Cellular Immune Responses Induced by a Chimeric Virus-like Particle Displaying the Epitope of EV71 without Adjuvant
Journal
Biomedical and environmental sciences
2-phenylacetamide Separated from the seed of Lepidium apetalum Willd. inhibited renal fibrosis via MAPK pathway mediated RAAS and oxidative stress in SHR Rats - PMC
Journal
BMC complementary medicine and therapies
Application
High Content Screening (HCS)
Development and application of an antibody detection ELISA for Haemophilus parasuis based on a monomeric autotransporter passenger domain
Journal
BMC Veterinary Research
SIRT3 inhibition suppresses hypoxia‐inducible factor 1α signaling and alleviates hypoxia‐induced apoptosis of type B spermatogonia GC‐2 cells
Identification of potential key genes and functional role of CENPF in osteosarcoma using bioinformatics and experimental analysis
Comparison of the differentiation abilities of bone marrow?derived mesenchymal stem cells and adipose?derived mesenchymal stem cells toward nucleus pulposus-like cells in three?dimensional culture
Inhibition of autophagy promotes human RSV NS1?induced inflammation and apoptosis in vitro
High glucose induces HSP47 expression and promotes the secretion of inflammatory factors through the IRE1α/XBP1/HIF?1α pathway in retinal Müller cells
MicroRNA?301a?3p promotes triple?negative breast cancer progression through downregulating MEOX2
Ozone induces tolerance against cardiomyocytes oxygen?glucose deprivation/reperfusion through inhibition of autophagy pathway
Long non-coding RNA ADAMTS9-AS2 inhibits liver cancer cell proliferation, migration and invasion
MicroRNA-122 inhibits epithelial-mesenchymal transition of hepatic stellate cells induced by the TGF-β1/Smad signaling pathway.
Journal
Experimental and Therapeutic Medicine
Ophiopogonin D attenuates PM2. 5‑induced inflammation via suppressing the AMPK/NF‑κB pathway in mouse pulmonary epithelial cells
Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice
PP2Ac knockdown attenuates lipotoxicity-induced pancreatic -cell dysfunction and apoptosis - PMC
Journal
Experimental and therapeutic medicine
Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice - PMC
Journal
Experimental and therapeutic medicine
Investigation of SRP9 protein expression in breast cancer
PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors.
Journal
Molecular biology reports
Hypothalamic NR3C1 DNA methylation in rats exposed to prenatal stress
Journal
Molecular biology reports
Methyltransferase-like (METTL) homologues participate in Nicotiana benthamiana antiviral responses - PMC
Journal
Plant signaling & behavior
A circular RNA from NFIX facilitates oxidative stress-induced H9c2 cells apoptosis
Journal
In Vitro Cell Dev Biol Anim
Effects of medical chitosan on capsular formation following silicone implant insertion in a rabbit model
Journal
Aesthetic plastic surgery
Species
Oryctolagus cuniculus
Isolation and genetic characteristics of a neurotropic teschovirus variant belonging to genotype 1 in northeast China
Journal
Archives of virology
Genomic characterization and pathogenicity of porcine deltacoronavirus strain CHN-HG-2017 from China.
Journal
Archives of virology
The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion - PMC
Journal
Journal of orthopaedic surgery and research
Effects of Changyu Daotan Decoction on Depression via Restoration of Mice Hippocampus and Alteration of Expression of Relevant Neurotrophic Factors - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
A trypsin inhibitor-like protein secreted by Cotesia vestalis teratocytes inhibits hemolymph prophenoloxidase activation of Plutella xylostella.
Journal
Journal of insect physiology
Species
Plutella xylostella
Effects of YAP1 and SFRP2 overexpression on the biological behavior of colorectal cancer cells and their molecular mechanisms
Journal
J Gastrointest Oncol
Nec-1 alleviated the deleterious effect of CoCl2 on C2C12 myoblast differentiation and fusion via the mTOR pathway
Three novel immunogenic proteins determined through 2-Dimensional electrophoresis and mass spectrometry with immune serum confer protection against challenge with porcine Pasteurella multocida in mouse models
Journal
Research in veterinary science
Naringenin ameliorates collagen-induced arthritis through activating AMPK-mediated autophagy in macrophages - PMC
Journal
Immunity, inflammation and disease
Quercetin-3-O-rutinoside from Moringa oleifera Downregulates Adipogenesis and Lipid Accumulation and Improves Glucose Uptake by Activation of AMPK/Glut-4 in 3T3-L1 Cells - PMC
Journal
Revista brasileira de farmacognosia : orgao oficial da Sociedade Brasileira de Farmacognosia
miR-181c, a potential mediator for acute kidney injury in a burn rat model with following sepsis
Journal
European journal of trauma and emergency surgery : official publication of the European Trauma Society
Activation of age-related NF-κB signaling pathway leads to chronic inflammation and pituitary fibrosis
Species
Homo sapiens,Rattus norvegicus
Death-Associated Protein Kinase 1 Regulates Oxidative Stress in Cardiac Ischemia Reperfusion Injury
Journal
Cells, tissues, organs
Development and Validation of Monoclonal Antibody-Based Antigen Capture ELISA for Detection of Group A Porcine Rotavirus
Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells
Endoplasmic reticulum stress mediates osteocyte death under oxygen-glucose deprivation in vitro
The in vitro antiviral activity of Lacticaseibacillus casei MCJ protein-based metabolites on bovine viral diarrhea virus
Development and evaluation of polyclonal antibodies based antigen capture ELISA for detection of porcine rotavirus
Journal
Animal biotechnology
The Mammalian Target of Rapamycin–70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma
Journal
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
Protective Effect of Salidroside on Mitochondrial Disturbances via Reducing Mitophagy and Preserving Mitochondrial Morphology in OGD-induced Neuronal Injury
Journal
Current medical science
Mitochondrial gene expression analysis reveals aberrant transcription of cox3 in Gossypium barbadense CMS line H276A
Journal
Development genes and evolution
Increased immunogenicity and protection of recombinant Sm14 antigens by heat-killed Cutibacterium acnes in BALB/c mice infected with Schistosoma mansoni
MicroRNA-219c-5p regulates bladder smooth muscle cell fibrosis by targeting FN1
Preliminary study on the function of TMEM50A and its correlation with the RH genes
Different fusion tags affect the activity of ubiquitin overexpression on spastin protein stability
Species
Chlorocebus aethiops
MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway - PMC
Journal
European journal of histochemistry : EJH
Porcine antibody profiles of 33 Mycoplasma hyopneumoniae fusion proteins from M. hyopneumoniae natural infection but not vaccination - PMC
Journal
Veterinary medicine and science
The Temporal and Spatial Changes of Th17, Tregs, and Related Cytokines in Epilepsy Lesions
Journal
Applied bionics and biomechanics
Selenium-enriched Polysaccharides from Pyracantha fortuneana (SePFP) Ameliorated Hepatic Lipid Accumulation through Enhancing Mitochondrial Fatty Acid
Journal
Journal of oleo science
Generation of a TRPV1 knockout human pluripotent stem cell line (WAe009-AU) via CRISPR/Cas9
Journal
Stem cell research
Effects of serum starvation and vascular endothelial growth factor stimulation on the expression of Notch signalling pathway components
miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2
Journal
Open life sciences
LACC1 contributes to inflammation and cognitive disorder after stroke via the AMPK/NLRP3 pathway
Journal
Acta neurobiologiae experimentalis
RNA 5-Methylcytosine regulators are associated with cell adhesion and predict prognosis of endometrial cancer - PMC
Journal
Translational cancer research
Hesperetin ameliorates glioblastoma by inhibiting proliferation, inducing apoptosis, and suppressing metastasis - PMC
Journal
Translational cancer research
The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1
Journal
The Journal of biological chemistry
The miR-17 92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation
Application
WB, ELISA, RT-PCR
Perilipin2 inhibits the replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions - PMC
Journal
World journal of virology
Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation
TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy
Journal
The Journal of biological chemistry
Species
Homo sapiens, Mus musculus
Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication - PMC
Species
Homo sapiens, Chlorocebus aethiops
NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer
Application
WB, CO-IP, RT-PCR
Species
Homo sapiens, Mus musculus
Expression of a Mycoparasite Protease in Plant Petals Suppresses the Petal-Mediated Infection by Necrotrophic Pathogens
Species
Coniothyrium minitans
Generation and Characterization of Monoclonal Antibodies against Swine Acute Diarrhea Syndrome Coronavirus Spike Protein - PMC
Species
Mus musculus, Homo sapiens
Persistent ER stress causes GPI anchor deficit to convert a GPI-anchored prion protein (PrP) into pro-PrP via the ATF6-miR449c-5p-PIGV axis
Journal
The Journal of biological chemistry
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-B signaling in keratinocyte - PMC
Journal
Cell death & disease
Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1 - PMC
Journal
RSC chemical biology
Species
Chlorocebus aethiops
Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1 Branch of the Endoplasmic Reticulum Stress Response - PMC
Journal
Stem cells international
Anti-Adipogenic and Anti-Obesity Effects of Gongmi Tea and Gongmi So Extract - PMC
Journal
Preventive nutrition and food science
Single-cell transcriptome reveals core cell populations and androgen-RXFP2 axis involved in deer antler full regeneration
Journal
Cell regeneration (London, England)
Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites
SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth - PMC
Journal
The Journal of biological chemistry
Resveratrol Synergistically Promotes BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells - PMC
Journal
Stem cells international
Lysine demethylase KDM1A promotes cell growth via FKBP8-BCL2 axis in hepatocellular carcinoma
Journal
The Journal of biological chemistry
Molecular cloning, expression and functional analysis of STAT2 in orange-spotted grouper, Epinephelus coioides
Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells