Brown-fat-mediated tumour suppression by cold-altered global metabolism - PMC
Mouse totipotent stem cells captured and maintained through spliceosomal repression
NIN-like protein transcription factors regulate leghemoglobin genes in legume nodules
SDX on the X chromosome is required for male sex determination
Cryo-EM structures of human organic anion transporting polypeptide OATP1B1
Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria
ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis - PMC
Journal
Signal transduction and targeted therapy
ALKBH3-dependent m 1 A demethylation of Aurora A mRNA inhibits ciliogenesis
Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta2C Modified with Chondroitin Sulfate (TACS)
Journal
Advanced materials (Deerfield Beach, Fla.)
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival
Journal
Cell host & microbe
Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling
Journal
American Journal of Respiratory and Critical Care Medicine
Young LINE-1 transposon 5 UTRs marked by elongation factor ELL3 function as enhancers to regulate nave pluripotency in embryonic stem cells
Journal
Nature cell biology
A viral movement protein targets host catalases for 26S proteasome-mediated degradation to facilitate viral infection and aphid transmission in wheat
Species
Oryctolagus cuniculus
Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis - PMC
Journal
Cellular & molecular immunology
Arabidopsis ECAP Is a New Adaptor Protein that Connects JAZ Repressors with the TPR2 Co-repressor to Suppress Jasmonate-Responsive Anthocyanin Accumulation
Species
Arabidopsis thaliana
Arabidopsis SYP121 acts as an ROP2 effector in the regulation of root hair tip growth
Species
Arabidopsis thaliana
A Phytophthora capsici RXLR effector targets and inhibits a plant PPIase to suppress endoplasmic reticulum-mediated immunity
Species
Phytophthora capsici
SADSCoV nsp1 inhibits the IFN production by preventing TBK1 phosphorylation and inducing CBP degradation
Journal
Journal of medical virology
Discovery of ligustrazine and chalcone derivatives as novel viral nucleoprotein nuclear export inhibitors against influenza viruses
Journal
Journal of medical virology
Engineering redirected NF-B/OIP5 expression programs to enhance tumor responses to chemotherapy in bladder cancer
PLK3 facilitates replication of swine influenza virus by phosphorylating viral NP protein
Journal
Emerging microbes & infections
Species
Homo sapiens,Sus scrofa
AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments - PMC
Journal
The Journal of clinical investigation
Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis
Journal
Brain, behavior, and immunity
Species
Homo sapiensMus musculus
A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Journal
Nature communications
Species
Homo sapiens, Mus musculus
Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models
Par complex cluster formation mediated by phase separation
Journal
Nature Communications
Species
Drosophila melanogaster
mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
Journal
Nature Communications
A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease
Journal
Nature Communications
Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
Journal
Nature Communications
The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division
Journal
Nature Communications
ATG14 targets lipid droplets and acts as an autophagic receptor for syntaxin18-regulated lipid droplet turnover - PMC
Journal
Nature communications
Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation - PMC
Journal
Nature communications
Species
Homo sapiens,Mus musculus
Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation - PMC
Journal
Nature communications
Species
Homo sapiens, Mus musculus
The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells - PMC
Journal
Nature communications
Pathogenesis-adaptive polydopamine nanosystem for sequential therapy of ischemic stroke - PMC
Journal
Nature communications
Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2 - PMC
Journal
Nature communications
Structural basis of the interaction between BCL9-Pygo and LDB-SSBP complexes in assembling the Wnt enhanceosome - PMC
Journal
Nature communications
Single-cell RNA-seq uncovers dynamic processes orchestrated by RNA-binding protein DDX43 in chromatin remodeling during spermiogenesis - PMC
Journal
Nature communications
Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes - PMC
Journal
Nature communications
Multiplex base editing to convert TAG into TAA codons in the human genome - PMC
Journal
Nature communications
Multi-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy - PMC
Journal
Nature communications
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway
Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Yin Yang 1Induced Long Noncoding RNA DUXAP9 Drives the Progression of Oral Squamous Cell Carcinoma by Blocking CDK1Mediated EZH2 Degradation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Genetic and Pharmacological Inhibition of Astrocytic Mysm1 Alleviates DepressiveLike Disorders by Promoting ATP Production
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Species
Homo sapiens, Mus musculus
SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Species
Homo sapiens, Mus musculus
Creation of Environmentally Friendly Super "Dinitrotoluene Scavenger" Plants
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ProteinNanocaged Selenium Induces t (8; 21) Leukemia Cell Differentiation via Epigenetic Regulation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Scar‐Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer - PMC
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 …
MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation - PMC
Journal
Nature communications
Blue light promotes vitamin C-mediated ferroptosis of melanoma through specifically upregulating transporter SVCT2 and generating Fe2+
NRF2 is a critical regulator and therapeutic target of metal implant particle-incurred bone damage
Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGasSting Axis in Spinal Cord Injury
A Biallelic Frameshift Mutation in Nephronectin Causes Bilateral Renal Agenesis in Humans
Journal
Journal of the American Society of Nephrology : JASN
Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders
Mitochondrial C1qbp promotes differentiation of effector CD8 + T cells via metabolic-epigenetic reprogramming
CD34+ cellderived fibroblast-macrophage cross-talk drives limb ischemia recovery through the OSM-ANGPTL signaling axis
Species
Homo sapiens, Mus musculus
Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus - PMC
Species
Oryctolagus cuniculus
Collagen hydrogel viscoelasticity regulates MSC chondrogenesis in a ROCK-dependent manner - PMC
Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors
Journal
Acta pharmaceutica Sinica. B
Species
Homo sapiens, Mus musculus
Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders
Uterine pyruvate metabolic disorder induced by silica nanoparticles act through the pentose phosphate pathway
Journal
Journal of hazardous materials
Daucosterol confers protection against T-2 toxin induced blood-brain barrier toxicity through the PGC-1-mediated defensive response in vitro and in vivo
Journal
Journal of hazardous materials
Coronaviral ORF6 protein mediates interorganelle contacts and modulates host cell lipid flux for virus production
Interleukin-1α leads to growth hormone deficiency in adamantinomatous craniopharyngioma by targeting pericytes: implication in pituitary fibrosis
Journal
Metabolism: clinical and experimental
Species
Homo sapiens,Rattus norvegicus
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics
Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer
ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation
Chemical conjugation of FITC to track silica nanoparticles in vivo and in vitro: An emerging method to assess the reproductive toxicity of industrial nanomaterials
A germline variant in the BET1L 3'-UTR confers colorectal cancer susceptibility by reducing miRNA binding and m6A modification
Megakaryocytes mediate hyperglycemia-induced tumor metastasis
Species
Homo sapiens, Mus musculus
Engineered Extracellular Vesicles to Enhance Antigen Presentation for Boosting Light-Driven Tumor Immunotherapy
The PGS1 basic helix-loop-helix protein regulates Fl3 to impact seed growth and grain yield in cereals
Journal
Plant biotechnology journal
Potato protein tyrosine phosphatase StPTP1a is activated by StMKK1 to negatively regulate plant immunity
Journal
Plant biotechnology journal
Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation
Journal
Molecular Therapy : the Journal of the American Society of Gene Therapy
Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation
Journal
Proceedings of the National Academy of Sciences of the United States of America
Original research: Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis - PMC
Journal
Journal for immunotherapy of cancer
Species
Homo sapiens, Mus musculus
Nitrogen-dependent binding of the transcription factor PBF1 contributes to the balance of protein and carbohydrate storage in maize endosperm
Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation
Journal
Cell death and differentiation
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer
Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1–Arih2 axis
Journal
Journal of cachexia, sarcopenia and muscle
Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis - PMC
Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition
BET inhibitor suppresses melanoma progression via the noncanonical NF-κB/SPP1 pathway
Nanotechnology-mediated immunochemotherapy with ingenol-3-mebutate for systematic anti-tumor effects
Journal
Journal of controlled release : official journal of the Controlled Release Society
Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections - PMC
Journal
Journal of controlled release : official journal of the Controlled Release Society
Species
Homo sapiens, Mus musculus
miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.
Species
Homo sapiens, Mus musculus
Decreased miR-214–3p activates NF-κB pathway and aggravates osteoarthritis progression.
BAP18 is involved in upregulation of CCND1/2 transcription to promote cell growth in oral squamous cell carcinoma
Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway - PMC
Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer.
Journal
Journal of experimental & clinical cancer research
LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification
Journal
J Exp Clin Cancer Res .
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer
Journal
J Exp Clin Cancer Res
Ca2+ signalling is critical for autoantibody‐induced blistering of human epidermis in pemphigus*
Journal
The British journal of dermatology
Development of a Novel DNA Aptamer Targeting Colorectal Cancer CellDerived Small Extracellular Vesicles as a Potential Diagnostic and Therapeutic Agent
Journal
Advanced healthcare materials
Rationally Designed, Self‐Assembling, Multifunctional Hydrogel Depot Repairs Severe Spinal Cord Injury
Journal
Advanced healthcare materials
The construction of three-dimensional composite fibrous macrostructures with nanotextures for biomedical applications
Distinctive Molecular and Metabolic Profiles of Chemically Synthesized Psilocybin and Psychedelic Mushroom Extract
Journal
Molecular psychiatry
Chronological attenuation of NPRA/PKG/AMPK signaling promotes vascular aging and elevates blood pressure
Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response - PMC
Species
Mus musculus;Homo sapiens
An LRH-RSL4 feedback regulatory loop controls the determinate growth of root hairs in Arabidopsis
Journal
Current biology : CB
Species
Arabidopsis thaliana
T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2
Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis
Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species - PMC
ROS-Drp1-mediated mitochondria fission contributes to hippocampal HT22 cell apoptosis induced by silver nanoparticles - PMC
Inhibiting SCD expression by IGF1R during lorlatinib therapy sensitizes melanoma to ferroptosis
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner - PMC
Ignored role of polyphenol in boosting reactive oxygen species generation for polyphenol/chemodynamic combination therapy - PMC
Journal
Materials today. Bio
In vitro and in vivo uterine metabolic disorders induced by silica nanoparticle through the AMPK signaling pathway
Real-ambient particulate matter exposure induced FGFR1 methylation contributes to cardiac dysfunction by altering cardiac lipid metabolism
Journal
The Science of the total environment
Species
Homo sapiens, Mus musculus
Resveratrol mitigates miR-212-3p mediated progression of diesel exhaust-induced pulmonary fibrosis by regulating SIRT1/FoxO3
Journal
The Science of the total environment
Effects of triclosan exposure on stem cells from human exfoliated deciduous teeth (SHED) fate
Journal
The Science of the total environment
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis - PMC
Journal
International journal of biological sciences
AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis - PMC
Journal
International journal of biological sciences
Ambient NO2 exposure induces migraine in rats: Evidence, mechanisms and interventions
Journal
The Science of the total environment
Transcriptional changes of Pacific oyster Crassostrea gigas reveal essential role of calcium signal pathway in response to CO2-driven acidification
Journal
The Science of the total environment
DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53
Journal
International journal of biological sciences
Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis.
Journal
International journal of biological sciences
Alginate oligosaccharide structures differentially affect DSS-induced colitis in mice by modulating gut microbiota
Journal
Carbohydrate polymers
Sulfate oligosaccharide of Gracilaria lemaneiformis modulates type 1 immunity by restraining T cell activation
Journal
Carbohydrate polymers
Co-administration of combretastatin A4 nanoparticles and sorafenib for systemic therapy of hepatocellular carcinoma
Journal
Acta biomaterialia
Mucoadhesive Carrier-Mediated Oral Co-delivery of Bcl2 Inhibitors Improves Gastric Cancer Treatment
Journal
ACS applied materials & interfaces
Species
Oryctolagus cuniculus
ROS Responsive Nanoparticles Encapsulated with Natural Medicine Remodel Autophagy Homeostasis in Breast Cancer
Journal
ACS applied materials & interfaces
DNA Supramolecular Hydrogel-Enabled Sustained Delivery of Metformin for Relieving Osteoarthritis
Journal
ACS applied materials & interfaces
Bioinspired Nanospheres as Anti-inflammation and Antisenescence Interfacial Biolubricant for Treating Temporomandibular Joint Osteoarthritis
Journal
ACS applied materials & interfaces
Mitochondrial Voltage-Dependent Anion Channel 1-Hexokinase-II Complex-Targeted Strategy for Melanoma Inhibition Using Designed Multiblock Peptide Amphiphiles
Journal
ACS applied materials & interfaces
Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation
Journal
Science China. Life Sciences
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy
Journal
Science China. Life sciences
A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells
Journal
Science China. Life sciences
Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis
Sex difference in adrenal developmental toxicity induced by dexamethasone and its intrauterine programming mechanism
Journal
Pharmacological research
Species
Rattus norvegicus, Homo sapiens
ENPP2 inhibitor improves proliferation in AOM/DSS-induced colorectal cancer mice via remodeling the gut barrier function and gut microbiota composition
Journal
Pharmacological research
Chip-DSF: A rapid screening strategy for drug protein targets
Journal
Pharmacological research
The blue light receptor CRY1 interacts with FIP37 to promote N6methyladenosine RNA modification and photomorphogenesis in Arabidopsis
Journal
The New phytologist
Species
Arabidopsis thaliana
SlERF. H6 mediates the orchestration of ethylene and gibberellin signaling that suppresses bitterSGA biosynthesis in tomato
Journal
The New phytologist
Phytophthora infestans RXLR effector PITG20303 targets a potato MKK1 protein to suppress plant immunity
Journal
The New phytologist
Species
Nicotiana benthamiana
A Meloidogyne incognita C‐type lectin effector targets plant catalases to promote parasitism
Journal
The New phytologist
Combined spinal-epidural anesthesia with acupoint injection for labor anesthesia reduces IL-1β/IL-10 ratio in maternal peripheral blood, umbilical cord blood and improves the labor outcomes: A prospective randomized controlled trial
Journal
Clinical immunology (Orlando, Fla.)
Placental trophoblast cells-derived exosomal microRNA-1290 promotes the interaction between endometrium and embryo by targeting LHX6
Journal
Mol Ther Nucleic Acids
Endometrial cell-derived small extracellular vesicle miR-100-5p promotes functions of trophoblast during embryo implantation
Journal
Mol Ther Nucleic Acids
Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis.
Journal
Mol Ther Nucleic Acids
DYSF promotes monocyte activation in atherosclerotic cardiovascular disease as a DNA methylation-driven gene
Journal
Translational research : the journal of laboratory and clinical medicine
Cardiac miR-19a/19b was induced and hijacked by CVB3 to facilitate virus replication via targeting viral genomic RdRp-encoding region
Journal
Antiviral research
In vitro and in vivo effects of 3-indoleacetonitrile—A potential new broad-spectrum therapeutic agent for SARS-CoV-2 infection - PMC
Journal
Antiviral research
The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer - PMC
Journal
NPJ precision oncology
DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
Coordination of tumor growth and host wasting by tumor-derived Upd3
Species
Drosophila melanogaster
CircRNA-IGLL1/miR-15a/RNF43 axis mediates ammonia-induced autophagy in broilers jejunum via Wnt/-catenin pathway
AMPK/PPAR-γ/NF-κB axis participates in ROS-mediated apoptosis and autophagy caused by cadmium in pig liver
Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN/PI3K/AKT in grass carp hepatocytes
Species
Ctenopharyngodon idellus
Comprehensive proteomic and phosphoproteomic reveal that Microcystin-LR contributed to the malignant progression of gastric cancer by estrogenic potency
Journal
Environmental pollution (Barking, Essex : 1987)
Smart dual responsive nanocarriers with reactive oxygen species amplification assisted synergistic chemotherapy against prostate cancer
Journal
Journal of colloid and interface science
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy - PMC
SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition
NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer
MORTALIN-Ca 2+ axis drives innate rituximab resistance in diffuse large B-cell lymphoma
Repression of let-7a cluster prevents adhesion of colorectal cancer cells by enforcing a mesenchymal phenotype in presence of liver inflammation
Journal
CELL DEATH & DISEASE
m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling
Journal
Cell death & disease
Hederagenin potentiated cisplatin-and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells
SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species
SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation.
FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation
FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation
MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4)
Journal
Cell Death & Disease
ERβ promotes Aβ degradation via the modulation of autophagy.
Journal
Cell Death & Disease
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma - PMC
Journal
Cell death & disease
Species
Homo sapiensMus musculus
The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission - PMC
MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC - PMC
FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis
GLV9 alleviates liver fibrosis via triggering GATA4mediated senescence in activated hepatic stellate cells
Journal
British journal of pharmacology
Cancer-associated dynamics and potential regulators of intronic polyadenylation revealed by IPAFinder using standard RNA-seq data
Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice
Journal
Journal Of Nanobiotechnology
Milk-derived Small Extracellular Vesicles: Nanomaterials to Promote Bone Formation
Journal
Journal of nanobiotechnology
Two-dimensional nanovermiculite and polycaprolactone electrospun fibers composite scaffolds promoting diabetic wound healing - PMC
Journal
Journal of nanobiotechnology
Effects of different electrostatic field intensities assisted controlled freezing point storage on water holding capacity of fresh meat during the early postmortem period
Validation of protein biological markers of lamb meat quality characteristics based on the different muscle types
Phosphorylation and acetylation of glycolytic enzymes cooperatively regulate their activity and lamb meat quality
NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment
Journal
Cellular and molecular life sciences
Species
Homo sapiens, Mus musculus
Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit α1 promote hydroxylation and secretion of type I collagen.
Journal
Cellular and molecular life sciences
Inhibition of KDM5A attenuates cisplatin-induced hearing loss via regulation of the MAPK/AKT pathway - PMC
Journal
Cellular and molecular life sciences : CMLS
Neuron derived fractalkine promotes microglia to absorb hematoma via CD163/HO-1 after intracerebral hemorrhage
Journal
Cellular and molecular life sciences : CMLS
Sertoli cell survival and barrier function are regulated by miR-181c/d-Pafah1b1 axis during mammalian spermatogenesis - PMC
Journal
Cellular and molecular life sciences : CMLS
Species
Mus musculus、Sus scrofa
Nitrogen-doped graphene quantum dots induce ferroptosis through disrupting calcium homeostasis in microglia
Journal
Particle and fibre toxicology
Safety assessment of graphene oxide and microcystin-LR complex: a toxicological scenario beyond physical mixture
Journal
Particle and fibre toxicology
Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch
Nucleotide-Binding Oligomerization Domain 1 (NOD1) Positively Regulates Neuroinflammation during Japanese Encephalitis Virus Infection
Journal
Microbiology spectrum
Porcine deltacoronavirus enters ST cells by clathrin-mediated endocytosis and does not require Rab5, Rab7, or Rab11 - PMC
Journal
Microbiology spectrum
Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis-Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK
Journal
Microbiology spectrum
TurboID Screening of the OmpP2 Protein Reveals Host Proteins Involved in Recognition and Phagocytosis of Glaesserella parasuis by iPAM Cells
Journal
Microbiology spectrum
Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus
Journal
Cell Chemical Biology
Enrofloxacin (ENR) exposure induces lipotoxicity by promoting mitochondrial fragmentation via dephosphorylation of DRP1 at S627 site
Glyphosate based-herbicide disrupts energy metabolism and activates inflammatory response through oxidative stress in mice liver
How UV radiation and pH alternation impact graphene oxide mediated environmental toxicant adsorption and resulting safety characteristics - A toxicology study beyond a classic carrier effect
Zinc attenuates sulfamethoxazole-induced lipotoxicity by reversing sulfamethoxazole-induced mitochondrial dysfunction and lysosome impairment in a freshwater teleost
Gradient Boosting Machine Learning Model for Defective Endometrial Receptivity Prediction by Macrophage-Endometrium Interaction Modules
Journal
Frontiers in immunology
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke
Journal
Frontiers in immunology
HSC70 Inhibits Spring Viremia of Carp Virus Replication by Inducing MARCH8-Mediated Lysosomal Degradation of G Protein
TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9
Human Cytomegalovirus miR-US33as-5p Targets IFNAR1 to Achieve Immune Evasion During Both Lytic and Latent Infection
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.
Journal
Frontiers in Immunology
The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats - PMC
Journal
Frontiers in immunology
Identification of cuproptosis hub genes contributing to the immune microenvironment in ulcerative colitis using bioinformatic analysis and experimental verification - PMC
Journal
Frontiers in immunology
CTSB promotes sepsis-induced acute kidney injury through activating mitochondrial apoptosis pathway - PMC
Journal
Frontiers in immunology
MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome - PMC
Journal
Frontiers in immunology
Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells - PMC
Journal
Frontiers in immunology
A metabolite attenuates neuroinflammation, synaptic loss and cognitive deficits induced by chronic infection of Toxoplasma gondii
- PMC
Journal
Frontiers in immunology
Integrated analysis of multiple microarray studies to establish differential diagnostic models of Crohns disease and ulcerative colitis based on a metalloproteinase-associated module - PMC
Journal
Frontiers in immunology
Response of immunoglobulin M in gut mucosal immunity of common carp (Cyprinus carpio) infected with Aeromonas hydrophila
- PMC
Journal
Frontiers in immunology
Diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization via miR-3061/Snail1 signaling - PMC
Journal
Frontiers in immunology
Mesenchymal Stem Cells Overexpressing ACE2 Favorably Ameliorate LPS-Induced Inflammatory Injury in Mammary Epithelial Cells.
Journal
Frontiers in immunology
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study
Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4-CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition
Journal
Cell Proliferation
Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination
Promotion of diced cartilage survival and regeneration with grafting of small intestinal submucosa loaded with urinederived stem cells
Journal
Cell proliferation
Species
Oryctolagus cuniculus
Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME - PMC
Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemia-reperfusion injury - PMC
Journal
Cellular & molecular biology letters
Identification of novel GPCR partners of the central melanocortin signaling
Characterization of viral insulins reveals white adipose tissue-specific effects in mice
A Viral Insulin-like Peptide Inhibits IGF-1 Receptor Phosphorylation and Regulates IGF1R Gene Expression
Journal
Molecular metabolism
Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma
Journal
Clinical and translational medicine
Species
Homo sapiens, Mus musculus
EEF2K silencing inhibits tumour progression through repressing SPP1 and synergises with BET inhibitors in melanoma
Journal
Clinical and translational medicine
The umbilical cord mesenchymal stem cell‐derived exosomal lncRNA H19 improves osteochondral activity through miR‐29b‐3p/FoxO3 axis
Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies - PMC
Journal
Clinical and translational medicine
SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion - PMC
Journal
Journal of translational medicine
Systematic analysis of various RNA transcripts and construction of biological regulatory networks at the post-transcriptional level for chronic obstructive pulmonary disease - PMC
Journal
Journal of translational medicine
Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease - PMC
Journal
Journal of translational medicine
Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress-mitophagy - PMC
Journal
Journal of translational medicine
MIR99AHG inhibits EMT in pulmonary fibrosis via the miR-136-5p/USP4/ACE2 axis - PMC
Journal
Journal of translational medicine
CircESRP1 enhances metastasis and epithelial-mesenchymal transition in endometrial cancer via the miR-874-3p/CPEB4 axis
Journal
Journal of translational medicine
CENPA promotes clear cell renal cell carcinoma progression and metastasis via Wnt/β-catenin signaling pathway
Reduction of miR-744 delivered by NSCLC cell-derived extracellular vesicles upregulates SUV39H1 to promote NSCLC progression via activation of the Smad9/BMP9 axis
Metabolomics-based molecular signatures reveal the toxic effect of co-exposure to nitrosamines in drinking water
Efficacy of a novel glioma therapy based on ferroptosis induced by layered double hydroxide loaded with simvastatin
Journal
Environmental research
A biopolymer-based and inflammation-responsive nanodrug for rheumatoid arthritis treatment via inhibiting JAK-STAT and JNK signalling pathways
Genome-wide identification, evolution of DNA methyltransferases and their expression under salinity stress in Larimichthys crocea
Journal
International journal of biological macromolecules
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment
Journal
Diabetes research and clinical practice
Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus
Journal
Free Radic Biol Med
Competition between two phosphatases fine-tunes Hedgehog signaling
Species
Drosophila melanogaster
BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats - PMC
Journal
Stem cell research & therapy
Species
Oryctolagus cuniculus
TNF-α/IL-1β-licensed hADSCs alleviate cholestatic liver injury and fibrosis in mice via COX-2/PGE2 pathway - PMC
Journal
Stem cell research & therapy
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer (CRPC).
Journal
Journal of medicinal chemistry
Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways
Journal
Journal of medicinal chemistry
Dual Nicotinamide Phosphoribosyltransferase (NAMPT) and Indoleamine 2, 3-Dioxygenase 1 (IDO1) Inhibitors for the Treatment of Drug-Resistant Nonsmall-Cell …
Journal
Journal of medicinal chemistry
MYST family histone acetyltransferases regulate reproductive diapause initiation
Journal
International journal of biological macromolecules
CRM197-conjugated multi antigen dominant epitope for effective human cytomegalovirus vaccine development
Journal
International journal of biological macromolecules
Species
Homo sapiens, Mus musculus
Engineering alginate/carboxymethylcellulose scaffolds to establish liver cancer spheroids: Evaluation of molecular variances between 2D and 3D models
Journal
International journal of biological macromolecules
Regulatory mechanism of miR-722 on C5aR1 and its functions against bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)
Journal
International journal of biological macromolecules
NPFR regulates the synthesis and metabolism of lipids and glycogen via AMPK: Novel targets for efficient corn borer management
Journal
International journal of biological macromolecules
Heterogalactan WPEP-Nb from Pleurotus eryngii enhances immunity in immunocompromised mice
Journal
International journal of biological macromolecules
Depletion of LOXL2 improves respiratory capacity: From air-breathing fish to mammal under hypoxia
Journal
International journal of biological macromolecules
A fluorescent probe for early detection of melanoma and its metastasis by specifically imaging tyrosinase activity in a mouse model
Journal
Analytical chemistry
CD36 as a Molecular Target of Functional DNA Aptamer NAFLD01 Selected against NAFLD Cells
Simultaneous Detection of a Cluster of Differentiation Markers on Leukemia-Derived Exosomes by Multiplex Immuno-Polymerase Chain Reaction via Capillary Electrophoresis Analysis
Susceptibility factor RTP1 negatively regulates Phytophthora parasitica resistance via modulating UPR regulators bZIP60 and bZIP28
The PPR-SMR Protein ATP4 Is Required for Editing the Chloroplast rps8 mRNA in Rice and Maize
A semi-dominant NLR allele causes whole-seedling necrosis in wheat
Species
Triticum aestivum L.
Surface Oxygen Deficiency Enabled Spontaneous Antiprotein Fouling in WO3 Nanosheets for Biosensing in Biological Fluids
Journal
Analytical chemistry
Protist ubiquitin ligase effector PbE3-2 targets cysteine protease RD21A to impede plant immunity
Cytidine-to-Uridine RNA Editing Factor NbMORF8 Negatively Regulates Plant Immunity to Phytophthora Pathogens
PGC-1-Coordinated Hypothalamic Antioxidant Defense Is Linked to SP1-LanCL1 Axis during High-Fat-Diet-Induced Obesity in Male Mice - PMC
Journal
Antioxidants (Basel, Switzerland)
Lycopene Maintains Mitochondrial Homeostasis to Counteract the Enterotoxicity of Deoxynivalenol - PMC
Journal
Antioxidants (Basel, Switzerland)
Species
Oryctolagus cuniculus
Selenomethionine Attenuated H2O2-Induced Oxidative Stress and Apoptosis by Nrf2 in Chicken Liver Cells - PMC
Journal
Antioxidants (Basel, Switzerland)
Oxidative Stress Induced by Selenium Deficiency Contributes to Inflammation, Apoptosis and Necroptosis in the Lungs of Calves - PMC
Journal
Antioxidants (Basel, Switzerland)
Extracellular Vesicles, as Drug-Delivery Vehicles, Improve the Biological Activities of Astaxanthin - PMC
Journal
Antioxidants (Basel, Switzerland)
Selenium Deficiency-Induced Oxidative Stress Causes Myocardial Injury in Calves by Activating Inflammation, Apoptosis, and Necroptosis - PMC
Journal
Antioxidants (Basel, Switzerland)
Bacterial Metabolite Reuterin Attenuated LPS-Induced Oxidative Stress and Inflammation Response in HD11 Macrophages - PMC
Journal
Antioxidants (Basel, Switzerland)
miR-135a Suppresses Granulosa Cell Growth by Targeting Tgfbr1 and Ccnd2 during Folliculogenesis in Mice
Parkin-Dependent Mitophagy Is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
MicroRNAs in Small Extracellular Vesicles Indicate Successful Embryo Implantation during Early Pregnancy
Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells
APN Expression in Serum and Corpus Luteum: Regulation of Luteal Steroidogenesis Is Possibly Dependent on the AdipoR2/AMPK Pathway in Goats
Diallyl Trisulfide Causes Male Infertility with Oligoasthenoteratospermia in Sitotroga cerealella through the Ubiquitin-Proteasome Pathway - PMC
A Rapid Alkalinization Factor-like Peptide EaF82 Impairs Tapetum Degeneration during Pollen Development through Induced ATP Deficiency - PMC
Species
Arabidopsis thaliana
ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA - PMC
The Efficacy of HGF/VEGF Gene Therapy for Limb Ischemia in Mice with Impaired Glucose Tolerance: Shift from Angiogenesis to Axonal Growth and Oxidative Potential in Skeletal Muscle - PMC
Transcriptome Analysis Unveils That Exosomes Derived from M1-Polarized Microglia Induce Ferroptosis of Neuronal Cells - PMC
Synergism of Feeding and Digestion Regulated by the Neuropeptide F System in Ostrinia furnacalis Larvae - PMC
Species
Ostrinia furnacalis
Host HSPD1 Translocation from Mitochondria to the Cytoplasm Induced by Streptococcus suis Serovar 2 Enolase Mediates Apoptosis and Loss of Blood-Brain Barrier Integrity - PMC
A dynamic matrix potentiates mesenchymal stromal cell paracrine function via an effective mechanical dose
Journal
Biomaterials science
A polymeric nanoformulation improves the bioavailability and efficacy of sorafenib for hepatocellular carcinoma therapy
Journal
Biomaterials science
Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome
Journal
Cell communication and signaling : CCS
1-Pyrroline-5-carboxylate inhibit T cell glycolysis in prostate cancer microenvironment by SHP1/PKM2/LDHB axis - PMC
Journal
Cell communication and signaling : CCS
GETV nsP2 plays a critical role in the interferon antagonism and viral pathogenesis - PMC
Journal
Cell communication and signaling : CCS
Species
Homo sapiens, Mus musculus
Modulation of apoptosis and Inflammasome activation in chondrocytes: co-regulatory role of Chlorogenic acid - PMC
Journal
Cell communication and signaling : CCS
Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ER axis - PMC
Journal
Cell communication and signaling : CCS
GPR65 inhibits human trophoblast cell adhesion through upregulation of MYLK and downregulation of fibronectin via cAMP-ERK signaling in a low pH environment - PMC
Journal
Cell communication and signaling : CCS
Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis - PMC
Journal
Cell communication and signaling : CCS
LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure - PMC
Journal
Cell communication and signaling : CCS
Slc2a6 regulates myoblast differentiation by targeting LDHB - PMC
Journal
Cell communication and signaling : CCS
Species
Oryctolagus cuniculus
Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication
Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication
The PRMT5/WDR77 complex restricts hepatitis E virus replication
Aspergillus fumigatus Elongator complex subunit 3 affects hyphal growth, adhesion and virulence through wobble uridine tRNA modification - PMC
ADAM17: A novel treatment target for aneurysms
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Transcription factor 7-like 2 controls matrix degradation through nuclear factor B signaling and is repressed by microRNA-155 in nucleus pulposus cells
Journal
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
Species
Homo sapiens, Rattus norvegicus
Purendan alleviates non-alcoholic fatty liver disease in aged type 2 diabetic rats via regulating mTOR/S6K1/SREBP-1c signaling pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Anticancer activity of methylene blue via inhibition of heat shock protein 70
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Protective effects of dioscin against cartilage destruction in a monosodium iodoacetate (MIA)-indcued osteoarthritis rat model
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Potentilla discolor ameliorates LPS-induced inflammatory responses through suppressing NF-κB and AP-1 pathways
Journal
Biomed Pharmacother
GJ-4 alleviates Aβ25-35-induced memory dysfunction in mice through protecting the neurovascular unit
Journal
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
AICAR prolongs corneal allograft survival via the AMPK-mTOR signaling pathway in mice.
Journal
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
Activation of 7nAChR preserves intestinal barrier integrity by enhancing the HO-1/STAT3 signaling to inhibit NF-B activation in mice
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Species
Homo sapiens, Mus musculus
Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Ozone pretreatment alleviates ischemiareperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Cordycepin inhibits myogenesis via activating the ERK1/2 MAPK signalling pathway in C2C12 cells
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
NHWD-1062 ameliorates inflammation and proliferation by the RIPK1/NF-κB/TLR1 axis in Psoriatic Keratinocytes
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Microalga Chlorella sp. extract induced apoptotic cell death of cholangiocarcinoma via AKT/mTOR signaling pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dioscin potentiates the antitumor effect of suicide gene therapy in melanoma by gap junction intercellular communication-mediated antigen cross-presentation
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Species
Chlorocebus sabaeus
Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma - PMC
Journal
Journal of translational medicine
The chromosome-level genome and key genes associated with mud-dwelling behavior and adaptations of hypoxia and noxious environments in loach (Misgurnus anguillicaudatus) - PMC
Species
Misgurnus anguillicaudatus
Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD - PMC
Journal
Oxidative medicine and cellular longevity
P-Glycoprotein Exacerbates Brain Injury Following Experimental Cerebral Ischemia by Promoting Proinflammatory Microglia Activation - PMC
Journal
Oxidative medicine and cellular longevity
Traxoprodil Produces Antidepressant-Like Behaviors in Chronic Unpredictable Mild Stress Mice through BDNF/ERK/CREB and AKT/FOXO/Bim Signaling Pathway - PMC
Journal
Oxidative medicine and cellular longevity
Enriched Environment Attenuates Ferroptosis after Cerebral Ischemia/Reperfusion Injury via the HIF-1α-ACSL4 Pathway - PMC
Journal
Oxidative medicine and cellular longevity
Ferroptosis in Rat Lung Tissue during Severe Acute Pancreatitis-Associated Acute Lung Injury: Protection of Qingyi Decoction - PMC
Journal
Oxidative medicine and cellular longevity
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier - PMC
Journal
Oxidative medicine and cellular longevity
Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway - PMC
Journal
Oxidative medicine and cellular longevity
Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy - PMC
Journal
Oxidative medicine and cellular longevity
Heat Shock Protein 22 Attenuates Nerve Injury-induced Neuropathic Pain Via Improving Mitochondrial Biogenesis and Reducing Oxidative Stress Mediated By Spinal
Journal
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Down-regulation of MBD4 contributes to hypomethylation and overexpression of CD70 in CD4+ T cells in systemic lupus erythematosus.
Journal
Clinical Epigenetics
NK92 cells and peripheral blood NK cells respond oppositely upon dasatinib treatment
New role of gramicidin A in RIG‐I‐like receptors‐mediated IFN signaling
HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson's disease models
Journal
Acta Pharmacol Sin
Species
Homo sapiens, Mus musculus
Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage
Journal
Acta pharmacologica Sinica
DUBR suppresses migration and invasion of human lung adenocarcinoma cells via ZBTB11-mediated inhibition of oxidative phosphorylation
Journal
Acta Pharmacol Sin
Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer.
Journal
Acta pharmacologica Sinica
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway
Journal
Acta pharmacologica Sinica
Effect of total flavonoids of Rhizoma Drynariae in thiram induced cytotoxicity of chondrocyte via BMP-2/Runx2 and IHH/PTHrP expressions
Journal
Ecotoxicology and environmental safety
Cluster of differentiation 147 (CD147) expression is linked with thiram induced chondrocyte's apoptosis via Bcl-2/Bax/Caspase-3 signalling in tibial growth plate under chlorogenic acid repercussion
Journal
Ecotoxicol Environ Saf
Role of Clusterin/NF-κB in the secretion of senescence-associated secretory phenotype in Cr (VI)-induced premature senescent L-02 hepatocytes
Journal
Ecotoxicology and environmental safety
Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/GSK-3β pathways in broilers
Journal
Ecotoxicol Environ Saf
Regulation of apoptosis by Pacific oyster Crassostrea gigas reveals acclimation strategy to CO 2 driven acidification
Journal
Ecotoxicol Environ Saf
Aluminum-maltol induced oxidative stress and reduced AMPK activity via BCK-related energy supply failure in C6 cell
Journal
Ecotoxicology and environmental safety
Tanshinone IIA protects intestinal epithelial cells from deoxynivalenol-induced pyroptosis
Journal
Ecotoxicology and environmental safety
Lactational exposure to Deoxynivalenol causes mammary gland injury via inducing inflammatory response and impairing blood-milk barrier integrity in mice
Journal
Ecotoxicology and environmental safety
Paneth cells protect intestinal stem cell niche to alleviate deoxynivalenol-induced intestinal injury
Journal
Ecotoxicology and environmental safety
Transgenerational inheritance of wing development defects in Drosophila melanogaster induced by cadmium
Journal
Ecotoxicology and environmental safety
Targeting the lncMST-EPRS/HSP90AB1 complex as novel therapeutic strategy for T-2 toxin-induced growth retardation
Journal
Ecotoxicology and environmental safety
Acute nitrite exposure interferes with intestinal thyroid hormone homeostasis in grass carp (Ctenopharyngodon idellus)
Journal
Ecotoxicology and environmental safety
Species
Ctenopharyngodon idellus
Metformin antagonizes nickel-refining fumes-induced cell pyroptosis via Nrf2/GOLPH3 pathway in vitro and in vivo
Journal
Ecotoxicology and environmental safety
Metformin alleviates nickel-refining fumes-induced aerobic glycolysis via AMPK/GOLPH3 pathway in vitro and in vivo
Journal
Ecotoxicology and environmental safety
Ozone causes depressive-like response through PI3K/Akt/GSK3β pathway modulating synaptic plasticity in young rats
Journal
Ecotoxicology and environmental safety
Metabolomic transition trajectory and potential mechanisms of N-nitrosomethylbenzylamine induced esophageal squamous cell carcinoma in rats
Journal
Ecotoxicology and environmental safety
Persistent ferroptosis promotes cervical squamous intraepithelial lesion development and oncogenesis by regulating KRAS expression in patients with high risk-HPV infection
Journal
Cell death discovery
Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway - PMC
Journal
Cell death discovery
Design, synthesis and evaluation of novel UDCA-aminopyrimidine hybrids as ATX inhibitors for the treatment of hepatic and pulmonary fibrosis
Journal
European journal of medicinal chemistry
Discovery of novel nitrogenous heterocyclic-containing quinoxaline-1, 4-di-N-oxides as potent activator of autophagy in M. tb-infected macrophages
Journal
European journal of medicinal chemistry
Development of novel celastrol-ligustrazine hybrids as potent peroxiredoxin 1 inhibitors against lung cancer
Journal
European journal of medicinal chemistry
Pyrido [2, 3-d] pyrimidine-2, 4 (1H, 3H)-dione derivatives as RAF-MEK-ERK pathway signaling pathway blockers: Synthesis, cytotoxic activity, mechanistic …
Journal
European journal of medicinal chemistry
Effects of various levels of dietary fiber on carcass traits, meat quality and myosin heavy chain I, IIa, IIx and IIb expression in muscles in Erhualian and Large White pigs
Resveratrol improves meat quality traits by activating the lncRNAs-KEAP1-NRF2 axis in pigs
Integrating identification and targeted proteomics to discover the potential indicators of postmortem lamb meat quality
miR-145a-5p/Plexin-A2 promotes the migration of OECs and transplantation of miR-145a-5p engineered OECs promotes the functional recovery in rats with …
Journal
Neurobiology of disease
Hollow Hydroxyapatite Microspheres Loaded with rhCXCL13 to Recruit BMSC for Osteogenesis and Synergetic Angiogenesis to Promote Bone Regeneration in Bone Defects - PMC
Journal
International journal of nanomedicine
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO1 pathway
Journal
CNS neuroscience & therapeutics
Down-Regulation of HSP by Pd-Cu Nanozymes for NIR Light Triggered Mild-Temperature Photothermal Therapy Against Wound Bacterial Infection: In vitro and in vivo Assessments - PMC
Journal
International journal of nanomedicine
Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA - PMC
Journal
International journal of nanomedicine
LIPUS‐SCs‐Exo promotes peripheral nerve regeneration in cavernous nerve crush injury‐induced ED rats via PI3K/Akt/FoxO signaling pathway
Journal
CNS neuroscience & therapeutics
Selenium Nanoparticles-Enriched Lactobacillus casei ATCC 393 Prevents Cognitive Dysfunction in Mice Through Modulating Microbiota-Gut-Brain Axis - PMC
Journal
International journal of nanomedicine
Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner - PMC
Journal
Cell death discovery
Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner - PMC
Journal
Cell death discovery
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway
Journal
Cell Death Discovery
Species
Homo sapiens, Mus musculus
Osteoarthritic infrapatellar fat pad aggravates cartilage degradation via activation of p38MAPK and ERK1/2 pathways
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Deletion of the first glycosylation site promotes Lassa virus glycoprotein-mediated membrane fusion
Species
Homo sapiens, Chlorocebus aethiops
miR-129-5p targets FEZ1/SCOC/ULK1/NBR1 complex to restore neuronal function in mice with post-stroke depression
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma
N 6 -methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m 6 A/FOXM1 axis
Investigation on the expression regulation of RIPK1/RIPK3 in the retinal ganglion cells (RGCs) cultured in high glucose
Regulating COX10-AS1/miR-142-5p/PAICS axis inhibits the proliferation of non-small cell lung cancer
Mechanisms of Dendrobium officinale polysaccharides in repairing gastric mucosal injuries based on mitogen-activated protein kinases (MAPK) signaling pathway
MicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjögren's syndrome
Alpha-2 Heremans Schmid Glycoprotein (AHSG) promotes the proliferation of bladder cancer cells by regulating the TGF-β signalling pathway - PMC
Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis
Journal
Cell biology and toxicology
Exosomal miR-218 derived from mesenchymal stem cells inhibits endothelial-to-mesenchymal transition by epigenetically modulating of BMP2 in pulmonary fibrosis
Journal
Cell biology and toxicology
Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondrial Fission
Journal
Translational Stroke Research
POSH participates in epileptogenesis by increasing the surface expression of the NMDA receptor: a promising therapeutic target for epilepsy
Journal
Expert Opinion on Therapeutic Targets
N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury
Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells.
Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and lipotoxicity
Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3
Anti-inflammatory role and mechanism of microRNA-92b-3p in the progression of hypoxic pulmonary hypertension
Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells
Probiotic Enterococcus faecalis AG5 mitigated high fat diet induced obesity and produced propionic acid stimulated apoptosis in 3T3-L1 pre-adipocyte
High-fat diet increased NADPH-oxidase-related oxidative stress and aggravated LPS-induced intestine injury
Osthole attenuates APP-induced Alzheimer's disease through up-regulating miRNA-101a-3p.
MicroRNA-145 overexpression attenuates apoptosis and increases matrix synthesis in nucleus pulposus cells.
Astragaloside IV inhibits Angiotensin II-stimulated proliferation of rat vascular smooth muscle cells via the regulation of CDK2 activity
p55PIK regulates alpha-fetoprotein expression through the NF-κB signaling pathway
The Anti-Inflammatory Effect of Bovine Bone-Gelatin-Derived Peptides in LPS-Induced RAW264.7 Macrophages Cells and Dextran Sulfate Sodium-Induced C57BL/6 Mice
Sesamol Alleviates Obesity-Related Hepatic Steatosis via Activating Hepatic PKA Pathway
Piceatannol Protects PC-12 Cells against Oxidative Damage and Mitochondrial Dysfunction by Inhibiting Autophagy via SIRT3 Pathway - PMC
Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in …
Stingless Bee (Heterotrigona Itama) Honey and Its Phenolic-Rich Extract Ameliorate Oxidant-Antioxidant Balance via KEAP1-NRF2 Signalling Pathway - PMC
The metabolite saccharopine impairs neuronal development by inhibiting the neurotrophic function of glucose-6-phosphate isomerase
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
A distinct metabolically defined central nucleus circuit bidirectionally controls anxiety-related behaviors
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
S. boulardii Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats - PMC
Mechanism of Astragalus membranaceus Alleviating Acquired Hyperlipidemia Induced by High-Fat Diet through Regulating Lipid Metabolism
Amelioration of hyperglycaemia and hyperlipidaemia by adjusting the interplay between gut microbiota and bile acid metabolism: Radix Scutellariae as a case
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Chlorogenic acid suppresses mitochondrial apoptotic effectors Bax/Bak to counteract Nod-like receptor pyrin domain 3 (NLRP3) inflammasome in thiram exposed chondrocytes
nNovel insights into antidepressant mechanism of Kai Xin San formula: inhibiting NLRP3 inflammasome activation by promoting autophagy
Trigonelline induces autophagy to protect mesangial cells in response to high glucose via activating the miR-5189-5p-AMPK pathway
Gardenia jasminoides J. Ellis extract GJ-4 alleviated cognitive deficits of APP/PS1 transgenic mice
Purslane (Portulacae oleracea L.) attenuates cadmium-induced hepatorenal and colonic damage in mice: Role of chelation, antioxidant and intestinal microecological regulation
Zuogui Pill Disrupt the Malignant Cycle in Breast Cancer Bone Metastasis through the Piezo1-Notch-1-GPX4 Pathway and Active Molecules Fishing
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Astragaloside IV Attenuates Hypoxia-Induced Cardiac Hypertrophy Via Calpain-1-Mediated Mtor Activation
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Species
Mus musculus,Rattus norvegicus
San Huang Xiao Yan recipe modulates the HMGB1-mediated abnormal inflammatory microenvironment and ameliorates diabetic foot by activating the AMPK/Nrf2
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
San Huang Xiao Yan recipe modulates the HMGB1-mediated abnormal inflammatory microenvironment and ameliorates diabetic foot by activating the AMPK/Nrf2
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Piperine alleviates acute pancreatitis: A possible role for FAM134B and CCPG1 dependent ER-phagy
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1β reduction in thiram exposed chondrocytes via caspase-3/caspase-7 pathway
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway
Journal
Biochim Biophys Acta Mol Basis Dis
Autotaxin (ATX) inhibits autophagy leading to exaggerated disruption of intestinal epithelial barrier in colitis
Journal
Biochimica et biophysica acta. Molecular basis of disease
Species
Homo sapiens, Mus musculus
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis
Journal
Biochimica et biophysica acta. Molecular basis of disease
A prospective diagnostic and prognostic biomarker for hepatocellular carcinoma that functions in glucose metabolism regulation: Solute carrier family 37 member 3
Journal
Biochimica et biophysica acta. Molecular basis of disease
The Small Secreted Protein FoSsp1 Elicits Plant Defenses and Negatively Regulates Pathogenesis in Fusarium oxysporum f. sp. cubense (Foc4)
Journal
Frontiers in plant science
Localization, Gene Expression, and Functions of Glutamine Synthetase Isozymes in Wheat Grain ( Triticum aestivum L.)
Development of Novel Glyphosate-Tolerant Japonica Rice Lines: A Step Toward Commercial Release
Journal
Frontiers In Plant Science
Transcriptomic and functional analyses reveal the molecular mechanisms underlying Fe-mediated tobacco resistance to potato virus Y infection - PMC
Journal
Frontiers in plant science
Histone acetylation functions in the wound-induced spore formation in nori - PMC
Journal
Frontiers in plant science
Intestinal Flora Dysbiosis Aggravates Cognitive Dysfunction Associated With Neuroinflammation in Heart Failure
Journal
Journal of Cardiac Failure
Active fractions of golden-flowered tea (Camellia nitidissima Chi) inhibit epidermal growth factor receptor mutated non-small cell lung cancer via multiple pathways and targets in vitro and in vivo - PMC
Journal
Frontiers in nutrition
Species
Homo sapiens, Mus musculus
Luteolin regulates the distribution and function of organelles by controlling SIRT1 activity during postovulatory oocyte aging - PMC
Journal
Frontiers in nutrition
Attenuator LRR - a regulatory tool for modulating gene expression in Gram-positive bacteria
An innovative protein expression system using RNA polymerase I for large-scale screening of high-nucleic-acid content Saccharomyces cerevisiae strains
Species
Saccharomyces cerevisiae
Oxidative Stress Mediated by N6Methyladenosine Methylation Contributes to HighFat Diet Induced Male Reproductive Dysfunction
Journal
Molecular nutrition & food research
Pretreatment with Kahweol Attenuates SepsisInduced Acute Lung Injury via Improving Mitochondrial Homeostasis in a CaMKKII/AMPKDependent Pathway
Journal
Molecular nutrition & food research
Revealing Pan-Histology Immunomodulatory Targets in Pediatric Central Nervous System Tumors - PMC
Farnesol exerts protective effects against chronic sleep deprivation‐induced cognitive impairment via activation SIRT1/Nrf2 pathway in the hippocampi of adult mice
Journal
Molecular nutrition & food research
Sodium New Houttuyfonate Induces Apoptosis of Breast Cancer Cells via ROS/PDK1/AKT/GSK3β Axis - PMC
Using Patient-Derived Xenograft (PDX) Models as a ‘Black Box to Identify More Applicable Patients for ADP-Ribose Polymerase Inhibitor (PARPi) Treatment in Ovarian Cancer: Searching for Novel Molecular and Clinical Biomarkers and Performing a Prospec
HSF1 Attenuates LPS-Induced Acute Lung Injury in Mice by Suppressing Macrophage Infiltration
Journal
Oxid Med Cell Longev
Circular RNA circPHKA2 Relieves OGD-Induced Human Brain Microvascular Endothelial Cell Injuries through Competitively Binding miR-574-5p to Modulate SOD2
Journal
Oxid Med Cell Longev
Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGFβR Regulating TGF-β/Smad Pathway
Journal
Oxid Med Cell Longev
Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway
Journal
Oxid Med Cell Longev
Exosomal MATN3 of Urine-Derived Stem Cells Ameliorates Intervertebral Disc Degeneration by Antisenescence Effects and Promotes NPC Proliferation and ECM Synthesis byActivating TGF-β
Journal
Oxid Med Cell Longev
Exosomes Derived from Human Urine-Derived Stem Cells Inhibit Intervertebral Disc Degeneration by Ameliorating Endoplasmic Reticulum Stress
Journal
Oxid Med Cell Longev
The Inhibition of miR-873 Provides Therapeutic Benefit in a Lipopolysaccharide-Induced Neuroinflammatory Model of Parkinson's Disease
Journal
Oxid Med Cell Longev
FTO-mediated m6A demethylation regulates GnRH expression in the hypothalamus via the PLC3/Ca2+/CAMK signalling pathway - PMC
Journal
Communications biology
p38MAPK-and GSK3-Mediated Phosphorylation of Snakehead Vesiculovirus Phosphoprotein at Threonine 160 Facilitates Viral Replication
Journal
Journal of virology
Prohibitin1 facilitates viral replication by impairing the RIG-I-like receptor signaling pathway
Journal
Journal of virology
Nanopore long-read RNA sequencing reveals functional alternative splicing variants in human vascular smooth muscle cells - PMC
Journal
Communications biology
Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis - PMC
Journal
Communications biology
HDAC6 Degrades nsp8 of Porcine Deltacoronavirus through Deacetylation and Ubiquitination to Inhibit Viral Replication
Journal
Journal of virology
The Host Protein CAD Regulates the Replication of FMDV through the Function of Pyrimidines De Novo Synthesis - PMC
Journal
Journal of virology
Species
Mesocricetus auratus
DDX3X Is Hijacked by Snakehead Vesiculovirus Phosphoprotein To Facilitate Virus Replication via Stabilization of the Phosphoprotein
Journal
Journal of virology
Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants - PMC
Journal
Communications biology
Tembusu Virus Nonstructural Protein 2B Antagonizes Type I Interferon Production by Targeting MAVS for Degradation
Journal
Journal of virology
Establishment of Full-Length cDNA Clones and an Efficient Oral Infection Model for Feline Coronavirus in Cats
Journal
Journal of virology
Regulation of Cr(VI)-Induced Premature Senescence in L02 Hepatocytes by ROS-Ca 2+ -NF- κ B Signaling
Journal
Oxidative medicine and cellular longevity
Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis
Journal
Oxid Med Cell Longev
The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death
Pharmaceutical Approach to Develop Novel Photosensitizer Nanoformulation: An Example of Design and Characterization Rationale of Chlorophyll Derivative - PMC
Mechanism of TCF21 Downregulation Leading to Immunosuppression of Tumor-Associated Macrophages in Non-Small Cell Lung Cancer - PMC
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release - PMC
Ultrasonic Microbubble Cavitation Deliver Gal-3 shRNA to Inhibit Myocardial Fibrosis after Myocardial Infarction - PMC
Pharmacological modulation of dual melanocortin4 receptor signaling by melanocortin receptor accessory proteins in the Xenopus laevis
Journal
Journal of cellular physiology
Long noncoding RNA TCL6 binds to miR‐106a‐5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway
Journal
Journal of cellular physiology
Trimethylamine N‐oxide exacerbates acetaminophen‐induced liver injury by interfering with macrophage‐mediated liver regeneration
RUNX2 co-operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers
Journal
Journal of Cellular Physiology
Cadherin5 facilitated the differentiation of human induced pluripotent stem cells into sinoatrial nodelike pacemaker cells by regulating catenin
Journal
Journal of cellular physiology
miR‐136‐5p/FZD4 axis is critical for Wnt signaling‐mediated myogenesis and skeletal muscle regeneration
Journal
Journal of cellular physiology
Transferrin-conjugated liposomes loaded with carnosic acid inhibit liver cancer growth by inducing mitochondria-mediated apoptosis
Journal
International journal of pharmaceutics
NADH dehydrogenase-like complex L subunit improves salt tolerance by enhancing photosynthetic electron transport
Journal
Plant physiology and biochemistry : PPB
Effects of phosphoglycerate kinase 1 and pyruvate kinase M2 on metabolism and physiochemical changes in postmortem muscle - PMC
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure-induced cardiotoxicity in swine
Journal
BioFactors (Oxford, England)
CDCA7‐regulated inflammatory mechanism through TLR4/NF‐κB signaling pathway in stomach adenocarcinoma
Journal
BioFactors (Oxford, England)
miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy
Journal
Cancer cell international
Lactate Induces Aberration in the miR-30a-DBF4 Axis to Promote the Development of Gastric Cancer and Weakens the Sensitivity to 5-Fu
Clinical significance and immune infiltration analyses of a novel coagulation-related signature in ovarian cancer - PMC
Journal
Cancer cell international
Gastric cancer cell-originated small extracellular vesicle induces metabolic reprogramming of BM-MSCs through ERK-PPARγ-CPT1A signaling to potentiate lymphatic metastasis - PMC
Journal
Cancer cell international
Identification and validation of an E2F-related gene signature for predicting recurrence-free survival in human prostate cancer - PMC
Journal
Cancer cell international
As a prognostic biomarker of clear cell renal cell carcinoma RUFY4 predicts immunotherapy responsiveness in a PDL1-related manner
Journal
Cancer cell international
Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies
Journal
Int J Nanomedicine
Klf4 Promotes Dentinogenesis and Odontoblastic Differentiation via Modulation of TGF‐β Signaling Pathway and Interaction With Histone Acetylation
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomyinduced bone loss
Journal
Phytotherapy research : PTR
Baicalin alleviates chronic obstructive pulmonary disease through regulation of HSP72-mediated JNK pathway
FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6 - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Alantolactone induces apoptosis through ROS-mediated AKT pathway and inhibition of PINK1-mediated mitophagy in human HepG2 cells
Oral or intranasal immunization with recombinant Lactobacillus plantarum displaying head domain of Swine Influenza A virus hemagglutinin protects mice from H1N1 virus - PMC
Journal
Microbial cell factories
Polycyclic polyprenylated acylphloroglucinols from Garcinia xanthochymus fruits exhibit antitumor effects by inhibition of STAT3 signaling pathway
Species
Homo sapiens, Mus musculus
Anti-obesity effects of DHA and EPA in high fat-induced insulin resistant mice
microRNA-130b-3p Contained in MSC-Derived EVs Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis
Journal
Mol Ther Oncolytics
The probiotic Lactobacillus casei Zhang-mediated correction of gut dysbiosis ameliorates peritoneal fibrosis by suppressing macrophage-related inflammation via the
Pectic oligosaccharides ameliorate high-fat diet-induced obesity and hepatic steatosis in association with modulating gut microbiota in mice
Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota
5-heptadecylresorcinol alleviated high-fat diet induced obesity and insulin resistance by activating brown adipose tissue
Potential mechanisms mediating the protective effects of a peptide from walnut (Juglans mandshurica Maxim.) against hydrogen peroxide induced neurotoxicity in PC12 cells
Malvidin and its derivatives exhibit antioxidant properties by inhibiting MAPK signaling pathways to reduce endoplasmic reticulum stress in ARPE-19 cells
Preventive Effect of Pectic Oligosaccharides on Acute Colitis Model Mice: Modulating Epithelial Barrier, Gut Microbiota and Treg/Th17 Balance
Bioactive compound from the Tibetan turnip (Brassica rapa L.) elicited anti-hypoxia effects in OGD/R-injured HT22 cells by activating the PI3K/AKT pathway
Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and upregulation of the PKA/BDNF/NGF signaling pathway
Gardenia jasminoides J. Ellis extract alleviated white matter damage through promoting the differentiation of oligodendrocyte precursor cells via suppressing neuroinflammation
Porcine Circovirus Type 2 Infection Activates NF-κB pathway and Cellular Inflammatory Responses through circPDCD4/miR-21/PDCD4 Axis in Porcine Kidney 15 Cell
N-Myc Downstream-Regulated Gene 1 Facilitates Influenza A Virus Replication by Suppressing Canonical NF-κB Signaling
Comparative transcriptome reveals the effect of IFITM1 on differential resistance to duck hepatitis A virus genotype 3 in Pekin ducks
Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats
Journal
Frontiers in molecular neuroscience
Proteomic analysis of spinal cord tissue in a rat model of cancer-induced bone pain - PMC
Journal
Frontiers in molecular neuroscience
Identification of the key immune-related genes in aneurysmal subarachnoid hemorrhage - PMC
Journal
Frontiers in molecular neuroscience
Systematic identification of potential key microRNAs and circRNAs in the dorsal root ganglia of mice with sciatic nerve injury - PMC
Journal
Frontiers in molecular neuroscience
Salubrinal Protects Against Cisplatin-Induced Cochlear Hair Cell Endoplasmic Reticulum Stress by Regulating Eukaryotic Translation Initiation Factor 2α Signalling - PMC
Journal
Frontiers in molecular neuroscience
Exercise Normalized the Hippocampal Renin-Angiotensin System and Restored Spatial Memory Function, Neurogenesis, and Blood-Brain Barrier Permeability in the 2K1C-Hypertensive Mouse
Journal
International journal of molecular sciences
Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia
Journal
International journal of molecular sciences
Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C-Like Protease by Quercetin
N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells.
Journal
International Journal of Molecular Sciences
Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-Like Mice
Journal
International Journal of Molecular Sciences
The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells.
Journal
International Journal of Molecular Sciences
BmRRS1 Protein Inhibits the Proliferation of Baculovirus Autographa californica Nucleopolyhedrovirus in Silkworm, Bombyx mori - PMC
Journal
International journal of molecular sciences
The Effect of miR-140-5p with HDAC4 towards Growth and Differentiation Signaling of Chondrocytes in Thiram-Induced Tibial Dyschondroplasia - PMC
Journal
International journal of molecular sciences
HuR Promotes the Differentiation of Goat Skeletal Muscle Satellite Cells by Regulating Myomaker mRNA Stability - PMC
Journal
International journal of molecular sciences
Milk-Derived Small Extracellular Vesicles Promote Osteogenic Differentiation and Inhibit Inflammation via microRNA-21 - PMC
Journal
International journal of molecular sciences
Generation of a Novel SORT1×HER2 Bispecific Antibody-Drug Conjugate Targeting HER2-Low-Expression Tumor - PMC
Journal
International journal of molecular sciences
Species
Oryctolagus cuniculus
HSP90AB1 Is a Host Factor Required for Transmissible Gastroenteritis Virus Infection - PMC
Journal
International journal of molecular sciences
Species
Oryctolagus cuniculus
Metformin Attenuates TGF-1-Induced Fibrosis in Salivary Gland: A Preliminary Study - PMC
Journal
International journal of molecular sciences
Species
Homo sapiensRattus norvegicus
METTL3 Promotes the Differentiation of Goat Skeletal Muscle Satellite Cells by Regulating MEF2C mRNA Stability in a m6A-Dependent Manner - PMC
Journal
International journal of molecular sciences
Involvement of Vacuolar Processing Enzyme CgVPE1 in Vacuole Rupture in the Programmed Cell Death during the Development of the Secretory Cavity in Citrus grandis ‘Tomentosa Fruits - PMC
Journal
International journal of molecular sciences
Overexpression of Ultrabithorax Changes the Development of Silk Gland and the Expression of Fibroin Genes in Bombyx mori - PMC
Journal
International journal of molecular sciences
A Putative Receptor for Ferritin in Mollusks: Characterization of the Insulin-like Growth Factor Type 1 Receptor - PMC
Journal
International journal of molecular sciences
Macrophage Migration Inhibitory Factor in Psoroptes ovis: Molecular Characterization and Potential Role in Eosinophil Accumulation of Skin in Rabbit and Its Implication in the Host-Parasite Interaction - PMC
Journal
International journal of molecular sciences
Effects of Maternal High-Fructose Diet on Long Non-Coding RNAs and Anxiety-like Behaviors in Offspring - PMC
Journal
International journal of molecular sciences
siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury - PMC
Journal
International journal of molecular sciences
CircTCF4 Suppresses Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells Independent from AGO2 Binding - PMC
Journal
International journal of molecular sciences
Short-Term Starvation Weakens the Efficacy of Cell Cycle Specific Chemotherapy Drugs through G1 Arrest - PMC
Journal
International journal of molecular sciences
Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes - PMC
Journal
International journal of molecular sciences
Both LTA and LTB Subunits Are Equally Important to Heat-Labile Enterotoxin (LT)-Enhanced Bacterial Adherence - PMC
Journal
International journal of molecular sciences
Effects of Sarcoptes scabiei Translationally Controlled Tumor Protein (TCTP) on Histamine Release and Degranulation of KU812 Cells - PMC
Journal
International journal of molecular sciences
Molecular Characterization, Expression, and Regulatory Signal Pathway Analysis of Inflammasome Component Apoptosis-Associated Speck-like Protein Containing a CARD Domain (ASC) in Large Yellow Croaker (Larimichthys crocea) - PMC
Journal
International journal of molecular sciences
Species
Pseudosciaena crocea
Functional and Expressional Analyses Reveal the Distinct Role of Complement Factor I in Regulating Complement System Activation during GCRV Infection in Ctenopharyngodon idella - PMC
Journal
International journal of molecular sciences
Species
Ctenopharyngodon idella
Inhibition of Oncogenic Src Ameliorates Silica-Induced Pulmonary Fibrosis via PI3K/AKT Pathway - PMC
Journal
International journal of molecular sciences
Ameliorating Effects of Vitamin K2 on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice - PMC
Journal
International journal of molecular sciences
Retinal Proteomic Analysis in a Mouse Model of Endotoxin-Induced Uveitis Using Data-Independent Acquisition-Based Mass Spectrometry - PMC
Journal
International journal of molecular sciences
The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-κB Signalling - PMC
Journal
International journal of molecular sciences
Graphene Oxide Loaded on TiO2-Nanotube-Modified Ti Regulates the Behavior of Human Gingival Fibroblasts - PMC
Journal
International journal of molecular sciences
A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection
Journal
International journal of molecular sciences
Zinc glycine chelate ameliorates DSS-induced intestinal barrier dysfunction via attenuating TLR4/NF-B pathway in meat ducks - PMC
Journal
Journal of animal science and biotechnology
Species
Oryctolagus cuniculus
Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells
Journal
Journal of chemical information and modeling
Parvalbumin-positive neurons in the medial vestibular nucleus contribute to vestibular compensation through commissural inhibition - PMC
Journal
Frontiers in cellular neuroscience
Enhanced recruitment of glutamate receptors underlies excitotoxicity of mitral cells in acute hyperammonemia - PMC
Journal
Frontiers in cellular neuroscience
Orexin-A exerts neuroprotective effect in experimental intracerebral hemorrhage by suppressing autophagy via OXR1-mediated ERK/mTOR signaling pathway - PMC
Journal
Frontiers in cellular neuroscience
Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells
Journal
Chinese medical journal
Transcription factor ASCL1 acts as a novel potential therapeutic target for the treatment of the Cushing's disease
Journal
The Journal of clinical endocrinology and metabolism
L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail
Journal
Journal Of Nutritional Biochemistry
Sesamol promotes browning of white adipocytes through liver-adipose crosstalk signal of hepatic fibroblast growth factor 21
Journal
The Journal of nutritional biochemistry
Species
Homo sapiens, Mus musculus
Moderate Replacement of Fish Oil with Palmitic Acid-Stimulated Mitochondrial Fusion Promotes -oxidation by Mfn2 Interacting with Cpt1 via Its GTPase-domain
Journal
The Journal of nutritional biochemistry
Low vitamin D during pregnancy is associated with infantile eczema by up-regulation of PI3K/AKT/mTOR signaling pathway and affecting FOXP3 expression: A
Journal
The Journal of nutritional biochemistry
Endogenous PTEN acts as the key determinant for mTOR inhibitor sensitivity by inducing the stress-sensitized PTEN-mediated death axis in KSHV-associated malignant cells - PMC
Journal
Frontiers in molecular biosciences
Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway - PMC
Journal
Frontiers in molecular biosciences
Resveratrol inhibits the formation and accumulation of lipid droplets through AdipoQ signal pathway and lipid metabolism lncRNAs
Journal
The Journal of nutritional biochemistry
Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis
Journal
Biochemical pharmacology
USP10 promotes the progression of triple-negative breast cancer by enhancing the stability of TCF4 protein
Journal
Biochemical pharmacology
Gasdermin D promotes hyperuricemia-induced renal tubular injury through RIG-I/caspase-1 pathway - PMC
Identification of lysine-lactylated substrates in gastric cancer cells - PMC
JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia - PMC
NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma - PMC
Commercial dishes with gelatin-free microstructured inserts for elongated stem cell self-renewal and pluripotency - PMC
Effects of lysate/tissue storage at -80°C on subsequently extracted EVs of epithelial ovarian cancer tissue origins - PMC
Envelope virus-mimetic nanovaccines by hybridizing bioengineered cell membranes with bacterial vesicles
Species
Oryctolagus cuniculus
GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry - PMC
Prdm14 promotes mouse ESC self-renewal and PGCLC specification through enhancement of Stat3 activity - PMC
Toxoplasma gondii SAG1 targeting host cell S100A6 for parasite invasion and host immunity
RJT-101, a novel camptothecin derivative, is highly effective in the treatment of melanoma through DNA damage by targeting topoisomerase 1
Journal
Biochemical pharmacology
Oncolytic Vaccinia Virus Expressing White-Spotted Charr Lectin Regulates Antiviral Response in Tumor Cells and Inhibits Tumor Growth In Vitro and In Vivo
The Mechanism of Insulin-Like Growth Factor II mRNA-Binging Protein 3 Induce Decidualization and Maternal-Fetal Interface Cross Talk by TGF-β1 in Recurrent Spontaneous Abortion
Journal
Frontiers in cell and developmental biology
Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape
Journal
Front Cell Dev Biol
Blockage of Autophagic Flux and Induction of Mitochondria Fragmentation by Paroxetine Hydrochloride in Lung Cancer Cells Promotes Apoptosis via the ROS-MAPK Pathway
Journal
Frontiers in Cell and Developmental Biology
Anti-Leukemia Activity of Polysaccharide from Sargassum fusiforme via the PI3K/AKT/BAD Pathway In Vivo and In Vitro - PMC
A Comparative Study of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins in Breast Cancer Cells - PMC
Oncolytic Vaccinia Virus Carrying Aphrocallistes vastus Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells - PMC
Zfp281 Inhibits the Pluripotent-to-Totipotent State Transition in Mouse Embryonic Stem Cells - PMC
Journal
Frontiers in cell and developmental biology
Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Hepatocellular Carcinoma Cells - PMC
Probiotic Bacillus subtilis LF11 Protects Intestinal Epithelium Against Salmonella Infection
Journal
Frontiers in cellular and infection microbiology
Host SUMOylation Pathway Negatively Regulates Protective Immune Responses and Promotes Leishmania donovani Survival - PMC
Journal
Frontiers in cellular and infection microbiology
Inhibition of Porcine Epidemic Diarrhea Virus by Cinchonine via Inducing Cellular Autophagy - PMC
Journal
Frontiers in cellular and infection microbiology
Species
Chlorocebus sabaeus
Campylobacter jejuni Cytolethal Distending Toxin Induces GSDME-Dependent Pyroptosis in Colonic Epithelial Cells
Journal
Frontiers in cellular and infection microbiology
The Immunity Protection of Central Nervous System Induced by Pseudorabies Virus DelgI/gE/TK in Mice
Journal
Frontiers in microbiology
Application of Bioinformatics Analysis to Identify Important Pathways and Hub Genes in Ovarian Cancer Affected by WT1
Journal
Front Bioeng Biotechnol
Identification of an Integrase That Responsible for Precise Integration and Excision of Riemerella anatipestifer Genomic Island.
Journal
Frontiers in Microbiology
Species
Riemerella anatipestifer
The immunity protection of intestine induced by pseudorabies virus del gI/gE/TK in piglets - PMC
Journal
Frontiers in microbiology
Mycobacterium tuberculosis Rv0928 protein facilitates macrophage control of mycobacterium infection by promoting mitochondrial intrinsic apoptosis and ROS-mediated inflammation - PMC
Journal
Frontiers in microbiology
Species
Oryctolagus cuniculus
Porcine Epidemic Diarrhea Virus Infection Subverts Arsenite-Induced Stress Granules Formation - PMC
Journal
Frontiers in microbiology
Species
Chlorocebus aethiops
Liver fat metabolism of broilers regulated by Bacillus amyloliquefaciens TL via stimulating IGF-1 secretion and regulating the IGF signaling pathway - PMC
Journal
Frontiers in microbiology
Transcriptome sequencing and functional verification revealed the roles of exogenous magnesium in tobacco anti-PVY infection - PMC
Journal
Frontiers in microbiology
Fecal microbiota transplantation inhibits colorectal cancer progression: Reversing intestinal microbial dysbiosis to enhance anti-cancer immune responses - PMC
Journal
Frontiers in microbiology
Structural characteristics of locust bean gum hydrolysate and its alleviating effect on dextran sulfate sodium-induced colitis - PMC
Journal
Frontiers in microbiology
Efficient and reversible Cas13d-mediated knockdown with an all-in-one lentivirus-vector - PMC
Journal
Frontiers in bioengineering and biotechnology
Chitosan degradation products promote healing of burn wounds of rat skin - PMC
Journal
Frontiers in bioengineering and biotechnology
Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching
Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats.
Journal
Neural regeneration research
Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring Rats.
Journal
Frontiers in Endocrinology
Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model
Journal
Neural regeneration research
Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis - PMC
Journal
Frontiers in endocrinology
Novel prognostic features and personalized treatment strategies for mitochondria-related genes in glioma patients - PMC
Journal
Frontiers in endocrinology
Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats - PMC
Journal
Frontiers in endocrinology
Screening and Functional Analysis of TPO Gene Mutations in a Cohort of Chinese Patients With Congenital Hypothyroidism
Journal
Frontiers in endocrinology
Salvianolic Acid Ameliorates Pressure Overload-Induced Cardiac Endothelial Dysfunction via Activating HIF1/HSF1/CD31 Pathway
Journal
The American journal of Chinese medicine
Aptamer-modified M cell targeting liposomes for oral delivery of macromolecules
Journal
Colloids and surfaces. B, Biointerfaces
A Novel Modulator of the Renin-Angiotensin System, Benzoylaconitine, Attenuates Hypertension by Targeting ACE/ACE2 in Enhancing Vasodilation and Alleviating Vascular Inflammation
Journal
Frontiers in pharmacology
Species
Homo sapiens, Mus musculus
Network Pharmacology and Molecular Docking-Based Investigation: Prunus mume Against Colorectal Cancer via Silencing RelA Expression
A Polysaccharide From Eupolyphaga sinensis Walker With Anti-HBV Activities In Vitro and In Vivo
Journal
Frontiers in pharmacology
Species
Homo sapiens, Mus musculus
TMI-1, TNF--Converting Enzyme Inhibitor, Protects Against Paclitaxel-Induced Neurotoxicity in the DRG Neuronal Cells In Vitro
Journal
Frontiers in pharmacology
Stachytine Hydrochloride Improves Cardiac Function in Mice with ISO-Induced Heart Failure by Inhibiting the α-1,6-Fucosylation on N-Glycosylation of β1AR
Journal
Frontiers in pharmacology
Number 2 Feibi Recipe Inhibits H 2 O 2 -Mediated Oxidative Stress Damage of Alveolar Epithelial Cells by Regulating the Balance of Mitophagy/Apoptosis
Journal
Frontiers in pharmacology
Hydroxy-Safflower Yellow A Alleviates Osteoporosis in Ovariectomized Rat Model by Inhibiting Carbonic Anhydrase 2 Activity
Circulating Natural Autoantibodies to HER2-Derived Peptides Performed Antitumor Effects on Oral Squamous Cell Carcinoma
Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and K V 1.3 Channels
Transcriptome Analysis of the Inhibitory Effect of Sennoside A on the Metastasis of Hepatocellular Carcinoma Cells
Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β 1-42 Oligomers.
Journal
Frontiers in Pharmacology
Alpiniae oxyphyllae fructus possesses neuroprotective effects on H2O2 stimulated PC12 cells via regulation of the PI3K/Akt signaling Pathway - PMC
Journal
Frontiers in pharmacology
Salvianolic acid B attenuates inflammation and prevent pathologic fibrosis by inhibiting CD36-mediated activation of the PI3K-Akt signaling pathway in frozen shoulder - PMC
Journal
Frontiers in pharmacology
METTL3 promotes drug resistance to oxaliplatin in gastric cancer cells through DNA repair pathway - PMC
Journal
Frontiers in pharmacology
Anti-inflammatory and immunomodulatory effects of polysaccharide extracted from Wuguchong (maggot) on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice - PMC
Journal
Frontiers in pharmacology
Co-delivery of doxorubicin and hydroxychloroquine via chitosan/alginate nanoparticles for blocking autophagy and enhancing chemotherapy in breast cancer therapy - PMC
Journal
Frontiers in pharmacology
Ginsenoside Rc attenuates DSS-induced ulcerative colitis, intestinal inflammatory, and barrier function by activating the farnesoid X receptor - PMC
Journal
Frontiers in pharmacology
Exploring the potential mechanism of Fritiliariae Irrhosae Bulbus on ischemic stroke based on network pharmacology and experimental validation - PMC
Journal
Frontiers in pharmacology
Apol9a regulates myogenic differentiation via the ERK1/2 pathway in C2C12 cells - PMC
Journal
Frontiers in pharmacology
Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo - PMC
Journal
Frontiers in pharmacology
Receptor of Advanced Glycation End Products Deficiency Attenuates Cisplatin-Induced Acute Nephrotoxicity by Inhibiting Apoptosis, Inflammation and Restoring Fatty Acid Oxidation - PMC
Journal
Frontiers in pharmacology
Species
Mus musculus,Rattus norvegicus
Nodosin Exerts an Anti-Colorectal Cancer Effect by Inhibiting Proliferation and Triggering Complex Cell Death in Vitro and in Vivo
- PMC
Journal
Frontiers in pharmacology
Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress - PMC
Journal
Frontiers in pharmacology
Echinacoside Inhibits Osteoclast Function by Down-Regulating PI3K/Akt/C-Fos to Alleviate Osteolysis Caused by Periprosthetic Joint Infection - PMC
Journal
Frontiers in pharmacology
Effects of Periplaneta americana extracts on the growth and proliferation of cutaneous interstitial cells in cutaneous-wound healing - PMC
Journal
Frontiers in pharmacology
The Attenuating Effect of Low-Intensity Pulsed Ultrasound on Hypoxia-Induced Rat Chondrocyte Damage in TMJ Osteoarthritis Based on TMT Labeling Quantitative Proteomic Analysis
Journal
Frontiers in pharmacology
ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer
KCNK levels are prognostic and diagnostic markers for hepatocellular carcinoma.
Electroacupuncture ameliorates AOM/DSS-induced mice colorectal cancer by inhibiting inflammation and promoting autophagy via the SIRT1/miR-215/Atg14 axis - PMC
Species
Mus musculus;Homo sapiens
Xuebijing injection protects sepsis induced myocardial injury by mediating TLR4/NF-B/IKK and JAK2/STAT3 signaling pathways - PMC
Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells - PMC
Species
Oryctolagus cuniculus
Xuebijing injection protects against sepsis-induced myocardial injury by regulating apoptosis and autophagy via mediation of PI3K/AKT/mTOR signaling pathway in rats - PMC
RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma - PMC
mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers
Journal
American Journal of Cancer Research
Circ8199 encodes a protein that inhibits the activity of OGT by JAK2-STAT3 pathway in esophageal squamous cell carcinoma - PMC
Journal
American journal of cancer research
Endogenous HMGB1 regulates GSDME-mediated pyroptosis via ROS/ERK1/2/caspase-3/GSDME signaling in neuroblastoma - PMC
Journal
American journal of cancer research
USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1 - PMC
Journal
American journal of cancer research
The recombinant Erns and truncated E2-based indirect enzyme-linked immunosorbent assays to distinguishably test specific antibodies against classical swine fever virus and bovine viral diarrhea virus - PMC
Species
Sus scrofa,Bos taurus,Danio rerio
The purine receptor P2X7R regulates the release of pro-inflammatory cytokines in human craniopharyngioma
Journal
Endocrine-Related Cancer
PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in the Bone Impairment Caused by Aluminum Exposure
Comparative Study on the Protective Effect of Chlorogenic Acid and 3-(3-Hydroxyphenyl) Propionic Acid against Cadmium-Induced Erythrocyte Cytotoxicity: In Vitro and In Vivo Evaluation
An Early Fecal Microbiota Transfer Improves the Intestinal Conditions on Microflora and Immunoglobulin and Antimicrobial Peptides in Piglets
Journal
Journal of Agricultural and Food Chemistry
Retinoic AcidPPAR Mediates -Carotene Resistance to Placental Dysfunction Induced by Deoxynivalenol
Journal
Journal of agricultural and food chemistry
Astaxanthin Protects against Alcoholic Liver Injury via Regulating Mitochondrial Redox Balance and Calcium Homeostasis
Journal
Journal of agricultural and food chemistry
Protein Phosphorylation Induced by Pyruvate Kinase M2 Inhibited Myofibrillar Protein Degradation in Post-Mortem Muscle
Journal
Journal of agricultural and food chemistry
α-Lipoic Acid Alleviated Fluoride-Induced Hepatocyte Injury via Inhibiting Ferroptosis
Journal
Journal of agricultural and food chemistry
Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease
Journal
Journal of agricultural and food chemistry
Folic Acid Protects against Hyperuricemia in C57BL/6J Mice via Ameliorating Gut–Kidney Axis Dysfunction
Journal
Journal of agricultural and food chemistry
HDAC11 Regulates the Proliferation of Bovine Muscle Stem Cells through the Notch Signaling Pathway and Inhibits Muscle Regeneration
Journal
Journal of agricultural and food chemistry
Insight into Ultrasound-Induced Modifications of the Proteome and Flavor-Related Proteins of Unsmoked Bacon by Applying Label-Free Quantitation Technology
Journal
Journal of agricultural and food chemistry
COL1A1: A potential therapeutic target for colorectal cancer expressing wild-type or mutant KRAS.
Journal
International Journal of Oncology
Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression
Journal
International Journal of Oncology
METTL3 antagonizes 5-FU chemotherapy and confers drug resistance in colorectal carcinoma - PMC
Journal
International journal of oncology
Histone lysine demethylase 3B regulates autophagy via transcriptional regulation of GABARAPL1 in acute myeloid leukemia cells
Journal
International journal of oncology
An Injectable Composite Hydrogel of Verteporfinbonded Carboxymethyl Chitosan and Oxidized Sodium Alginate Facilitates Scarless Fullthickness Skin
Journal
Macromolecular bioscience
SALL1 regulates commitment of odontoblast lineages by interacting with RUNX2 to remodel open chromatin regions
Exosomal circSCMH1/miR-874 ratio in serum to predict carotid and coronary plaque stability - PMC
Journal
Frontiers in cardiovascular medicine
Proteomic and metabolomic analyses reveal the novel targets of spermine for alleviating diabetic cardiomyopathy in type II diabetic mice - PMC
Journal
Frontiers in cardiovascular medicine
Pregestational diabetes alters cardiac structure and function of neonatal rats through developmental plasticity - PMC
Journal
Frontiers in cardiovascular medicine
Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome
Neutrophil extracellular traps facilitate sympathetic hyperactivity by polarizing microglia toward M1 phenotype after traumatic brain injury
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Discovery of novel CDK2 inhibitors using multistage virtual screening and in vitro melanoma cell lines
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Levistolide A Inhibits PEDV Replication via Inducing ROS Generation
Isolation and Identification of Porcine Deltacoronavirus and Alteration of Immunoglobulin Transport Receptors in the Intestinal Mucosa of PDCoV-Infected Piglets
Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83 - PMC
Construction of Attenuated Strains for Red-Spotted Grouper Nervous Necrosis Virus (RGNNV) via Reverse Genetic System - PMC
Species
Mesocricetus auratus
Andrias davidianus Ranavirus (ADRV) Genome Replicate Efficiently by Engaging Cellular Mismatch Repair Protein MSH2
Porcine Deltacoronavirus (PDCoV) Entry into PK-15 Cells by Caveolae-Mediated Endocytosis
Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson's Disease Model
Di (2-ethylhexyl) Phthalate Disturbs Cholesterol Metabolism Through Oxidative Stress In Rat Liver
Journal
Environmental toxicology and pharmacology
Astrocyte-Derived Lipocalin-2 Is Involved in Mitochondrion-Related Neuronal Apoptosis Induced by Methamphetamine
Journal
ACS Chemical Neuroscience
Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach
Journal
Journal of enzyme inhibition and medicinal chemistry
Exosomal CD44 Transmits Lymph Node Metastatic Capacity Between Gastric Cancer Cells via YAP-CPT1A-Mediated FAO Reprogramming
Journal
Frontiers in oncology
Identification and Validation Prognostic Impact of MiRNA-30a-5p in Lung Adenocarcinoma.
Journal
Frontiers in oncology
Myricetin Suppresses Ovarian Cancer In Vitro by Activating the p38/Sapla Signaling Pathway and Suppressing Intracellular Oxidative Stress
Journal
Frontiers in oncology
LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype
Journal
Frontiers in Oncology
p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma.
Journal
Frontiers in Oncology
Oroxylin a Inhibits the Protection of Bone Marrow Microenvironment on CML Cells Through CXCL12/CXCR4/P-gp Signaling Pathway.
Journal
Frontiers in Oncology
Development and validation of a novel anoikis-related gene signature in clear cell renal cell carcinoma - PMC
Journal
Frontiers in oncology
Over-expression of RRM2 predicts adverse prognosis correlated with immune infiltrates: A potential biomarker for hepatocellular carcinoma - PMC
Journal
Frontiers in oncology
Serum-derived piR-hsa-164586 of extracellular vesicles as a novel biomarker for early diagnosis of non-small cell lung cancer - PMC
Journal
Frontiers in oncology
Subunit C of V-ATPase-VmaC Is Required for Hyphal Growth and Conidiation in A. fumigatus by Affecting Vacuolar Calcium Homeostasis and Cell Wall Integration - PMC
Journal
Journal of fungi (Basel, Switzerland)
Artificial Lipid Droplets: Novel Effective Biomaterials to Protect Cells against Oxidative Stress and Lipotoxicity
Journal
Nanomaterials (Basel, Switzerland)
IF1 inactivation attenuates experimental colitis through downregulation of neutrophil infiltration in colon mucosa
Journal
Int Immunopharmacol
Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation
Journal
Int Immunopharmacol
Isodeoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber Linn., inhibits pro-inflammatory mediators' production through both NF-κB and AP-1 pathways in LPS-activated macrophages
Journal
International Immunopharmacology
Inhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy.
Journal
International immunopharmacology
Antidepressant effect of helicid in chronic unpredictable mild stress model in rats.
Journal
International immunopharmacology
Melatonin inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in lipopolysaccharide-induced endometritis in mice
Journal
International Immunopharmacology
Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction
Journal
International Immunopharmacology
Tim-3 deficiency aggravates cadmium nephrotoxicity via regulation of NF-B signaling and mitochondrial damage
Journal
International immunopharmacology
Perillaldehyde: A promising antibacterial agent for the treatment of pneumonia caused by Acinetobacter baumannii infection
Journal
International immunopharmacology
miR-99b-3p/Mmp13 axis regulates NLRP3 inflammasome-dependent microglial pyroptosis and alleviates neuropathic pain via the promotion of autophagy
Journal
International immunopharmacology
PCSK9 inhibitor protects against ischemic cerebral injury by attenuating inflammation via the GPNMB/CD44 pathway
Journal
International immunopharmacology
Hyperandrogenism drives ovarian inflammation and pyroptosis: A possible pathogenesis of PCOS follicular dysplasia
Journal
International immunopharmacology
Aspirin induces immunogenic cell death and enhances cancer immunotherapy in colorectal cancer
Journal
International immunopharmacology
Restoration of miR-328a-5p function curtails hypoxic pulmonary hypertension through a mechanism involving PIN1/GSK3/-catenin axis
Journal
International immunopharmacology
Species
Homo sapiens, Rattus norvegicus
d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice
Journal
International immunopharmacology
AMPK/Drp1 Pathway Mediates Streptococcus Uberis-Induced Mitochondrial Dysfunction
Journal
International immunopharmacology
Mesenchymal stem cell-derived extracellular vesicles carrying miR-99b-3p restrain microglial activation and neuropathic pain by stimulating autophagy
Journal
International immunopharmacology
Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis
Journal
International immunopharmacology
Xanthones from Securidaca inappendiculata Hassk. attenuate collagen-induced arthritis in rats by inhibiting the nicotinamide phosphoribosyltransferase/glycolysis …
Journal
International immunopharmacology
Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury
Journal
International immunopharmacology
G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis - PMC
Journal
Molecular medicine (Cambridge, Mass.)
USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Species
Homo sapiens,Mus musculus
Microbial interventions in yak colibacillosis: Lactobacillus-mediated regulation of intestinal barrier - PMC
Journal
Frontiers in cellular and infection microbiology
Canagliflozin ameliorates the development of NAFLD by preventing NLRP3-mediated pyroptosis through FGF21-ERK1/2 pathway
Journal
Hepatology communications
Ethanol Alleviates Amyloid-β-Induced Toxicity in an Alzheimer's Disease Model of Caenorhabiditis elegans
Journal
Frontiers in aging neuroscience
TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain
A Novel Synthetic Derivative of Phloroglucinol Inhibits Neuroinflammatory Responses Through Attenuating Kalirin Signaling Pathway in Murine BV2 Microglial Cells
Journal
Molecular neurobiology
MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3/-Catenin Signaling and Induce Enteric Glial Cell Apoptosis
Journal
Molecular neurobiology
PTP1B Inhibitor Claramine Rescues Diabetes-Induced Spatial Learning and Memory Impairment in Mice
Journal
Molecular neurobiology
Isobavachalcone's Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3
Journal
Molecular neurobiology
sVCAM1 in the Hippocampus Contributes to Postoperative Cognitive Dysfunction in Mice by Inducing Microglial Activation Through the VLA-4 Receptor
Journal
Molecular neurobiology
Chronic stress-induced elevation of melanin-concentrating hormone in the locus coeruleus inhibits norepinephrine production and associated with
Journal
The international journal of neuropsychopharmacology
Potato StMPK7 is a downstream component of StMKK1 and promotes resistance to the oomycete pathogen Phytophthora infestans
E2F1-mediated ectopic expression of PP1A promotes breast cancer progression via activation of YAP1
Journal
The international journal of biochemistry & cell biology
IRE 1α is critical for Kaempferol‐induced neuroblastoma differentiation
Circular RNAcircLRP6 protects cardiomyocyte from hypoxiainduced apoptosis by facilitating hnRNPMmediated expression of FGF9
Effect of DJ-1 on the neuroprotection of astrocytes subjected to cerebral ischemia/reperfusion injury.
Journal
Journal of molecular medicine (Berlin, Germany)
Inhibition of PKM2 suppresses osteoclastogenesis and alleviates bone loss in mouse periodontitis
Journal
International immunopharmacology
Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K/AKt pathway - PMC
Journal
Arthritis research & therapy
Lactobacillus johnsonii Attenuates Liver Steatosis and Bile Acid Dysregulation in Parenteral Nutrition-Fed Rats - PMC
GAPDH Is a Novel Ferroptosis-Related Marker and Correlates with Immune Microenvironment in Lung Adenocarcinoma - PMC
Protective effect of alpha-lipoic acid on bisphenol A-induced learning and memory impairment in developing mice: nNOS and keap1/Nrf2 pathway
Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network
α-Humulene inhibits hepatocellular carcinoma cell proliferation and induces apoptosis through the inhibition of Akt signaling
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Effects of prenatal acetaminophen exposure at different stages, doses and courses on articular cartilage of offspring mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Silver nanoparticles induced hippocampal neuronal damage involved in mitophagy, mitochondrial biogenesis and synaptic degeneration
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Nrf2-mediated protective effect of alpha-lipoic acid on synaptic oxidative damage and inhibition of PKC/ERK/CREB pathway in bisphenol A-exposed HT-22 cells
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Mitophagy alleviates AIF-mediated spleen apoptosis induced by AlCl3 through Parkin stabilization in mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Melatonin alleviates BDE-209-induced cognitive impairment and hippocampal neuroinflammation by modulating microglia polarization via SIRT1-mediated HMGB1 …
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Respiratory exposure to graphene quantum dots causes fibrotic effects on lung, liver and kidney of mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Nicotinamide N-methyltransferase protects against deoxynivalenol-induced growth inhibition by suppressing pro-inflammatory cytokine expression
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dehydrocostus lactone inhibits the proliferation of esophageal cancer cells in vivo and in vitro through ROS-mediated apoptosis and autophagy
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Learning and memory impairment and transcriptomic profile in hippocampus of offspring after maternal fructose exposure during gestation and lactation
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Transcriptome-Wide Study Revealed That N6-Methyladenosine Participates in Regulation Meat Production in Goats - PMC
Journal
Foods (Basel, Switzerland)
Effect of Peanut Protein Treated with Alkaline Protease and Flavorzyme on BALB/c Mice - PMC
Journal
Foods (Basel, Switzerland)
A bifunctional fusion protein protected against diabetic nephropathy by suppressing NLRP3 activation
Journal
Applied microbiology and biotechnology
Visceral mesenchymal stem cells from type 2 diabetes donors activate triglycerides synthesis in healthy adipocytes via metabolites exchange and cytokines secretion
Journal
International journal of obesity (2005)
Early-Onset Parkinson's Disease and Brain Iron Accumulation Caused by a Novel Homozygous DJ-1 Mutation
Journal
Journal of Parkinson's disease
Atractylenolide III Ameliorated Autophagy Dysfunction via Epidermal Growth Factor Receptor-Mammalian Target of Rapamycin Signals and Alleviated Silicosis
Journal
Laboratory investigation; a journal of technical methods and pathology
A novel autophagy-related gene signature associated with prognosis and immune microenvironment in ovarian cancer - PMC
Journal
Journal of ovarian research
Ubiquitin-specific protease 3 facilitates cell proliferation by deubiquitinating pyruvate kinase L/R in gallbladder cancer
Journal
Laboratory investigation; a journal of technical methods and pathology
The age-related characteristics in bone microarchitecture, osteoclast distribution pattern, functional and transcriptomic alterations of BMSCs in mice
Journal
Mechanisms of ageing and development
Protein acetylation-mediated cross-regulation of acetic acid and ethanol synthesis in the gas-fermenting Clostridium ljungdahlii
Autophagy induced by Vip3Aa has a pro-survival role in Spodoptera frugiperda Sf9 cells
Species
Spodoptera frugiperda
Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-B
Journal
Journal of Immunology (Baltimore, Md. : 1950)
CXCL20a, a Teleost-Specific Chemokine That Orchestrates Direct Bactericidal, Chemotactic, and Phagocytosis-Killing–Promoting Functions, Contributes to Clearance of Bacterial Infections
Synergistic effects of putative Ca2+-binding sites of calmodulin in fungal development, temperature stress and virulence of Aspergillus fumigatus - PMC
Antimicrobial Protein LECT2-b Helps Maintain Gut Microbiota Homeostasis via Selectively Targeting Certain Pathogenic Bacteria
Journal
Journal of immunology (Baltimore, Md. : 1950)
Species
Ctenopharyngodon idellus
Interaction of Nmi and IFP35 Promotes Mutual Protein Stabilization and IRF3 and IRF7 Degradation to Suppress Type I IFN Production in Teleost Fish
Journal
Journal of immunology (Baltimore, Md. : 1950)
CRM197-conjugated peptides vaccine of HCMV pp65 and gH induce maturation of DC and effective viral-specific T cell responses - PMC
Characterization of the pathogenicity of a Bacillus cereus isolate from the Mariana Trench - PMC
Glycosylation on envelope glycoprotein of duck Tembusu virus affects virus replication in vitro and contributes to the neurovirulence and pathogenicity in vivo
PHB2 affects the virulence of Vip3Aa to Sf9 cells through internalization and mitochondrial stability
E. globulus leaf EO exhibits anti-inflammatory effects by regulating GSDMD-mediated pyroptosis, thereby alleviating neurological impairment and neuroinflammation
Journal
Journal of ethnopharmacology
Cornus officinalis var. koreana Kitam extracts alleviate cadmium-induced renal fibrosis by targeting matrix metallopeptidase 9
Journal
Journal of ethnopharmacology
Fine particulate matter (PM2. 5) promotes IgE-mediated mast cell activation through ROS/Gadd45b/JNK axis
Journal
Journal of dermatological science
The role of Huidouba in regulating skeletal muscle metabolic disorders in prediabetic mice through AMPK/PGC-1/PPAR pathway - PMC
Journal
Diabetology & metabolic syndrome
Preclinical Evaluation of a Fluorine-18 (18F)-Labeled Phosphatidylinositol 3-Kinase Inhibitor for Breast Cancer Imaging
Journal
Molecular Pharmaceutics
Brassinosteroid catabolic enzyme CYP734A129 regulates the morphologies of leaves and floral organs in woodland strawberry
Journal
Plant science : an international journal of experimental plant biology
Species
Arabidopsis thaliana
SNORA23 inhibits HCC tumorigenesis by impairing the 2′-O-ribose methylation level of 28S rRNA
Journal
Cancer biology & medicine
DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors
Concentrated growth factor promotes Schwann cell migration partly through the integrin β1-mediated activation of the focal adhesion kinase pathway
Journal
International Journal of Molecular Medicine
Species
Homo sapiens,Rattus norvegicus
Fibronectin 1 inhibits the apoptosis of human trophoblasts by activating the PI3K/Akt signaling pathway
Structural analysis and macrophage activation of a novel β‑glucan isolated from Cantharellus cibarius
lncRNAS56464. 1 as a ceRNA promotes the proliferation of fibroblast‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p
Necrostatin-1 protects C2C12 myotubes from CoCl2-induced hypoxia.
Journal
International Journal of Molecular Medicine
Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats
Journal
International Journal of Molecular Medicine
Sophoricoside attenuates autoimmunemediated liver injury through the regulation of oxidative stress and the NFB signaling pathway
Journal
International journal of molecular medicine
LY294002 alleviates bone cancer pain by reducing mitochondrial dysfunction and the inflammatory response
Journal
International journal of molecular medicine
Curculigoside mitigates dextran sulfate sodium-induced colitis by activation of KEAP1-NRF2 interaction to inhibit oxidative damage and autophagy of intestinal epithelium barrier - PMC
Journal
International journal of molecular medicine
Dihydroartemisinin inhibits the activation and proliferation of hepatic stellate cells by regulating miR-29b-3p - PMC
Journal
International journal of molecular medicine
Synthetic antioxidants from a natural source can overtake the oncogenic stress management system and activate the stress-sensitized death of KSHV-infected cancer cells - PMC
Journal
International journal of molecular medicine
Targeted degradation of CD147 proteins in melanoma
Journal
Bioorganic chemistry
Inula japonica ameliorated bleomycin-induced pulmonary fibrosis via inhibiting soluble epoxide hydrolase
Journal
Bioorganic chemistry
Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1
Journal
Bioorganic Chemistry
Species
Mus musculus,Rattus norvegicus
Identification of N-(3-(methyl (3-(orotic amido) propyl) amino) propyl) oleanolamide as a novel topoisomerase I catalytic inhibitor by rational design, molecular
Journal
Bioorganic chemistry
Calpain-1 mediates vascular remodelling and fibrosis via HIF-1α in hypoxia-induced pulmonary hypertension
Journal
Journal of cellular and molecular medicine
Calpain-1 mediates vascular remodelling and fibrosis via HIF-1α in hypoxia-induced pulmonary hypertension
Journal
Journal of cellular and molecular medicine
The deacetylation of Foxk2 by Sirt1 reduces chemosensitivity to cisplatin
Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice
Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury
Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis
Journal
Journal of Cellular and Molecular Medicine
MicroRNA-129-1-3p protects cardiomyocytes from pirarubicin-induced apoptosis by down-regulating the GRIN2D-mediated Ca2+ signalling pathway
Journal
Journal of Cellular and Molecular Medicine
Species
Mus musculus,Rattus norvegicus
Altered polymerase theta expression promotes chromosomal instability in salivary adenoid cystic carcinoma - PMC
Journal
Journal of cellular and molecular medicine
Glycogen synthase kinase-3 inhibition decreases inflammation and relieves cancer induced bone pain via reducing Drp1-mediated mitochondrial damage - PMC
Journal
Journal of cellular and molecular medicine
Cytochrome P450 enzymes mediated by DNA methylation is involved in deoxynivalenol-induced hepatoxicity in piglets
Journal
Animal nutrition (Zhongguo xu mu shou yi xue hui)
The role of vitamin E in polyunsaturated fatty acid synthesis and alleviating endoplasmic reticulum stress in sub-adult grass carp (Ctenopharyngodon idella)
Journal
Animal nutrition (Zhongguo xu mu shou yi xue hui)
Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop
Journal
American journal of physiology. Cell physiology
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
Ventral hippocampus is more sensitive to fluoxetine-induced changes in extracellular 5-HT concentration, membrane 5-HT transporter level and immobility times
A comprehensive dynamic immune acetylproteomics profiling induced by Puccinia polysora in maize - PMC
Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain
Molecular mechanisms of Chengshi Beixie Fenqing Decoction based on network pharmacology: pivotal roles of relaxin signaling pathway and its associated target …
Journal
Journal of biomolecular structure & dynamics
ABC Transporters and CYP3A4 Mediate Drug Interactions between Enrofloxacin and Salinomycin Leading to Increased Risk of Drug Residues and Resistance - PMC
Journal
Antibiotics (Basel, Switzerland)
Mechanism Underlying Triple VEGFR Inhibitor Tivozanib-Induced Hypertension in Mice Model - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
Antagonism of Protease-Activated Receptor 4 Protects Against Traumatic Brain Injury by Suppressing Neuroinflammation via Inhibition of Tab2/NF-κB Signaling
Unraveling the Protective Role of Nrf2 in Molluscs: Insights into Mitochondrial and Apoptosis Pathways in the Defense Against Bap-induced Oxidative Stress
Journal
Aquatic toxicology (Amsterdam, Netherlands)
Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation
Sophoraflavanone M, a prenylated flavonoid from Sophora flavescens Ait., suppresses pro-inflammatory mediators through both NF-κB and JNK/AP-1 signaling pathways in LPS-primed macrophages
Optimization of ultrasound extraction of Tribulus terrestris L. leaves saponins and their HPLC-DAD-ESI-MSn profiling, anti-inflammatory activity and mechanism in vitro and in vivo
A BET inhibitor, NHWD-870, can downregulate dendritic cells maturation via the IRF7-mediated signaling pathway to ameliorate imiquimod-induced psoriasis-like
Journal
European journal of pharmacology
Species
Homo sapiens,Mus musculus
Polysaccharide from Polygala tenuifolia alleviates cognitive decline in Alzheimer's disease mice by alleviating A damage and targeting the ERK pathway
Journal
Journal of ethnopharmacology
Mechanism of Qizhen decoction-mediated maturation of DC cells to activate the IL-12/JAK2/STAT4 pathway to sensitise PD-1 inhibitors in the treatment of colorectal
Journal
Journal of ethnopharmacology
Modified Xiaoyao San reverses lipopolysaccharide-induced depression-like behavior through suppressing microglia M1 polarization via enhancing autophagy
Journal
Journal of ethnopharmacology
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-B pathway
Journal
European journal of pharmacology
SOX4 as a potential therapeutic target for pathological cardiac hypertrophy
Journal
European journal of pharmacology
'Pterocephalodes hookeri-Onosma hookeri'decoction protects against LPS-induced pulmonary inflammation via inhibiting TLR4/NF-B signaling pathway
Journal
Journal of ethnopharmacology
Analysis of pharmacodynamic components, targets and synergistic action mechanism of Fuyuan Shenghua granule for the treatment of medical-induced incomplete
Journal
Journal of ethnopharmacology
A composition of ursolic acid derivatives from Ludwigia hyssopifolia induces apoptosis in throat cancer cells via the Akt/mTOR and mitochondrial signaling pathways
Journal
Journal of ethnopharmacology
'Yajieshaba'Prevents Acute Alcoholic Liver Injury and Repairs the Intestinal Mucosal Barrier
Journal
Journal of ethnopharmacology
Interpretation of the anti-influenza active ingredients and potential mechanisms of Ge Gen Decoction based on spectrum-effect relationships and network analysis
Journal
Journal of ethnopharmacology
Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway
Journal
European journal of pharmacology
Species
Mus musculus, Rattus norvegicus
Marsdenia tenacissima extract induces endoplasmic reticulum stress-associated immunogenic cell death in non-small cell lung cancer cells through targeting AXL
Journal
Journal of ethnopharmacology
Yinma Jiedu Granule attenuates LPS-induced acute lung injury in rats via suppressing inflammation level
Journal
Journal of ethnopharmacology
Selenium alleviates endoplasmic reticulum calcium depletion-induced endoplasmic reticulum stress and apoptosis in chicken myocardium after mercuric chloride …
Journal
Environmental science and pollution research international
Effect of Radix Polygalae extract on the colonic dysfunction in rats induced by chronic restraint stress
Journal
Journal of ethnopharmacology
Tibetan medicine Si-Wei-Qiang-Wei Powder ameliorates cholecystitis via inhibiting the production of pro-inflammatory cytokines and regulating the MAPK signaling …
Journal
Journal of ethnopharmacology
Polyphenols extracted from Enteromorpha clathrata alleviates inflammation in lipopolysaccharide-induced RAW 264.7 cells by inhibiting the MAPKs/NF-κB signaling pathways
Journal
Journal of ethnopharmacology
Autophagy triggered by the ROS/ERK signaling pathway protects mouse embryonic palatal cells from apoptosis induced by nicotine
Journal
Environmental science and pollution research international
Mahuang Xixin Fuzi decoction ameliorates apoptosis via the mitochondrial-mediated signaling pathway in MCM cells
Journal
Journal of ethnopharmacology
Subacute cadmium exposure modulates Th1 polarization to trigger ER stress-induced porcine hepatocyte apoptosis via regulation of miR-369-TNFα axis
Journal
Environ Sci Pollut Res Int
Helicobacter hepaticus promotes liver fibrosis through oxidative stress induced by hydrogenase in BALB/c mice
Equal distribution of lipid droplets in daughter cells is regulated by microtubules
Journal
Cell cycle (Georgetown, Tex.)
LOXL2 small molecule inhibitor restrains malignant transformation of cervical cancer cells by repressing LOXL2 -induced epithelial-mesenchymal transition (EMT)
Journal
Cell cycle (Georgetown, Tex.)
ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice
Journal
Chem Biol Interact
Effect of e-cigarette refill liquid on follicular development and estrogen secretion in rats
Journal
Tobacco induced diseases
A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages
Journal
Chemico-biological interactions
Carboxylated ε-Poly-l-lysine Improves Post-Thaw Quality, Mitochondrial Functions and Antioxidant Defense of Goat Cryopreserved Sperm
Effect of Sox18 on the Induction Ability of Dermal Papilla Cells in Hu Sheep - PMC
Genistein Sensitizes Human Cholangiocarcinoma Cell Lines to Be Susceptible to Natural Killer Cells - PMC
Downregulation of m6A Methyltransferase in the Hippocampus of Tyrobp -/- Mice and Implications for Learning and Memory Deficits
Journal
Frontiers in neuroscience
Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson's Disease Models
Journal
Frontiers in Neuroscience
KLHDC7B as a novel diagnostic biomarker in urine exosomal mRNA promotes bladder urothelial carcinoma cell proliferation and migration, inhibits apoptosis
Journal
Molecular carcinogenesis
Investigation into the Impact of Proton Pump Inhibitors on Sertraline Transport across the Blood-Brain Barrier
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Species
Homo sapiens ,Mus musculus
Bioactive fraction of Tragia involucrata Linn leaves attenuates inflammation in Freund's complete adjuvant-induced arthritis in Wistar albino rats via inhibiting NF-κB
Journal
Inflammopharmacology
PDL1-Based Nomogram May Be of Potential Clinical Utility for Predicting Survival Outcome in Stage III Breast Cancer - PMC
Journal
Breast cancer (Dove Medical Press)
Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin-p53 interaction - PMC
Investigation on the Pathological Mechanism of Frequent Exacerbators With Chronic Obstructive Pulmonary Disease Based on the Characteristics of Respiratory Flora
Journal
Frontiers in medicine
Amlexanox exerts anti-inflammatory actions by targeting phosphodiesterase 4B in lipopolysaccharide-activated macrophages
Journal
Biochimica et biophysica acta. Molecular cell research
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment
Journal
The Journal of steroid biochemistry and molecular biology
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats
Journal
European journal of pharmacology
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats
Journal
European journal of pharmacology
Sodium butyrate alleviates right ventricular hypertrophy in pulmonary arterial hypertension by inhibiting H19 and affecting the activation of let-7g-5p/IGF1 receptor
Journal
European journal of pharmacology
Transcription factors SltA and CrzA reversely regulate calcium homeostasis under calcium-limited conditions
Journal
Applied and environmental microbiology
Species
A. fumigatus strains
Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway
Journal
Drug development research
Protective Effects of Selenium Nanoparticle-Enriched Lactococcus lactis NZ9000 against Enterotoxigenic Escherichia coli K88-Induced Intestinal Barrier Damage in Mice
Journal
Applied and environmental microbiology
Glycation damage to organelles and their DNA increases during maize seedling development
Journal
Scientific reports
High expression of TCN1 is a negative prognostic biomarker and can predict neoadjuvant chemosensitivity of colon cancer
Fasciclin-like arabinogalactan proteins, PtFLAs, play important roles in GA-mediated tension wood formation in Populus.
Journal
Scientific Reports
Species
Populus davidiana×P.bolleana
UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport
Journal
Scientific Reports
Species
Caenorhabditis Elegans
Network pharmacology combined with experimental verification to explore the potential mechanism of naringenin in the treatment of cervical cancer - PMC
Journal
Scientific reports
CHEK2 is a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma - PMC
Journal
Scientific reports
LncRNA SNHG8 regulates the migration and angiogenesis of pHUVECs induced by high glucose via the TRPM7/ERK1/2 signaling axis - PMC
Journal
Scientific reports
miR-33a-3p regulates METTL3-mediated AREG stability and alters EMT to inhibit pancreatic cancer invasion and metastasis - PMC
Journal
Scientific reports
The apoptotic effects of soybean agglutinin were induced through three different signal pathways by down-regulating cytoskeleton proteins in IPEC-J2 cells - PMC
Journal
Scientific reports
Gut microbiota induces hepatic steatosis by modulating the T cells balance in high fructose diet mice - PMC
Journal
Scientific reports
Integrated multiple microarray studies by robust rank aggregation to identify immune-associated biomarkers in Crohn's disease based on three machine learning methods - PMC
Journal
Scientific reports
Lentinan improves intestinal inflammation and gut dysbiosis in antibiotics-induced mice - PMC
Journal
Scientific reports
Genipin improves reproductive health problems caused by circadian disruption in male mice
Journal
Reprod Biol Endocrinol
miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4 - PMC
Journal
Reproductive biology and endocrinology : RB&E
The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia - PMC
Journal
Reproductive biology and endocrinology : RB&E
Heterologous expression and comparative characterization of vacuolar invertases from Cu-tolerant and non-tolerant populations of Elsholtzia haichowensis
Journal
Plant cell reports
Design and Fabrication of Nanofibrous Dura Mater with Antifibrosis and Neuroprotection Effects on SH-SY5Y Cells
Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier-Dependent Manner
Dioscin Inhibits the Invasion and Migration of Hepatocellular Carcinoma HepG2 Cells by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition.
A Single-Pass Type I Membrane Protein from the Apicomplexan Parasite Cryptosporidium parvum with Nanomolar Binding Affinity to Host Cell Surface
Species
Cryptosporidium parvum
Cepharanthine Exerts Antioxidant and Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Macrophages and DSS-Induced Colitis Mice - PMC
Journal
Molecules (Basel, Switzerland)
Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 Pathway - PMC
Journal
Molecules (Basel, Switzerland)
Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions - PMC
Journal
Molecules (Basel, Switzerland)
Promotion of Deoxycholic Acid Effect on Colonic Cancer Cell Lines In Vitro by Altering the Mucosal Microbiota - PMC
Siniperca chuatsi Rhabdovirus (SCRV)-Induced Key Pathways and Major Antiviral Genes in Fish Cells - PMC
In Vitro Anticancer Activity of Methanolic Extract of Justicia adhatoda Leaves with Special Emphasis on Human Breast Cancer Cell Line - PMC
Journal
Molecules (Basel, Switzerland)
Integrated Analysis of Transcriptome and microRNA Profile Reveals the Toxicity of Euphorbia Factors toward Human Colon Adenocarcinoma Cell Line Caco-2 - PMC
Journal
Molecules (Basel, Switzerland)
Hepatoprotective Activity of Ethanol Extract of Rice Solid-State Fermentation of Ganoderma tsugae against CCl4-Induced Acute Liver Injury in Mice - PMC
Journal
Molecules (Basel, Switzerland)
First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor - PMC
Journal
Molecules (Basel, Switzerland)
Investigation Driven by Network Pharmacology on Potential Components and Mechanism of DGS, a Natural Vasoprotective Combination, for the Phytotherapy of Coronary Artery Disease - PMC
Journal
Molecules (Basel, Switzerland)
Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway - PMC
MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting ROR in nucleus pulposus cells
Journal
Cellular signalling
LukS-PV inhibits the proliferation of hepatocellular carcinoma cells by maintaining FOXO3 stability via the PI3K/AKT signaling pathway
Journal
Cellular signalling
Anlotinib exerts an anti-T-cell acute lymphoblastic leukemia effect in vitro and in vivo
Journal
Cellular signalling
LncRNA CARMN suppresses EMT through inhibiting transcription of MMP2 activated by DHX9 in breast cancer
Journal
Cellular signalling
HDAC1 inhibits beige adipocyte-mediated thermogenesis through histone crotonylation of Pgc1a/Ucp1
Journal
Cellular signalling
Rutin prevents inflammation induced by lipopolysaccharide in RAW 264.7 cells via conquering the TLR4-MyD88-TRAF6-NF-κB signalling pathway
Journal
The Journal of pharmacy and pharmacology
miR-1182-mediated ALDH3A2 inhibition affects lipid metabolism and progression in ccRCC by activating the PI3K-AKT pathway
Journal
Translational oncology
Species
Oryctolagus cuniculus
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer in Vitro and …
Journal
Journal of natural products
Myrtenal and β-caryophyllene oxide screened from Liquidambaris Fructus suppress NLRP3 inflammasome components in rheumatoid arthritis
Journal
BMC Complement Med Ther
Identifying Candidate Genes for Short Gestation Length Trait in Chinese Qingping Pigs by Whole-Genome Resequencing and RNA Sequencing - PMC
Journal
Frontiers in genetics
Nucleo-cytoplasmic RNA distribution responsible for maintaining neuroinflammatory microenvironment
Leader RNA regulates snakehead vesiculovirus replication via interacting with viral nucleoprotein
Species
Ictalurus punctatus
Expression of Na+/K+-ATPase Was Affected by Salinity Change in Pacific abalone Haliotis discus hannai.
Journal
Frontiers in Physiology
Ficus carica L. Attenuates Denervated Skeletal Muscle Atrophy via PPARα/NF-κB Pathway
The mTORC1/eIF4E/HIF-1α Pathway Mediates Glycolysis to Support Brain Hypoxia Resistance in the Gansu Zokor, Eospalax cansus
High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal HIF2a/Iron-Metabolism Pathway - PMC
Loss of the Novel Mitochondrial Membrane Protein FAM210B Is Associated with Hepatocellular Carcinoma - PMC
G1 phase cell cycle arrest in NSCLC in response to LZ-106, an analog of enoxacin, is orchestrated through ROS overproduction in a P53-dependent manner
TPD52L2 impacts proliferation, invasiveness and apoptosis of glioblastoma cells via modulation of wnt/β-catenin/snail signaling
circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p
Journal
Transl Lung Cancer Res
ZHX2 mediates proteasome inhibitor resistance via regulating nuclear translocation of NF‐κB in multiple myeloma
Activation of PI3K/Akt pathway by G proteincoupled receptor 37 promotes resistance to cisplatininduced apoptosis in nonsmall cell lung cancer
Pan‐cancer analysis of oncogenic role of insulin‐like growth factor‐binding proteins and validation in ovarian cancer
RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial-protective effects of metformin under high glucose in HUVECs.
Visfatin Exerts Immunotherapeutic Effects in Lipopolysaccharide-Induced Acute Lung Injury in Murine Model
L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway
Journal
Nutrition & metabolism
Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets
Journal
Nutrition & Metabolism
Human umbilical cord mesenchymal stem cells repair endothelial injury and dysfunction by regulating NLRP3 to inhibit endothelial cell pyroptosis in Kawasaki
Species
Homo sapiens,Mus musculus
BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis
Up-Regulation Thioredoxin Inhibits Advanced Glycation End Products-Induced Neurodegeneration.
Journal
Cellular physiology and biochemistry
Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation
SJMHE1 peptide from Schistosoma japonicum inhibits asthma in mice by regulating Th17/Treg cell balance via miR-155
Journal
Journal of inflammation research
Curcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a
Upregulation of Neuronal Cylindromatosis Expression is Essential for Electroacupuncture-Mediated Alleviation of Neuroinflammatory Injury by Regulating Microglial Polarization in Rats Subjected to Focal Cerebral Ischemia/Reperfusion
PLCD3 promotes malignant cell behaviors in esophageal squamous cell carcinoma via the PI3K/AKT/P21 signaling - PMC
The mitochondrial fusion-associated protein MFN2 can be used as a novel prognostic molecule for clear cell renal cell carcinoma - PMC
Species
Oryctolagus cuniculus
Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation - PMC
Identification and in vitro and in vivo validation of the key role of GSDME in pyroptosis-related genes signature in hepatocellular carcinoma - PMC
Mesenchymal Stem Cells Ameliorate DSS-Induced Experimental Colitis by Modulating the Gut Microbiota and MUC-1 Pathway - PMC
Journal
Journal of inflammation research
LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells - PMC
Species
Rattus norvegicus,Bos taurus
Transcriptomic analysis reveals the effects of maternal selenium deficiency on placental transport, hormone synthesis, and immune response in mice
Journal
Metallomics : integrated biometal science
Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice
Journal
Metallomics : integrated biometal science
S-nitrosoglutathione reductase-dependent p65 denitrosation promotes osteoclastogenesis by facilitating recruitment of p65 to NFATc1 promoter
Induction of autophagy via the ROS-dependent AMPK/mTOR pathway protects deoxynivalenol exposure grass carp hepatocytes damage
Journal
Fish & shellfish immunology
Species
Ctenopharyngodon idellus
Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs
Journal
Fish & shellfish immunology
Species
Oryctolagus cuniculus
Prohibitin mediates the cellular invasion of spring viremia of the carp virus
Journal
Fish & shellfish immunology
Functional and expression analysis reveals the involvement of integrin αvβ3 in antiviral immunity of grass carp (Ctenopharyngodon idella)
Journal
Fish & shellfish immunology
Expression profile, subcellular localization of MARCH4 and transcriptome analysis of its potential regulatory signaling pathway in large yellow croaker (Larimichthys …
Journal
Fish & shellfish immunology
Isolation and characterization of plasma-derived exosomes from olive flounder (Paralichthys olivaceus) and their wound healing and regeneration activities
Journal
Fish & shellfish immunology
Ephrin type-B receptor 4 affinity chromatography: An effective and rapid method studying the active compounds targeting Ephrin type-B receptor 4.
Journal
Journal of chromatography. A
Isocitrate dehydrogenase 2 regulates the proliferation of triple-negative breast cancer through the ferroptosis pathway - PMC
Journal
Scientific reports
Targeting TAOK1 with resveratrol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo
Journal
Molecular carcinogenesis
Species
Oryctolagus cuniculus
Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp hepatocytes
Journal
Fish Shellfish Immunol
Species
Ctenopharyngodon idellus
Functional characterization of a putative lipopolysaccharide-induced TNF-alpha factor (LITAF) from blood clam Tegillarca granosa in innate immunity
Journal
Fish & Shellfish Immunology
Species
Tegillarca granosa
Sequence and expression analysis of the cytoplasmic pattern recognition receptor melanoma differentiation-associated gene 5 from the barbel chub Squaliobarbus curriculus.
Journal
Fish & shellfish immunology
Species
Squaliobarbus curriculus
Soluble adenylyl cyclase mediates mitochondrial pathway of apoptosis and ATP metabolism in oyster Crassostrea gigas exposed to elevated CO2
Journal
Fish & shellfish Immunology
The receptor for activated C kinase 1 (RACK1) functions in hematopoiesis through JNK activation in Chinese mitten crab Eriocheir sinensis
Journal
Fish & shellfish Immunology
Cadmium exposure induces TNF-α-mediated necroptosis via FPR2/TGF-β/NF-κB pathway in swine myocardium
Resveratrol protects against deoxynivalenol-induced ferroptosis in HepG2 cells
The novel polyfluoroalkyl benzenesulfonate OBS exposure induces cell cycle arrest and senescence of rat pituitary cell GH3 via the p53/p21/RB pathway
The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model - PMC
Journal
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
Effect of liraglutide on endoplasmic reticulum stress in the renal tissue of type 2 diabetic rats
RNA-Seq reveals miRNA role in thermogenic regulation in brown adipose tissues of goats
Identification of Fangjihuangqi Decoction as a late-stage autophagy inhibitor with an adjuvant anti-tumor effect against non-small cell lung cancer - PMC
Ssc-mir-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene - PMC
Integrated analysis of miRNAs and mRNA profiling reveals the potential roles of miRNAs in sheep hair follicle development - PMC
Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling
Giardia duodenalis Induces Apoptosis in Intestinal Epithelial Cells via Reactive Oxygen Species-Mediated Mitochondrial Pathway In Vitro
Species
Giardia duodenalis
Oridonin Inhibits Mycobacterium marinum Infection-Induced Oxidative Stress In Vitro and In Vivo - PMC
Journal
Pathogens (Basel, Switzerland)
lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway - PMC
Journal
Mediators of inflammation
Overexpression and potential roles of midkine via regulation of vascular endothelial growth factor A in psoriasis
Journal
Experimental dermatology
New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesis - PMC
Species
Oryctolagus cuniculus
Syringaldehyde Exhibits Antibacterial and Antioxidant Activities against Mycobacterium marinum Infection - PMC
Loss of Lactate/Proton Monocarboxylate Transporter 4 Induces Ferroptosis via the AMPK/ACC Pathway and Inhibition of Autophagy on Human Bladder Cancer 5637 Cell Line - PMC
Journal
Journal of oncology
FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells - PMC
Journal
Journal of immunology research
MiR2223p suppresses C2C12 myoblast proliferation and differentiation via the inhibition of IRS1/PI3K/Akt pathway
Journal
Journal of cellular biochemistry
Adipose mesenchymal stem cell-derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt/β-catenin signaling in cutaneous wound healing.
Journal
Journal of cellular biochemistry
Bai-He-Gu-Jin-Tang formula suppresses lung cancer via AKT/GSK3β/β-catenin and induces autophagy via the AMPK/mTORC1/ULK1 signaling pathway
EPS15-AS1 Inhibits AKR1B1 Expression to Enhance Ferroptosis in Hepatocellular Carcinoma Cells - PMC
N-Acetyl-L-Cysteine Ameliorates BPAF-Induced Porcine Sertoli Cell Apoptosis and Cell Cycle Arrest via Inhibiting the ROS Level - PMC
Circular RNA hsa_circ_0005239 contributes to hepatocellular carcinoma cell migration, invasion, and angiogenesis by targeting the miR‐34a‐5p/PD‐L1 axis
Journal
Cell biology international
Spleen Toxicity of Organophosphorus Flame Retardant TDCPP in Mice and the Related Mechanisms - PMC
KIF4A drives gliomas growth by transcriptional repression of Rac1/Cdc42 to induce cytoskeletal remodeling in glioma cells - PMC
OSU‐T315 and doxorubicin synergistically induce apoptosis via mitochondrial pathway in bladder cancer cells
Journal
Cell biology international
Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway
Journal
Toxicology and applied pharmacology
Species
Mus musculus,Rattus norvegicus
Identification of Fangchinoline as a novel autophagy inhibitor with an adjuvant of chemotherapy against lung cancer
Journal
Toxicology and applied pharmacology
Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway
Journal
Toxicol Appl Pharmacol
Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure
Journal
Toxicol Appl Pharmacol
Cyanidin prevents the hyperproliferative potential of fibroblast-like synoviocytes and disease progression via targeting IL-17A cytokine signalling in rheumatoid arthritis
Journal
Toxicology and Applied Pharmacology
Paternal high-fat diet altered SETD2 gene methylation in sperm of F0 and F1 mice - PMC
Activation of PPAR-β/δ Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model
Journal
Neurochemical Research
The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Journal
Neurochemical research
Application
WB, IHC, ELISA
Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
Journal
Psychopharmacology
Identification of the miR-423-3p/VLDLR Regulatory Network for Glioma Using Transcriptome Analysis
Journal
Neurochemical research
Histone acetyltransferase Sas3 contributes to fungal development, cell wall integrity, and virulence in Aspergillus fumigatus
Journal
Applied and environmental microbiology
Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion
Journal
The Journal of pharmacology and experimental therapeutics
Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF- mediated activation of NLRP3 inflammasome
Creatine ameliorates high-fat diet-induced obesity by regulation of lipolysis and lipophagy in brown adipose tissue and liver
Silencing RPL8 inhibits the progression of hepatocellular carcinoma by down-regulating the mTORC1 signalling pathway
Establishment and characterization of the third non-functional human pancreatic neuroendocrine tumor cell line
Establishment and characterization of the third non-functional human pancreatic neuroendocrine tumor cell line
Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells.
Journal
Molecular and Cellular Endocrinology
Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior
MiRNA-1225 Inhibits Osteosarcoma Tumor Growth and Progression by Targeting YWHAZ.
Long Noncoding RNA ADAMTS9-AS2 Inhibits the Proliferation, Migration, and Invasion in Bladder Tumor Cells
Downregulation of the Helicase Lymphoid-Specific (HELLS) Gene Impairs Cell Proliferation and Induces Cell Cycle Arrest in Colorectal Cancer Cells.
Journal
OncoTargets and therapy
Se-Enriched Cordyceps militaris Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells.
Journal
OncoTargets and therapy
HSP90 Inhibitor Ganetespib (STA-9090) Inhibits Tumor Growth in c-Myc-Dependent Esophageal Squamous Cell Carcinoma
Journal
Oncotargets and Therapy
Cadmium exposure induces mitochondrial pathway apoptosis in swine myocardium through xenobiotic receptors-mediated CYP450s activation
Journal
Journal of inorganic biochemistry
Malus micromalus Makino phenolic extract preserves hepatorenal function by regulating PKC-α signaling pathway and attenuating endoplasmic reticulum stress in lead (II) exposure mice
Journal
Journal of Inorganic Biochemistry
Species
Mus musculus,Malus micromalus
Effective Spatial Separation of PC12 and NIH3T3 Cells by the Microgrooved Surface of Biocompatible Polymer Substrates
Prion Protein Protects Cancer Cells against Endoplasmic Reticulum Stress Induced Apoptosis.
RNA-Seq-based transcriptomics analysis during the photodynamic therapy of primary cells in secondary hyperparathyroidism
Journal
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment
Journal
Drug Des Devel Ther
N-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264. 7 Cell Osteoclastogenesis
Journal
Drug Des Devel The
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma
Journal
Drug Des Devel Ther
5-Fluorouracil Combined with Rutaecarpine Synergistically Suppresses the Growth of Colon Cancer Cells by Inhibiting STAT3 - PMC
Journal
Drug design, development and therapy
Species
Homo sapiens, Mus musculus
A potential correlation between adipokines, skeletal muscle function and bone mineral density in middle-aged and elderly individuals - PMC
Journal
Lipids in health and disease
Network Pharmacology Analysis of the Mechanisms Underlying the Therapeutic Effects of Yangjing Zhongyu Tang on Thin Endometrium - PMC
Journal
Drug design, development and therapy
A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells - PMC
Journal
Drug design, development and therapy
Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model - PMC
Journal
World journal of gastroenterology
Umbelliferone protects against cerebral ischemic injury through selective autophagy of mitochondria
Journal
Neurochemistry international
1, 8-cineole decreases neuropathic pain probably via a mechanism mediating P2X3 receptor in the dorsal root ganglion
Journal
Neurochemistry international
Aurantio-obtusin induces hepatotoxicity through activation of NLRP3 inflammasome signaling
CDK5-mediated Tau Accumulation Triggers Methamphetamine-induced Neuronal Apoptosis via Endoplasmic Reticulum-Associated Degradation Pathway
Journal
Toxicology Letters
Molecular genetic analysis and growth hormone treatment in a three-generation Chinese family with Tricho-rhino-phalangeal syndrome I
Journal
Hormone research in paediatrics
Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo
Journal
Toxicology letters
Lanthanum Chloride Impairs Learning and Memory and Induces Dendritic Spine Abnormality by Down-Regulating Rac1/PAK Signaling Pathway in Hippocampus of Offspring Rats
Journal
Cellular and Molecular Neurobiology
Dynamic analysis of gene signatures in the progression of COPD - PMC
Mild Hypothermia Alleviates Complement C5a-Induced Neuronal Autophagy During Brain Ischemia–Reperfusion Injury After Cardiac Arrest
Journal
Cellular and molecular neurobiology
Novel functional mutation of the PDIA3 gene affects milk composition traits in Chinese Holstein cattle
Journal
Journal of dairy science
Antiviral and anti-inflammatory activity of novel belladonna formulation against Japanese encephalitis virus via inhibition of p65 nuclear translocation and TNF-α …
Journal
Biotechnology & genetic engineering reviews
MiR-4953p attenuates cell pyroptosis and endometritis through inhibiting the activation of NLRP3 inflammasome in bovine
Journal
Molecular immunology
Downregulation of HHLA2 inhibits ovarian cancer progression via the NF-B signaling pathway and suppresses the expression of CA9
Journal
Cellular immunology
Inhibition of Hexokinase 2 with 3-BrPA Promotes MDSCs Differentiation and Immunosuppressive function
Journal
Cellular immunology
TBC1D21 is an essential factor for sperm mitochondrial sheath assembly and male fertility
Journal
Biology of reproduction
Insulin-like growth factor 1 promotes the gonadal development of Pampus argenteus by regulating energy metabolism
Journal
Biology of reproduction
Construction and efficacy of a new live chimeric C-strain vaccine with DIVA characteristics against classical swine fever
Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man
Journal
Biology of reproduction
Extracellular vesicles derived from astrocytes facilitated neurite elongation by activating the Hippo pathway
PDRG1 predicts a poor prognosis and facilitates the proliferation and metastasis of colorectal cancer
Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells
Vimentin loss promotes cancer proliferation through up-regulating Rictor/AKT/β-catenin signaling pathway
Survivin regulated by autophagy mediates hyperglycemia-induced vascular endothelial cell dysfunction
Journal
Experimental Cell Research
BMP7 Functions to Regulate Proliferation of Dermal Papilla Cells in Hu Sheep
Species
Bos Taurus,Homo sapiens,Mus musculus
Pcsk6 Deficiency Promotes Cardiomyocyte Senescence by Modulating Ddit3-Mediated ER Stress
Species
Mus musculus,Rattus norvegicus
miR-24-3p Dominates the Proliferation and Differentiation of Chicken Intramuscular Preadipocytes by Blocking ANXA6 Expression
An Alternatively Spliced Variant of METTL3 Mediates Tumor Suppression in Hepatocellular Carcinoma
Effect of CUX1 on the Proliferation of Hu Sheep Dermal Papilla Cells and on the Wnt/β-Catenin Signaling Pathway - PMC
Small Extracellular Vesicles of M1-BV2 Microglia Induce Neuronal PC12 Cells Apoptosis via the Competing Endogenous Mechanism of CircRNAs - PMC
Heptadecanoic acid inhibits cell proliferation in PC‑9 non‑small‑cell lung cancer cells with acquired gefitinib resistance
Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway
Platelet‑derived growth factor‑BB mediates pancreatic cancer malignancy via regulation of the Hippo/Yes‑associated protein signaling pathway
PRIMA‑1 met induces autophagy in colorectal cancer cells through upregulation of the mTOR/AMPK‑ULK1‑Vps34 signaling cascade
Platelet-derived growth factor-BB mediates pancreatic cancer malignancy via regulation of the Hippo/Yes-associated protein signaling pathway.
SRSF6 regulates alternative splicing of genes involved in DNA damage response and DNA repair in HeLa cells
PTEN downregulates WD repeat‑containing protein 66 in salivary adenoid cystic carcinoma.
Phosphorylation of nucleolin is indispensable to its involvement in the proliferation and migration of non-small cell lung cancer cells.
CDC6 may serve as an indicator of lung adenocarcinoma prognosis and progression based on TCGA and GEO data mining and experimental analyses
GNPNAT1 promotes the stemness of breast cancer and serves as a potential prognostic biomarker - PMC
Azurocidin 1 inhibits the aberrant proliferation of triplenegative breast cancer through the regulation of pyroptosis
Heat shock protein B7 (HSPB7) inhibits lung adenocarcinoma progression by inhibiting glycolysis - PMC
Study on the Anti-InflammatoryEffect and Mechanismof Yuxuebi Tablet Based on Network Pharmacology - PMC
Linc-ROR Regulates POU5F1 and SOX2 by Competitively Binding miR-145-5p to Affect the Proliferation and Migration of Gastric Cancer Cells - PMC
Journal
Cell transplantation
GC‑MSC‑derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via fatty acid oxidation metabolic reprogramming mediated by the miR‑5572/6855 …
CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker
Network Pharmacology-Based Analysis on the Effects and Mechanism of the Wang-Bi Capsule for Rheumatoid Arthritis and Osteoarthritis
Chemical composition and protective effect of guava (Psidium guajava L.) leaf extract on piglet intestines
Konjac flour-mediated gut microbiota alleviates insulin resistance and improves placental angiogenesis of obese sows - PMC
Oat glucan alleviates muscle atrophy via promoting myotube formation and suppressing protein degradation
Journal
Journal of the science of food and agriculture
Fatty acylCoA synthetase FadD13 regulates proinflammatory cytokine secretion dependent on the NF-κB signalling pathway by binding to eEF1A1.
Journal
Cellular microbiology
Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress
Journal
Arch Biochem Biophys
MiR-95-3p/EPM2A/MMP2 contributes to the pathogenesis of severe preeclampsia through the regulation of trophoblast biological behaviour
Journal
Archives of biochemistry and biophysics
An integrative method for evaluating the biological effects of nanoparticle-protein corona
Journal
Biochimica et biophysica acta. General subjects
Species
Oryctolagus cuniculus
MiR4943p aggravates pirarubicininduced cardiomyocyte injury by regulating MDM4/p53 signaling pathway
Journal
Environmental toxicology
Tanshinone IIA-regulation of IL-6 antagonizes PM 2 .5 -induced proliferation of human bronchial epithelial cells via a STAT3/miR-21 reciprocal loop
Journal
Environmental toxicology
Developing a novel calcium magnesium silicate/graphene oxide incorporated silk fibroin porous scaffold with enhanced osteogenesis, angiogenesis and inhibited osteoclastogenesis
Journal
Biomedical materials (Bristol, England)
Species
Mus musculus,Homo sapiens,Rattus norvegicus
Effects of Inorganic and Organic Manganese Supplementation on Growth Performance, Tibia Development, and Oxidative Stress in Broiler Chickens
Journal
Biol Trace Elem Res
Aberrant Gene Expression of Selenoproteins in Chicken Spleen Lymphocytes Induced by Mercuric Chloride
Journal
Biol Trace Elem Res
Hexavalent Chromium Causes Apoptosis and Autophagy by Inducing Mitochondrial Dysfunction and Oxidative Stress in Broiler Cardiomyocytes
Journal
Biol Trace Elem Res
Altered expression of long noncoding RNA MEG3 in the offspring of gestational diabetes mellitus induces impaired glucose tolerance in adulthood
Journal
Acta diabetologica
Subacute Cadmium Exposure Induces Necroptosis in Swine Lung via Influencing Th1/Th2 Balance
Journal
Biological trace element research
LINGO-1 shRNA loaded by Pluronic F-127 promotes functional recovery after ventral root avulsion.
Journal
Tissue engineering. Part A
Sialin mediates submandibular gland regeneration ability by affecting polysialic acid synthesis
microRNA‐491‐5p regulates osteogenic differentiation of bone marrow stem cells in type 2 diabetes
Enterococcus faecium HDRsEf1 inhibits LPS‐induced downregulation of ZO‐1 expression via TLR2/4‐mediated JNK/AP‐1 signalling pathways
Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration
Oroxylin a glucuronide as a novel class of reversible inhibitors of Sortase a, combats MRSA-induced infections
Journal
Journal of applied microbiology
Species
Staphylococcus aureus
Anti-infection roles of miR-155-5p packaged in exosomes secreted by dendritic cells infected with Toxoplasma gondii
Journal
Parasites & vectors
Recombinant protein EBI3 attenuates Clonorchis sinensis-induced liver fibrosis by inhibiting hepatic stellate cell activation in mice - PMC
Journal
Parasites & vectors
Neospora caninum infection induced mitochondrial dysfunction in caprine endometrial epithelial cells via downregulating SIRT1 - PMC
Journal
Parasites & vectors
A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4-ROS-NLRP3 pathway - PMC
Journal
Parasites & vectors
CpG oligodeoxynucleotides inhibit the proliferation and osteoclastic differentiation of RAW264. 7 cells
Intermittent mild cold stimulation improves the immunity and cold resistance of spleens in broilers
Selenium relieves oxidative stress, inflammation, and apoptosis within spleen of chicken exposed to mercuric chloride
Differential proteomic analysis to identify proteins associated with beak deformity in chickens1.
The function of carnosic acid in lipopolysaccharides-induced hepatic and intestinal inflammation in poultry - PMC
Aminoguanidine alleviates gout in goslings experimentally infected with goose astrovirus-2 by reducing kidney lesions - PMC
Effects of intermittent cold stimulation on growth performance, meat quality, antioxidant capacity and liver lipid metabolism in broiler chickens - PMC
Ligusticum chuanxiong promotes the angiogenesis of preovulatory follicles (F1-F3) in late-phase laying hens
Increased SERPINA3 Level Is Associated with Ulcerative Colitis
Journal
Diagnostics (Basel)
Overexpression of UHRF1 promoted the proliferation of vascular smooth cells via the regulation of Geminin protein levels.
Journal
Bioscience Reports
The interaction between the histone acetyltransferase complex Hat1‐Hat2 and transcription factor AmyR provides a molecular brake to regulate amylase gene …
Journal
Molecular microbiology
Species
Saccharomyces cerevisiae
LncRNA FGD5-AS1 reduces cardiomyocyte apoptosis and inflammation by modulating Akt and miR-223-3p expression - PMC
Journal
American journal of translational research
Pathogenic role of circulating CD4+ CXCR5+ cell subpopulations in patients with chronic spontaneous urticarial
Journal
American journal of translational research
Cardioprotection of an IK1 channel agonist on L-thyroxine induced rat ventricular remodeling
Probiotics alleviate cognitive dysfunction associated with neuroinflammation in cardiac surgery.
Journal
American Journal of Translational Research
Cyanidin attenuates IL-17A cytokine signaling mediated monocyte migration and differentiation into mature osteoclasts in rheumatoid arthritis
Schaftoside reduces inflammation in Aspergillus fumigatus keratitis through the inhibition of the TLR4/MyD88 pathway
Zebrafish ubiquitin-specific peptidase 5 (USP5) activates interferon resistance to the virus by increase the expression of RIG-I
Validation and bioinformatic analysis of propofol-induced differentially expressed microRNAs in primary cultured neural stem cells
LZ-106, a potent lysosomotropic agent, causing TFEB-dependent cytoplasmic vacuolization
hnRNPDL extensively regulates transcription and alternative splicing.
Running Improves Muscle Mass by Activating Autophagic Flux and Inhibiting Ubiquitination Degradation in Mdx Mice
Sesamol intervention ameliorates obesity-associated metabolic disorders by regulating hepatic lipid metabolism in high-fat diet-induced obese mice.
Journal
Food & Nutrition Research
Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway - PMC
Journal
Pharmaceutical biology
A synthetic peptide AWRK6 ameliorates metabolic associated fatty liver disease: involvement of lipid and glucose homeostasis
Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer model via activation of the MAPK-JNK/c-Jun signaling pathway
Journal
Molecular and cellular biochemistry
Rutin protects against pirarubicin-induced cardiotoxicity by adjusting microRNA-125b-1-3p-mediated JunD signaling pathway
Journal
Molecular and Cellular Biochemistry
miR-342-5p targets CTNNBIP1 to promote enterovirus 71 replication
Journal
Microbial pathogenesis
Species
Oryctolagus cuniculus
Exosome miRNA-203 promotes M1 macrophage polarization and inhibits prostate cancer tumor progression
Journal
Molecular and cellular biochemistry
Fusing a TurboID tag with the Andrias davidianus ranavirus 2L reduced virus adsorption efficiency
Journal
Microbial pathogenesis
Alterations in the expression level of visfatin in the lungs of piglets infected with PRRSV and its effect on PRRSV replication
Journal
Microbial pathogenesis
Class Ⅰ histone deacetylase inhibitor regulate of Mycobacteria–Driven guanylate-binding protein 1 gene expression
Journal
Microbial pathogenesis
TurboID screening of ApxI toxin interactants identifies host proteins involved in Actinobacillus pleuropneumoniae-induced apoptosis of immortalized porcine alveolar macrophages - PMC
Journal
Veterinary research
Species
immortalized porcine alveolar macrophage (iPAM) cells
Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway
Journal
Cell stress & chaperones
Heat-labile enterotoxin enhances F4-producing enterotoxigenic E. coli adhesion to porcine intestinal epithelial cells by upregulating bacterial adhesins and STb enterotoxin - PMC
Journal
Veterinary research
Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function - PMC
Journal
Veterinary research
Diosmin ameliorates LPS-induced depression-like behaviors in mice: inhibition of inflammation and oxidative stress in the prefrontal cortex
Journal
Brain research bulletin
Zombie Cells, Composite Cells of Fungal-Human Keratinocytes of Plantar Hyperkeratosis-Like Lesions.
Study on the role and mechanism of β4GalT1 both in vivo and in vitro glioma
Journal
Eur Rev Med Pharmacol Sci
Surfactant protein D regulates murine testicular immune milieu and sperm functions
Journal
American Journal of Reproductive Immunology
SIPA1 promotes angiogenesis by regulating VEGF secretion in Müller cells through STAT3 activation - PMC
Species
Homo sapiens,Mus musculus
An exploration of the effect of Chinese herbal compound on the occurrence and development of large intestine cancer and intestinal flora - PMC
Comprehensive evaluation of cell death-related genes as novel diagnostic biomarkers for breast cancer - PMC
FOXG1 regulates the proliferation and apoptosis of human lung cancer cells - PMC
Proton pump inhibitors affect sperm parameters by regulating aquaporins - PMC
Knockdown of FUT11 inhibits the progression of gastric cancer via the PI3K/AKT pathway - PMC
Identification of the prognostic biomarkers and their correlations with immune infiltration in colorectal cancer through bioinformatics analysis and in vitro experiments - PMC
The NF-κB pathway plays a vital role in rat salivary gland atrophy model - PMC
Wuzi Yanzong Pill relieves CPZ-induced demyelination by improving the microenvironment in the brain - PMC
Isolation, characterization and anti-UVB irradiation activity of an extracellular polysaccharide produced by Lacticaseibacillus rhamnosus VHPriobi O17 - PMC
Epithelium-derived miR-204 inhibits corneal neovascularization
Journal
Experimental Eye Research
A Priori Activation of Apoptosis Pathways of Tumor (AAAPT) technology: Development of targeted apoptosis initiators for cancer treatment
Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites
Species
Saccharomyces cerevisiae
Molecular Characterization and Functional Analysis of a Putative Octopamine/Tyramine Receptor during the Developmental Stages of the Pacific Oyster, Crassostrea gigas
2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction - PMC
GSK-3 inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation - PMC
Exosomal miR-133a-3p promotes the growth and metastasis of lung cancer cells following incomplete microwave ablation
Journal
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Effects of electroacupuncture on the expression of hypothalamic neuropeptide Y and ghrelin in pubertal rats with polycystic ovary syndrome - PMC
SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury
Journal
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells
Journal
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Fucoxanthin triggers ferroptosis in glioblastoma cells by stabilizing the transferrin receptor
Journal
Medical oncology (Northwood, London, England)
Species
Homo sapiens, Mus musculus
SETD2 controls m6A modification of transcriptome and regulates the molecular oncogenesis of glioma
Journal
Medical oncology (Northwood, London, England)
Preparation, characterization and pharmacodynamic study on deep second degree burns of total flavonoids composite phospholipids liposome of Oxytropis falcata Bunge
Journal
Drug Dev Ind Pharm
Platonin Protects Against Cerebral Ischemia/Reperfusion Injury in Rats by Inhibiting NLRP3 Inflammasomes via BNIP3/LC3 Signaling Mediated Autophagy
Physical and social environmental enrichment alleviate ferroptosis and inflammation with inhibition of TLR4/MyD88/p38MAPK pathway in chronic cerebral
Journal
Brain research bulletin
Deletion of Arrb2 down-regulates autophagy in the mouse hippocampus via Akt-mTOR pathway activation
Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury in rats through SIRT1 activation
OsCSN1 Regulates the Growth and Development of Rice Seedlings through the Degradation of SLR1 in the GA Signaling Pathway
Journal
Journal of plant physiology
Bortezomib inhibits hepatocellular carcinoma via the Hippo‐YAP signaling pathway
Journal
Basic & clinical pharmacology & toxicology
CFAP61 knockdown aggravates male infertility by inhibiting testosterone secretion by Leydig cells via the MAPK/COX-2 pathway
Journal
Functional & integrative genomics
Comprehensive Analysis of Prognosis and Immune Function of CD70-CD27 Signaling Axis in Pan-Cancer
Journal
Functional & integrative genomics
Deciphering the RNA-binding protein interaction with the mRNAs encoded from human chromosome 15q11. 2 BP1-BP2 microdeletion region
Journal
Functional & integrative genomics
Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice.
Journal
BMC complementary and alternative medicine
Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1-42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal neurodevelopment processes
Journal
Metabolic brain disease
Emodin induced necroptosis in the glioma cell line U251 via the TNF-/RIP1/RIP3 pathway.
Journal
Investigational new drugs
Species
Homo sapiens, Mus musculus
SiO2 dust induces inflammation and pulmonary fibrosis in rat lungs through activation of ASMase/Ceramide pathway
Journal
Journal of applied toxicology : JAT
Acute Chemogenetic Activation of CamKIIα-Positive Forebrain Excitatory Neurons Regulates Anxiety-Like Behaviour in Mice.
Journal
Frontiers in Behavioral Neuroscience
Identification of core genes associated with type 2 diabetes mellitus and gastric cancer by bioinformatics analysis
Journal
Annals of translational medicine
FNDC5 overexpression promotes the survival rate of bone marrow mesenchymal stem cells after transplantation in a rat cerebral infarction model
Journal
Annals of translational medicine
Wogonin reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12-CXCR4/7 axis in bone marrow microenvironment
miR-126-3p contributes to sorafenib resistance in hepatocellular carcinoma via downregulating SPRED1
Mitochondria-specific peptide amphiphiles induce mitochondrial dysfunction and peripheral T-cell lymphomas (PTCL) damage - PMC
Journal
Annals of translational medicine
MiR-495 regulates cellular ROS levels by targeting sod2 to inhibit intracellular survival of Mycobacterium tuberculosis in macrophages
Antibodies Specific to Membrane Proteins Are Effective in Complement-Mediated Killing of Mycoplasma bovis
Journal
Infection and Immunity
Species
Oryctolagus cuniculus
Functional characterization of a putative Tumor Necrosis Factor Superfamily Member 10 in blood clam (Tegillarca granosa)
Species
Tegillarca granosa
A GTP-dependent Phosphoenolpyruvate Carboxykinase from Crassostrea gigas Involved in Immune Recognition
Journal
Developmental and comparative immunology
The hematopoiesis in gill and its role in the immune response of Pacific oyster Crassostrea gigas against secondary challenge with Vibrio splendidus
Journal
Developmental and comparative immunology
CpG ODNs induced autophagy via reactive oxygen species (ROS) in Chinese mitten crab, Eriocheir sinensis
Journal
Developmental And Comparative Immunology
Hemolymph C1qDC promotes the phagocytosis of oyster Crassostrea gigas hemocytes by interacting with the membrane receptor β-integrin.
Journal
Developmental and comparative immunology
Species
Mus musculus,Rattus norvegicus,Oyster
A vital ubiquitin-conjugating enzyme CgUbe2g1 participated in regulation of immune response of Pacific oyster Crassostrea gigas.
Journal
Developmental and comparative immunology
Targeting PIK3CG in Combination with Paclitaxel as a Potential Therapeutic Regimen in Claudin-Low Breast Cancer
Journal
Cancer Management and Research
Inhibition of Fatty Acid β-Oxidation by Fatty Acid Binding Protein 4 Induces Ferroptosis in HK2 Cells Under High Glucose Conditions - PMC
Journal
Endocrinology and metabolism (Seoul, Korea)
The DUF1943 and VWD domains endow Vitellogenin from Crassostrea gigas with the agglutination and inhibition ability to microorganism
Journal
Developmental and comparative immunology
Spindle‐E is essential for gametogenesis in the silkworm, Bombyx mori
Species
Bombyx mori Linnaeus
Identification and characterization of a tumor necrosis factor receptor like protein encoded by Cyprinid Herpesvirus 2
Journal
Developmental and comparative immunology
Species
Carassius auratus gibelio
The modulation of extracellular superoxide dismutase in the specifically enhanced cellular immune response against secondary challenge of Vibrio splendidus in Pacific oyster (Crassostrea gigas)
Journal
Developmental and comparative immunology
Application
PAMPs binding assa
Comparative study of three C1q domain containing proteins from pacific oyster Crassostrea gigas
Journal
Developmental and comparative immunology
Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells via inhibition of heat shock protein 27 phosphorylation - PMC
Exogenous Spermidine Alleviates Diabetic Myocardial Fibrosis Via Suppressing Inflammation and Pyroptosis in db/db Mice - PMC
Journal
Balkan medical journal
Rutin restrains the growth and metastasis of mouse breast cancer cells by regulating the microRNA‐129‐1‐3p‐mediated calcium signaling pathway
Journal
Journal of biochemical and molecular toxicology
Emodin suppresses oxaliplatininduced neuropathic pain by inhibiting COX2/NFB mediated spinal inflammation
Journal
Journal of biochemical and molecular toxicology
microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis
Ndufa6 regulates adipogenic differentiation via Scd1
Osteogenic microenvironment affects palatal development through glycolysis
Journal
Differentiation; research in biological diversity
Immunization with a recombinant fusion of porcine reproductive and respiratory syndrome virus modified GP5 and ferritin elicits enhanced protective immunity in pigs
Nuclear transporter karyopherin subunit alpha 3 levels modulate Porcine circovirus type 2 replication in PK-15 cells
Fusion of pseudorabies virus glycoproteins to IgG Fc enhances protective immunity against pseudorabies virus.
2-Bromopalmitate attenuates inflammatory pain by maintaining mitochondrial fission/fusion balance and function
Journal
Acta biochimica et biophysica Sinica
PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation
Journal
Acta Biochim Biophys Sin (Shanghai)
Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPARγ expression - PMC
Journal
Acta biochimica et biophysica Sinica
Species
Mus musculus,Rattus norvegicus
miR-425-5p Regulates Proliferation of Bovine Mammary Epithelial Cells by Targeting TOB2 - PMC
CPEB1, a novel risk gene in recent-onset schizophrenia, contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1
Journal
World J Psychiatry
A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions - PMC
Journal
Channels (Austin, Tex.)
Species
Oryctolagus cuniculus
VasH contributes to virulence of Aeromonas hydrophila and is necessary to the T6SS-mediated bactericidal effect
Journal
Frontiers in veterinary science
Species
Ctenopharyngodon idellus
Stearic acid induces CCK and GLP-1 upregulation via GPR120/PLC-β, leading to reduced appetite in Hu sheep fed with rice straw - PMC
Journal
Frontiers in veterinary science
Caffeic Acid Phenethyl Ester (CAPE) Improves Boar Sperm Quality and Antioxidant Capacity in Liquid Preservation (17°C) Linked to AMPK Activity Maintenance - PMC
Journal
Frontiers in veterinary science
GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell Serotonin Absorptive Capacity
Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes
Journal
Bioorganic & Medicinal Chemistry
miR-657 Targets SRCIN1 via the Slug Pathway to Promote NSCLC Tumor Growth and EMT Induction - PMC
MicroRNA-1291 promotes endometrial fibrosis by regulating the ArhGAP29-RhoA/ROCK1 signaling pathway in a murine model
Journal
Molecular medicine reports
Species
Homo sapiens, Mus musculus
Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke
Journal
Molecular medicine reports
Investigation of the expressions of MMPs and TIMPs between isogeneic and allogeneic rat aortic transplantation
Journal
Molecular medicine reports
Effects of Txk‑mediated activation of NF‑κB signaling pathway on neurological deficit and oxidative stress after ischemia‑reperfusion in rats
Urantide prevents CCl4‑induced acute liver injury in rats by regulating the MAPK signalling pathway
Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway
Corilagin induces apoptosis and autophagy in NRF2‑addicted U251 glioma cell line
MicroRNA‑138‑5p drives the progression of heart failure via inhibiting sirtuin 1 signaling
Bone marrow stem cells therapy alleviates vascular injury in a chronic obstructive pulmonary disease‑obstructive sleep apnea overlap syndrome rat model
Journal
Molecular Medicine Reports
Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo.
Journal
Molecular Medicine Reports
Effects of bone marrow‑derived mesenchymal stem cell transplantation on chronic obstructive pulmonary disease/obstructive sleep apnea overlap syndrome in rats
Journal
Molecular medicine reports
miR‑329‑3p regulates neural stem cell proliferation by targeting E2F1.
Journal
Molecular medicine reports
FAK regulates epithelial‑mesenchymal transition in adenomyosis.
Journal
Molecular medicine reports
Overexpression of Wilms' tumor 1 in skin lesions of psoriasis is associated with abnormal proliferation and apoptosis of keratinocytes
Journal
Molecular medicine reports
Concurrent administration of thyroxine and donepezil induces plastic changes in the prefrontal cortex of adult hypothyroid rats
Journal
Molecular medicine reports
Collagenbinding vascular endothelial growth factor (CBDVEGF) promotes liver regeneration in murine partial hepatectomy
Journal
Molecular medicine reports
Expression and significance of histone methyltransferase SET domain containing 2 with histone H3 lysine 36 trimethylation in mouse hepatic oval cells differentiated into bile duct epithelial cells in vitro - PMC
Journal
Molecular medicine reports
E2F1 promotes Warburg effect and cancer progression via upregulating ENO2 expression in Ewing sarcoma
Journal
Molecular medicine reports
Species
Oryctolagus cuniculus
miR-613 inhibits the proliferation of human ovarian granulosa cells by arresting cell cycle progression via the targeting of IGF-1
Journal
Molecular medicine reports
MicroRNA-133b Inhibits nTumor Cell Proliferation, Migration and Invasion by Targeting SUMO1 in Endometrial Carcinoma
Journal
Technol Cancer Res Treat
ATP5A1 Participates in Transcriptional and Posttranscriptional Regulation of Cancer-Associated Genes by Modulating Their Expression and Alternative Splicing Profiles in HeLa Cells
Journal
Technol Cancer Res Treat
Influence of Autophagy Inhibition on Lung Adenocarcinoma Cell Migration and Invasion Ability, and Efficacy of Gefitinib
Journal
Technol Cancer Res Treat
B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo
Journal
Technol Cancer Res Treat
The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma
Journal
technol cancer res treat
Long Non-Coding RNA PVT1 Regulates the Resistance of the Breast Cancer Cell Line MDA-MB-231 to Doxorubicin via Nrf2
Journal
Technol Cancer Res Treat
Emodin Alleviates Arthritis Pain through Reducing Spinal Inflammation and Oxidative Stress
Xanthohumol relieves arthritis pain in mice by suppressing mitochondrial-mediated inflammation - PMC
Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion.
Journal
Journal of Assisted Reproduction and Genetics
Human cytomegalovirus IE2 may impair the cognitive ability of the hippocampus through the GluNRs/CaMKIIα/CREB signaling pathway in the Rosa26-LSL-IE2/Cre mouse
Hypoglycemia causes dysregulation of Neuregulin 1, ErbB receptors, Ki67 in cerebellum and brainstem during diabetes: Implications in motor function.
Journal
Behavioural brain research
Effects of chronic mild stress induced depression on synaptic plasticity in mouse hippocampus.
Journal
Behavioural brain research
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury
Journal
Behavioural Brain Research
Therapeutic Effects of Melatonin in Female Mice with Central Precocious Puberty by Regulating the Hypothalamic Kiss-1/Kiss1R System
Journal
Behavioural brain research
MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats
Journal
Behavioural brain research
Role of pyroglutamic acid in cumulus cells of women with polycystic ovary syndrome
Journal
Journal of assisted reproduction and genetics
Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy - PMC
Exogenous Melatonin Regulates Puberty and the Hypothalamic GnRH-GnIH System in Female Mice - PMC
MiR-1207-5p targets PYCR1 to inhibit the progression of prostate cancer
Journal
Biochemical and biophysical research communications
The microgravity induces the ciliary shortening and an increased ratio of anterograde/retrograde intraflagellar transport of osteocytes
Journal
Biochem Biophys Res Commun
Guanine nucleotide exchange factor RABGEF1 facilitates TNF-induced necroptosis by targeting cIAP1
Journal
Biochemical and biophysical research communications
Characterization of a silkworm UFM1 homolog in regulating Bombyx mori unfolded protein response and nucleopolyhedrovirus replication
Journal
Biochemical and biophysical research communications
Species
Bombyx mori Linnaeus
RGS16 regulates Hippo-YAP activity to promote esophageal cancer cell proliferation and migration
Journal
Biochemical and biophysical research communications
Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSC-EXO) regulate autophagy through AMPK-ULK1 signaling pathway to ameliorate …
Journal
Biochemical and biophysical research communications
FOXA2 promotes esophageal cancer migration and metastasis by activating CXCR4 expression
Journal
Biochemical and biophysical research communications
Inhibition of microRNA-448 suppresses CD4+ T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus
Journal
Biochemical and biophysical research communications
Downregulation of oncogenic gene TGFR2 by miRNA-107 suppresses non-small cell lung cancer
Journal
Pathology, Research and Practice
Knockdown of long non-coding RNA TINCR decreases radioresistance in colorectal cancer cells
Journal
Pathology, research and practice
PM2.5 activated NLRP3 inflammasome and IL-1β release in MH-S cells byfacilitating autophagy via activating Wnt5a - PMC
Journal
International journal of immunopathology and pharmacology
ZIP12 Contributes to Hypoxic Pulmonary Hypertension by Driving Phenotypic Switching of Pulmonary Artery Smooth Muscle Cells
Journal
Journal of cardiovascular pharmacology
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas
Inhibiting MAPK14 showed anti-prolactinomas effect
Cudraflavone B induces human glioblastoma cells apoptosis via ER stress-induced autophagy - PMC
Transmembrane p24 trafficking protein 2 regulates inflammation through the TLR4/NF-κB signaling pathway in lung adenocarcinoma
Journal
World journal of surgical oncology
Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways
Journal
General and comparative endocrinology
Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma - PMC
Journal
World journal of surgical oncology
Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Ischemia-Reperfusion Injury and Promote Survival of Skin Flaps in Rats - PMC
Journal
Life (Basel, Switzerland)
Shp2 expression is upregulated in cervical cancer, and Shp2 contributes to cell growth and migration and reduces sensitivity to cisplatin in cervical cancer cells.
Journal
Pathology, research and practice
Diosgenin inhibits the proliferation of gastric cancer cells via inducing mesoderm posterior 1 down-regulation-mediated alternative reading frame expression
HSP90 inhibitors 17-AAG and VER-82576 inhibit porcine deltacoronavirus replication in vitro
Next-generation sequencing sheds light on the interaction between virus and cell during foot-and-mouth disease virus persistent infection
Effect of the Abnormal Expression of BMP-4 in the Blood of Diabetic Patients on the Osteogenic Differentiation Potential of Alveolar BMSCs and the Rescue Effect of Metformin: A Bioinformatics-Based Study
Ginsenoside Rg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma
Journal
BioMed Research International
O-acetyl-homoserine sulfhydrylase deficient Streptococcus suis serotype 2 strain SC19 becomes an avirulent strain and provides immune protection against
Journal
Veterinary microbiology
Overexpression of angiotensin-converting enzyme 2 contributes to the amelioration of Streptococcus uberis-induced inflammatory injury in mammary epithelial cells
Journal
Veterinary microbiology
CD4 is an important Host Factor for Japanese Encephalitis Virus Entry and Replication in PK-15 Cells
Journal
Veterinary microbiology
A self-assembled nanoparticle vaccine based on pseudorabies virus glycoprotein D induces potent protective immunity against pseudorabies virus infection
Journal
Veterinary microbiology
Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways
Journal
Veterinary microbiology
Species
Chlorocebus aethiops
Resveratrol Improves the Frozen-Thawed Ram Sperm Quality - PMC
Journal
Animals : an open access journal from MDPI
Mild Intermittent Cold Stimulation Affects Cardiac Substance Metabolism via the Neuroendocrine Pathway in Broilers - PMC
Journal
Animals : an open access journal from MDPI
Species
Oryctolagus cuniculus
Intermittent and Mild Cold Stimulation Maintains Immune Function Stability through Increasing the Levels of Intestinal Barrier Genes of Broilers - PMC
Journal
Animals : an open access journal from MDPI
Microcyst fluid promotes the migration and invasion of fibroblasts in the adventitial layer of alveolar echinococcosis
Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-B/NLRP3 signaling pathway in vivo and in vitro - PMC
Journal
Food & nutrition research
TPI1 promotes MAPK/ERKinduced EMT, cell migration and invasion in lung adenocarcinoma
Gardenia jasminoides J. Ellis extract GJ-4 attenuates hyperlipidemic vascular dementia in rats via regulating PPAR-γ-mediated microglial polarization - PMC
Journal
Food & nutrition research
Immunoproteasome is up-regulated in rotenone-induced Parkinson's disease rat model
Microencapsulated Schwann Cell Transplantation Inhibits P2X2/3 Receptors Overexpression in a Sciatic Nerve Injury Rat Model with Neuropathic Pain
Journal
Neuroscience Letters
Autophagy inhibition mediated by trillin promotes apoptosis in hepatocellular carcinoma cells via activation of mTOR/STAT3 signaling
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Analysis of the m6A modification regulators in the substantia nigra and striatum of MPTP-induced Parkinson's disease mice
Journal
Neuroscience letters
Astragalin, (3-O-glucoside of kaempferol), isolated from Moringa oleifera leaves modulates leptin, adiponectin secretion and inhibits adipogenesis in 3T3-L1 adipocytes
Journal
Archives of physiology and biochemistry
Identification of an LDLR variant in a Chinese familial hypercholesterolemia and its relation to ROS/NLRP3-Mediated pyroptosis in hepatic cells - PMC
Journal
Journal of geriatric cardiology : JGC
The opening of mitochondrial permeability transition pore (mPTP) and the inhibition of electron transfer chain (ETC) induce mitophagy in wheat roots under …
BmAbl1 Regulates Silk Protein Synthesis via Glutathione Metabolism in Bombyx mori - PMC
Species
Bombyx mori Linnaeus
Hsa_circ_0000285 contributes to gastric cancer progression by upregulating FN1 through the inhibition of miR-1278
Journal
Journal of clinical laboratory analysis
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Integrated bioinformatics analyses of key genes involved in hepatocellular carcinoma immunosuppression
MicroRNA-100 inhibits breast cancer cell proliferation, invasion and migration by targeting FOXA1
MicroRNA-27b-3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP-13
Novel AXL-targeted agents overcome FLT3 inhibitor resistance in FLT3-ITD + acute myeloid leukemia cells
SOCS2 is a potential prognostic marker that suppresses the viability of hepatocellular carcinoma cells
Long non-coding RNA MIR22HG inhibits glioma progression by downregulating microRNA-9/CPEB3
T cell immune regulator 1 is a prognostic marker associated with immune infiltration in glioblastoma multiforme
Evodiamine induces reactive oxygen species‑dependent apoptosis and necroptosis in human melanoma A‑375 cells
Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells via the PI3K/Akt/ERK signaling pathway
Decreased expression of TXNIP is associated with poor prognosis and immune infiltration in kidney renal clear cell carcinoma - PMC
Astragaloside IV Inhibits NLRP3 Inflammasome-Mediated Pyroptosis via Activation of Nrf-2/HO-1 Signaling Pathway and Protects against Doxorubicin
Journal
Frontiers in bioscience (Landmark edition)
miR-5590-3p inhibits the proliferation and metastasis of renal cancer cells by targeting ROCK2 to inhibit proliferation, migration and invasion - PMC
Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo
Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney
Journal
Kidney & Blood Pressure Research
Protective effect of Bifidobacterium animalis CGMCC25262 on HaCaT keratinocytes
Journal
International microbiology : the official journal of the Spanish Society for Microbiology
Gene Variants in Two Families with Inherited Coagulation Factor Ⅺ Deficiency and Identification of Mutations
Journal
Acta haematologica
Flotillin-1 promotes EMT of gastric cancer via stabilizing Snail - PMC
Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6
CYT387 Inhibits the Hyperproliferative Potential of Fibroblast-like Synoviocytes via Modulation of IL-6/JAK1/STAT3 Signaling in Rheumatoid Arthritis
All-Trans Retinoic Acid Promotes M2 Macrophage Polarization in Vitro by Activating the p38MAPK/STAT6 Signaling Pathway
Journal
Immunological investigations
Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1induced intestinal inflammatory injury
Journal
Toxicon : official journal of the International Society on Toxinology
11C-Labeled Pictilisib (GDC-0941) as a Molecular Tracer Targeting Phosphatidylinositol 3-Kinase (PI3K) for Breast Cancer Imaging
Journal
Contrast Media & Molecular Imaging,
Ru360 Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Inhibiting MCU-Mediated Mitochondrial Dysfunction - PMC
Journal
Neuropsychiatric disease and treatment
TNF-α level affects etanercept clearance: TNF-α concentration as a new correction factor of allometric scaling to predict individual etanercept clearances in patients with ankylosing spondylitis
Journal
Clinical and experimental pharmacology & physiology
Echinacoside Protects Against Dysfunction of Spermatogenesis Through the MAPK Signaling Pathway
Expression of Cannabinoid Receptors in Myometrium and its Correlation With Dysmenorrhea in Adenomyosis.
Journal
Reproductive sciences
Dietary alpha-lipoic acid supplementation improves spermatogenesis and semen quality via antioxidant and anti-apoptotic effects in aged breeder roosters
MiR-183 impeded embryo implantation by regulating Hbegf and Lamc1 in mouse uterus
Efficient co-expression of multiple enzymes from a single promoter mediated by virus 2A sequence in the oleaginous yeast Rhodosporidium toruloides
Journal
FEMS yeast research
Autophagic and apoptotic proteins in goat corpus luteum and the effect of Adiponectin/AdipoRon on luteal cell autophagy and apoptosis
ZnSO4 Protects against premature ovarian failure through PI3K/AKT/GSK3β signaling pathway
Dual role of NR4A1 in porcine ovarian granulosa cell differentiation and granulosa-lutein cell regression in vitro
Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis
Journal
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas
Sulforaphane kills Mycobacterium tuberculosis H37Ra and Mycobacterium smegmatis mc2155 through a reactive oxygen species dependent mechanism
Journal
Journal of microbiology (Seoul, Korea)
Azeliragon ameliorates Alzheimer's disease via the Janus tyrosine kinase and signal transducer and activator of transcription signaling pathway
Journal
Clinics (Sao Paulo)
Thymoquinone mitigates obesity and diabetic parameters through regulation of major adipokines, key lipid metabolizing enzymes and AMPK/p-AMPK in diet-induced
FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of Colorectal Cancer - PMC
Journal
Technology in cancer research & treatment
Periodic Variation of AAK1 in an Aβ1-42-Induced Mouse Model of Alzheimer's Disease.
Journal
Journal of Molecular Neuroscience : MN
Mechanism underlying the effect of Pulsatilla decoction in hepatocellular carcinoma treatment: a network pharmacology and in vitro analysis - PMC
Journal
BMC complementary medicine and therapies
SIRT3 inhibition suppresses hypoxia‐inducible factor 1α signaling and alleviates hypoxia‐induced apoptosis of type B spermatogonia GC‐2 cells
Genome Wide Differential Expression Profiles in Nevus Sebaceous Uncovered Low Expression of CDKN2AIP and Construction of a ceRNA Network
Journal
Clinical, cosmetic and investigational dermatology
miR-34a regulates adipogenesis in porcine intramuscular adipocytes by targeting ACSL4
Identification of potential key genes and functional role of CENPF in osteosarcoma using bioinformatics and experimental analysis
Comparison of the differentiation abilities of bone marrow?derived mesenchymal stem cells and adipose?derived mesenchymal stem cells toward nucleus pulposus-like cells in three?dimensional culture
Inhibition of autophagy promotes human RSV NS1?induced inflammation and apoptosis in vitro
High glucose induces HSP47 expression and promotes the secretion of inflammatory factors through the IRE1α/XBP1/HIF?1α pathway in retinal Müller cells
Ozone induces tolerance against cardiomyocytes oxygen?glucose deprivation/reperfusion through inhibition of autophagy pathway
Role of miRNAs and lncRNAs in dexamethasone-induced myotube atrophy in vitro
Long non-coding RNA ADAMTS9-AS2 inhibits liver cancer cell proliferation, migration and invasion
Schisandrin B exerts hypnotic effects in PCPA‑treated rats by increasing hypothalamic 5‑HT and γ‑aminobutyric acid levels
EZH2 regulates sFRP4 expression without affecting the methylation of sFRP4 promoter DNA in colorectal cancer cell lines
Elevated estrogen receptor β expression in triple negative breast cancer cells is associated with sensitivity to doxorubicin by inhibiting the PI3K/AKT/mTOR signaling pathway
Downregulation of DEC1 by RNA interference attenuates ischemia/reperfusion-induced myocardial inflammation by inhibiting the TLR4/NF-κB signaling pathway
Journal
Experimental and Therapeutic Medicine
Clinical and pathological characteristics of IgG4-related interstitial lung disease.
Journal
Experimental and Therapeutic Medicine
Ophiopogonin D attenuates PM2. 5‑induced inflammation via suppressing the AMPK/NF‑κB pathway in mouse pulmonary epithelial cells
Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice
Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain-1 expression and inhibits NF-κB activation in streptozotocin-induced diabetic rats.
Journal
Experimental and therapeutic medicine
PP2Ac knockdown attenuates lipotoxicity-induced pancreatic -cell dysfunction and apoptosis - PMC
Journal
Experimental and therapeutic medicine
Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice - PMC
Journal
Experimental and therapeutic medicine
Growth restriction and congenital heart disease caused by a novel TAB2 mutation: A case report - PMC
Journal
Experimental and therapeutic medicine
Alleviating effect of lycorine on CFA-induced arthritic pain via inhibition of spinal inflammation and oxidative stress - PMC
Journal
Experimental and therapeutic medicine
Resveratrol ameliorates oxaliplatin-induced neuropathic pain via anti-inflammatory effects in rats - PMC
Journal
Experimental and therapeutic medicine
Investigation of SRP9 protein expression in breast cancer
PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors.
Journal
Molecular biology reports
Vasorin contributes to lung injury via FABP4-mediated inflammation
Journal
Molecular biology reports
Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin
Journal
Molecular biology reports
A circular RNA from NFIX facilitates oxidative stress-induced H9c2 cells apoptosis
Journal
In Vitro Cell Dev Biol Anim
Myricetin ameliorates the IL-21-induced tumorigenic phenotype of adjuvant-induced arthritis FLS by modulating the choline kinase signaling cascade
Journal
In vitro cellular & developmental biology. Animal
Clock genes are expressed in cementum and regulate the proliferation and mineralization of cementoblasts
Journal
In vitro cellular & developmental biology. Animal
Effects of medical chitosan on capsular formation following silicone implant insertion in a rabbit model
Journal
Aesthetic plastic surgery
Species
Oryctolagus cuniculus
The Toll-like receptor ligand, CpG oligodeoxynucleotides, regulate proliferation and osteogenic differentiation of osteoblast
Combination effect of Chinese kidney-tonifying granules and platelet-rich plasma gels on enhancing bone healing in rat models with femur defects - PMC
Journal
Journal of orthopaedic surgery and research
The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion - PMC
Journal
Journal of orthopaedic surgery and research
Effects of Changyu Daotan Decoction on Depression via Restoration of Mice Hippocampus and Alteration of Expression of Relevant Neurotrophic Factors - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Curcumin Analog, HO-3867, Induces Both Apoptosis and Ferroptosis via Multiple Mechanisms in NSCLC Cells with Wild-Type p53 - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Species
Oryctolagus cuniculus
Isoschaftoside Inhibits Lipopolysaccharide-Induced Inflammation in Microglia through Regulation of HIF-1α-Mediated Metabolic Reprogramming - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Effects and Action Mechanism of Huoxue Tongluo Formula on the Formation of Neutrophil Extracellular Traps - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
miR-214-3p Protects and Restores the Myocardial Tissue of Rat Myocardial Infarction Model by Targeting PTEN - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Influence of Ginsenoside Rh2 on Cardiomyocyte Pyroptosis in Rats with Acute Myocardial Infarction - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells
Journal
Evidence-based complementary and alternative medicine : eCAM
The clinical significance, prognostic value and biological role of lncRNA LINC01793 in oral squamous cell carcinoma
Mechanism Study on Radiosensitization Effect of Curcumin in Bladder Cancer Cells Regulated by Filamin A
Journal
Dose-response : a publication of International Hormesis Society
A trypsin inhibitor-like protein secreted by Cotesia vestalis teratocytes inhibits hemolymph prophenoloxidase activation of Plutella xylostella.
Journal
Journal of insect physiology
Species
Plutella xylostella
Elevated plasma CaM expression in patients with acute cerebral infarction predicts poor outcomes and is inversely associated with miR-26b expression
Journal
International journal of neuroscience
Comparative analysis of mouse embryonic palatal mesenchymal cells isolated by two primary culture methods
CCL26 silence represses colon cancer by inhibiting the EMT signaling pathway
Nec-1 alleviated the deleterious effect of CoCl2 on C2C12 myoblast differentiation and fusion via the mTOR pathway
The relationship between abnormal Core binding factor-β expression in human cartilage and osteoarthritis
Journal
BMC Musculoskelet Disord
Downregulation of AMPK dependent FOXO3 and TFEB involves in the inhibition of autophagy in diabetic cataract
Inhibitory effects of Lactobacillus plantarum metabolites on porcine epidemic diarrhea virus replication
Journal
Research in veterinary science
Species
Chlorocebus aethiops
Manganese deficiency induces avian tibial dyschondroplasia by inhibiting chondrocyte proliferation and differentiation
Combination of HGF and IGF-1 promotes connexin 43 expression and improves ventricular arrhythmia after myocardial infarction through activating the MAPK/ERK and MAPK/p38 signaling pathways in a rat model.
Journal
Cardiovascular diagnosis and therapy
The SNHG1-Centered ceRNA Network Regulates Cell Cycle and Is a Potential Prognostic Biomarker for Hepatocellular Carcinoma
Journal
The Tohoku journal of experimental medicine
Expression profile and localization of vitellogenin mRNA and protein during ovarian development in turbot (Scophthalmus maximus).
Journal
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
Species
Scophthalmus maximus
Mechanism of Rhodiola rosea-Euonymus alatus drug pair against rheumatoid arthritis: Network pharmacology and experimental validation - PMC
Journal
Immunity, inflammation and disease
Protective effect of isoliquiritigenin in amiodarone-induced damage of human umbilical vein endothelial cells - PMC
Journal
Immunity, inflammation and disease
Naringenin ameliorates collagen-induced arthritis through activating AMPK-mediated autophagy in macrophages - PMC
Journal
Immunity, inflammation and disease
Inducible nitric oxide synthase regulates macrophage polarization via the MAPK signals in concanavalin A-induced hepatitis - PMC
Journal
Immunity, inflammation and disease
Preparation of Vitamin E-Containing High-Density Lipoprotein and Its Protective Efficacy on Macrophages
Journal
Assay and Drug Development Technologies
Ticagrelor prevents tumor metastasis via inhibiting cell proliferation and promoting platelet apoptosis
The role of emodin on cisplatin resistance reversal of lung adenocarcinoma A549/DDP cell
Schisandrin B attenuates bleomycin-induced pulmonary fibrosis in mice through the wingless/integrase-1 signaling pathway
Journal
Experimental lung research
miR-181c, a potential mediator for acute kidney injury in a burn rat model with following sepsis
Journal
European journal of trauma and emergency surgery : official publication of the European Trauma Society
Scutellarin ameliorates diabetic nephropathy via TGF-1 signaling pathway
Journal
Biological & pharmaceutical bulletin
Calcitriol attenuates vascular remodeling in association with alteration of ppET-1/ETBR/eNOS and ETAR expression in acute and chronic phases of kidney ischemia …
Journal
Canadian journal of physiology and pharmacology
Based on proteomics to explore the mechanism of mecobalamin promoting the repair of injured peripheral nerves
Journal
Canadian journal of physiology and pharmacology
Mitochondrial dysfunction in follicles is associated with broodiness in Zhedong white goose
Journal
Animal reproduction science
MiR-5189-3p Suppresses cell Proliferation, Invasion and Migration Through Targeting EIF5A2 in Laryngeal Squamous Cell Carcinoma
Journal
Biochemical genetics
Analysis of cyclooxygenase 2, programmed cell death ligand 1, and arginase 1 expression in human pituitary adenoma
Journal
World neurosurgery
Death-Associated Protein Kinase 1 Regulates Oxidative Stress in Cardiac Ischemia Reperfusion Injury
Journal
Cells, tissues, organs
Co-infection with porcine bocavirus and porcine circovirus 2 affects inflammatory cytokine production and tight junctions of IPEC-J2 cells.
Alleviative effects of foraging exercise on depressive-like behaviors in chronic mild stress-induced ischemic rat model
Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells
Endoplasmic reticulum stress mediates osteocyte death under oxygen-glucose deprivation in vitro
Identification of ADAM23 as a Potential Signature for Psoriasis Using Integrative Machine-Learning and Experimental Verification - PMC
Journal
International journal of general medicine
CircRRAS2 promotes myogenic differentiation of bovine MuSCs and is a novel regulatory molecule of muscle development
Journal
Animal biotechnology
MYH1F promotes the proliferation and differentiation of chicken skeletal muscle satellite cells into myotubes
Journal
Animal biotechnology
The Mammalian Target of Rapamycin–70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma
Journal
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
Protective Effect of Salidroside on Mitochondrial Disturbances via Reducing Mitophagy and Preserving Mitochondrial Morphology in OGD-induced Neuronal Injury
Journal
Current medical science
Mitochondrial gene expression analysis reveals aberrant transcription of cox3 in Gossypium barbadense CMS line H276A
Journal
Development genes and evolution
LINC00974 sponges miR-33a to facilitate cell proliferation, invasion, and EMT of ovarian cancer through HMGB2 upregulation
Journal
Genetics and molecular biology
Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system
Journal
Nutrition research and practice
CD36-and obesity-associated granulosa cells dysfunction
Journal
Reproduction, fertility, and development
Long noncoding RNA H19 accelerates tenogenic differentiation by modulating miR-140-5p/VEGFA signaling
MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway - PMC
Journal
European journal of histochemistry : EJH
Clostridium butyricum CB1 up-regulates FcRn expression via activation of TLR2/4-NF-κB signaling pathway in porcine small intestinal cells
Journal
Vet Immunol Immunopathol
The related mechanism of complete Freund's adjuvant‐induced chronic inflammation pain based on metabolomics analysis
Journal
Biomedical chromatography : BMC
Biochanin A in murine Schistosoma mansoni infection: effects on inflammation, oxidative stress and fibrosis
Journal
Journal of helminthology
Role of serum CAP1 protein in the diagnosis of patients with first-time acute myocardial infarction - PMC
SIRT3 confers protection against acute pulmonary embolism by anti-inflammation, anti-oxidative stress, anti-apoptosis: participation of AMPK/mTOR pathway
Journal
Experimental animals
Ferroptosis involved in sevoflurane-aggravated young rats brain injury induced by liver transplantation - PMC
The Temporal and Spatial Changes of Th17, Tregs, and Related Cytokines in Epilepsy Lesions
Journal
Applied bionics and biomechanics
Selenium-enriched Polysaccharides from Pyracantha fortuneana (SePFP) Ameliorated Hepatic Lipid Accumulation through Enhancing Mitochondrial Fatty Acid
Journal
Journal of oleo science
Effects of tacrolimus on autophagy protein LC3 in puromycin-damaged mouse podocytes
Evaluation of Allicin Against Alveolar Echinococcosis In Vitro and in a Mouse Model
Effects of serum starvation and vascular endothelial growth factor stimulation on the expression of Notch signalling pathway components
miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2
Journal
Open life sciences
Multiple roles of THY1 in gastric cancer based on data mining
Journal
Translational cancer research
RNA 5-Methylcytosine regulators are associated with cell adhesion and predict prognosis of endometrial cancer - PMC
Journal
Translational cancer research
In vitro study of piwi interaction RNA-31106 promoting breast carcinogenesis by regulating METTL3-mediated m6A RNA methylation - PMC
Journal
Translational cancer research
Engineered CBEs based on Macaca fascicularis A3A with improved properties for precise genome editing
Species
Macaca fascicularis
Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL - PMC
Journal
Cell death & disease
HSP90AB1 is a host factor that promotes Porcine deltacoronavirus replication
Journal
The Journal of biological chemistry
The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1
Journal
The Journal of biological chemistry
Interleukin-22 alleviates arginine-induced pancreatic acinar cell injury via the regulation of intracellular vesicle transport system: Evidence from proteomic analysis - PMC
Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
KRT17 From Keratinocytes With High Glucose Stimulation Inhibit Dermal Fibroblasts Migration Through Integrin 11 - PMC
Journal
Journal of the Endocrine Society
The miR-17 92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation
Application
WB, ELISA, RT-PCR
Perilipin2 inhibits the replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions - PMC
Journal
World journal of virology
TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy
Journal
The Journal of biological chemistry
Metabolomics Analysis Reveals Alterations in Cochlear Metabolic Profiling in Mice with Noise-Induced Hearing Loss
Journal
BioMed research international
Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication - PMC
Species
Homo sapiens, Chlorocebus aethiops
Histone Deacetylase9 Represents the Epigenetic Promotion of M1 Macrophage Polarization and Inflammatory Response via TLR4 Regulation - PMC
Journal
BioMed research international
Portulaca oleracea alleviates CCl4-induced acute liver injury by regulating hepatic S100A8 and S100A9
Journal
Chinese herbal medicines
Species
Homo sapiens, Mus musculus
Single-cell sequencing reveals the optimal time window for anti-inflammatory treatment in spinal cord injury
NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer
Application
WB, CO-IP, RT-PCR
Species
Homo sapiens, Mus musculus
Ginsenoside Rg3 Protects against Diabetic Cardiomyopathy and Promotes Adiponectin Signaling via Activation of PPAR- - PMC
The Functional Significance of McMafF_G_K in Molluscs: Implications for Nrf2-Mediated Oxidative Stress Response - PMC
Expression of a Mycoparasite Protease in Plant Petals Suppresses the Petal-Mediated Infection by Necrotrophic Pathogens
Species
Coniothyrium minitans
Persistent ER stress causes GPI anchor deficit to convert a GPI-anchored prion protein (PrP) into pro-PrP via the ATF6-miR449c-5p-PIGV axis
Journal
The Journal of biological chemistry
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-B signaling in keratinocyte - PMC
Journal
Cell death & disease
REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis - PMC
Journal
Cell death & disease
Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1 Branch of the Endoplasmic Reticulum Stress Response - PMC
Journal
Stem cells international
Topical Administration of an Apoptosis Inducer Mitigates Bleomycin-Induced Skin Fibrosis
Journal
ACS pharmacology & translational science
Application
Cellular Uptake and In Vitro Fibrotic Marker Visual-ization
Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis - PMC
Journal
Open medicine (Warsaw, Poland)
Ketogenic diet protects MPTP-induced mouse model of Parkinson's disease via altering gut microbiota and metabolites - PMC
Restoration of the Lost Human Beta Defensin (hBD-1) in Cancer as a Strategy to Improve the Efficacy of Chemotherapy
Journal
bioRxiv : the preprint server for biology
Protective effect of hydroxysafflor yellow A on MSCs against senescence induced by D-galactose
Journal
Chinese herbal medicines
Protective effect and mechanism insight of purified Antarctic kill phospholipids against mice ulcerative colitis combined with bioinformatics - PMC
Journal
Natural products and bioprospecting
The function of the phytoplasma effector SWP12 depends on the properties of two key amino acids
Journal
The Journal of biological chemistry
N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells - PMC
Journal
World journal of gastrointestinal oncology
Single-cell transcriptome reveals core cell populations and androgen-RXFP2 axis involved in deer antler full regeneration
Journal
Cell regeneration (London, England)
Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting - PMC
Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway - PMC
Journal
Cell death & disease
Cell Cycle-Related Gene SPC24: A Novel Potential Diagnostic and Prognostic Biomarker for Laryngeal Squamous Cell Cancer - PMC
Journal
BioMed research international
A protocol to characterize zebrafish LGP2 as a dual regulator of IFN response during viral infection - PMC
Vitamin D Protects against Traumatic Brain Injury via Modulating TLR4/MyD88/NF-κB Pathway-Mediated Microglial Polarization and Neuroinflammation - PMC
Journal
BioMed research international
Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats - PMC
Journal
Stem cells international
Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma
Journal
Discover. Oncology
Biogenic Selenium Nanoparticles Attenuate Aβ25–35-Induced Toxicity in PC12 Cells via Akt/CREB/BDNF Signaling Pathway
Multi-omics characterization of silent and productive HPV integration in cervical cancer
Species
Oryctolagus cuniculus
Development of single-molecule ubiquitination mediated fluorescence complementation to visualize protein ubiquitination dynamics in dendrites
TJZYF Improves Endometrial Receptivity through Regulating VEGF and PI3K/AKT Signaling Pathway - PMC
Journal
BioMed research international
VEGFA-Enriched Exosomes from Tendon-Derived Stem Cells Facilitate Tenocyte Differentiation, Migration, and Transition to a Fibroblastic Phenotype - PMC
Journal
BioMed research international
Resveratrol Synergistically Promotes BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells - PMC
Journal
Stem cells international
Resveratrol Synergistically Promotes BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells - PMC
Journal
Stem cells international
A Lipidated Peptide with Mitochondrial Membrane Localization in Human A549 Lung Cells: From Enhanced Cell-Penetrating Properties to Biological Activity Mechanism
Journal
ACS applied bio materials
Lysine demethylase KDM1A promotes cell growth via FKBP8-BCL2 axis in hepatocellular carcinoma
Journal
The Journal of biological chemistry
Myocyte enhancer factor 2D promotes hepatocellular carcinoma through AMOTL2/YAP signaling that inhibited by luteolin - PMC
Journal
International journal of clinical and experimental pathology
Molecular cloning, expression and functional analysis of STAT2 in orange-spotted grouper, Epinephelus coioides
Structures, chemical conversions, and cytotoxicity of tricholopardins C and D, two tricholoma triterpenoids from the wild mushroom Tricholoma pardinum
Journal
Natural products and bioprospecting
The Polysaccharides from the Aerial Parts of Bupleurum chinens e DC Attenuate Epilepsy-Like Behavior through Oxidative Stress Signaling Pathways
Journal
Oxidative medicine and cellular longevity
Identification of a key gene StAR-like-3 responsible for carotenoids accumulation in the noble scallop Chlamys nobilis
Journal
Food chemistry. Molecular sciences
Sesamol counteracts on metabolic disorders of middle-aged alimentary obese mice through regulating skeletal muscle glucose and lipid metabolism
Journal
Food & nutrition research