Flow cytometry analysis of human PBMC using PE Rabbit anti-Human CD4 mAb (A26596) , ABflo® 450 Rabbit anti-Human CD45 mAb (A25195), ABflo® 488 Rabbit anti-Human/Monkey CD8a mAb (A23345) and ABflo® 647 Rabbit anti-Human CD3 mAb (A26284) clearly classified positive and negative cells.
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
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