Flow Cytometry analysis of mouse spleen single-cell suspensions, using PE Rabbit anti-Mouse CD4 mAb (A25933) and PE/Cyanine7 Rabbit anti-Mouse CD8a mAb (A26742). The staining clearly distinguished between positive and negative cell populations.
Flow Cytometry analysis of MC38 tumor microenvironment, using ABflo® 647 Rabbit anti-Mouse CD8a mAb (A23904), PE Rabbit anti-Mouse CD4 mAb (A25933), ABflo® 450 Rabbit anti-Mouse CD45 mAb (A27197) and ABflo® 488 Rabbit anti-Mouse CD11b mAb (A24094), clearly classified positive and negative cells.
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背景信息
Predicted to enable several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in helper T cell enhancement of adaptive immune response. Acts upstream of or within several processes, including defense response to Gram-negative bacterium; positive regulation of calcium-mediated signaling; and positive regulation of peptidyl-tyrosine phosphorylation. Located in endoplasmic reticulum; external side of plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule).
