Flow Cytometry analysis of mouse spleen single-cell suspensions, using PE Rabbit anti-Mouse CD366 (TIM-3) mAb (A25729) and ABflo® 450 Rabbit anti-Mouse CD8a mAb (A25943). The staining clearly distinguished between positive and negative cell populations.
Predicted to enable metal ion binding activity. Involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and toll-like receptor signaling pathway. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including dorsal aorta; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).
