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活性验证

Recombinant Mouse FGF-18 Protein (RP03510)

说明书 收藏

Recombinant Mouse FGF-18 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

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货号: RP03510
促销价：   ￥3500
货    期：在线咨询货期
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详细信息

种属
Mouse
表达宿主
HEK293 Cells
Calculated MW
22.5 kDa
Observed MW
30-35 kDa
标签
C-His
纯度
≥ 95 % as determined by SDS-PAGE.
内毒素
< 1 EU/μg of the protein by LAL method.
制剂
Lyophilized from sterile 20 mM Mes, 500 mM NaCl, 1 mM EDTA, pH 6.6.Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
描述
Recombinant Mouse FGF-18 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Gly 207) of Mouse FGF-18 (Accession #NP_032031.1) fused with His at the C-terminus.
储存
Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.未开盖的干粉蛋白在 -20°C至-80°C可保存12个月；
复溶之后，蛋白溶液在-20°C及以下可保存3个月，在2-8℃可保存1周。
生物活性
1. Measured by its binding ability in a functional ELISA. 2. Immobilized mouse FGF18 at 10 μg/mL (100 μl/well) can bind Rat FGFR4 , The EC50 of Rat FGFR4is 0.44 μg/mL.

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背景信息

Recombinant Mouse FGF-18 Protein is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that FGF18 is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis.

基因ID
14172
Swiss Prot
O89101
别名
Fibroblast growth factor 18;FGF-18;zFGF5;Fgf18