产品和服务 / 产品类型 / 细胞系&裂解液 / KO细胞系
Recombinant Human Pro-neuregulin-1/NRG1 (Beta1) stimulates serum-free cell proliferation assay using MCF-7 human breast cancer cells. The ED50 for this effect is typically 0.62-2.48 ng/mL, corresponding to a specific activity of 4.03×105~1.61×106 units/mg.
Recombinant Human Pro-neuregulin-1/NRG1 (Beta1) Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.
neuregulin-1 (heregulin-1， NRG1) is a member of neuregulin family, which is comprised of four genes thatencode a large number of secreted or membrane-bound isoforms. All family members share an EGF-likedomain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified intotype I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors,concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylationand activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns andplay important roles during development of both the nervous system and the heart.
