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活性验证

Recombinant Human IL-22 Protein (RP01616)

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Recombinant Human IL-22 induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is 160-640 pg/mL.

Recombinant Human IL-22 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.

At concentrations ranging from 0.01 to 5 ng/mL, M5 factor (RP03505 IL1A,RP00212 IL17A,RP01616 IL22,RP00993 TNFα,RP00054 OSM)promotes the proliferation of HaCaT cells.

All(3)|
货号: RP01616
价 格：  1250.00
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详细信息

靶点
IL-22
细胞系
17.59 kDa
突变描述
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Mammalian cells such as human, rat and mouse cells are normally diploid with two alleles.
Homozygote: both alleles were knocked out, mRNA has no signal, no expression of proteins.
Heterozygote: only one allele was knocked out, the mRNA transcript levels was decreased compared to wild type, and the protein expression levels was also lower than that of the wild type.
敲除验证
17-35 kDa
产品组成
Ala34-Ile179
物种
HEK293 cells
保存条件
Store at -20℃
运输条件
Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Publishing research using RP01616? Please let us know so that we can cite the reference in this datasheet.

背景信息

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production.

基因ID
50616
Swiss Prot
Q9GZX6
别名
Interleukin-22; IL-22; Cytokine Zcyto18; IL-TIF; IL-D110; TIFa; TIFIL-23; ZCYTO18;IL22
研究领域

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