
产品和服务 / 产品类型 / ELISA试剂盒 / ELISA 抗体对
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Human Thyroglobulin Sandwich Immunoassay
| Recommended Concentration | Sample | ||
|---|---|---|---|
| ELISA | Capture | 0.15-0.6 μg/mL | Mouse anti-Human Thyroglobulin mAb (Cat. No. RMK0621) |
| Detection | 0.01-0.04 μg/mL | Mouse anti-Human Thyroglobulin mAb (Cat. No. RMK0622) | |
| Standard | 78.125-5000 pg/mL | Recombinant Human Thyroglobulin Protein |
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.