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Human IL-6 multiplex assay
Recommended Concentration | Sample | |
---|---|---|
Capture | 1-4 ug/ml | Rabbit anti-Human IL-6 mAb (CAP)(Cat. No. RM17650) |
Detection | 0.5-2ug/mL | Rabbit anti-Human IL-6 mAb (DET)(Cat. No. RM17651/RM17652) |
Standard | 1.4-1000pg/mL | Recombinant IL-6 Protein (Cat. No. RP00201) |
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates "classic signaling", whereas the binding of IL6 and soluble IL6R to IL6ST stimulates "trans-signaling". Alternatively, "cluster signaling" occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).