Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism
Super-enhancer-controlled positive feedback loop BRD4/ERα–RET–ERα promotes ERα-positive breast cancer
Journal
Nucleic acids research
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis - PMC
Journal
Nature communications
Regulation of an osteon-like concentric microgrooved surface on osteogenesis and osteoclastogenesis.
Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury
Journal
Basic Research in Cardiology
GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2
Journal
Journal of Experimental & Clinical Cancer
Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.
Encountering and Wrestling: Neutrophils Recognize and Defensively Degrade Graphene Oxide
Journal
Advanced healthcare materials
MiR-93 regulates vascular smooth muscle cell proliferation, and neointimal formation through targeting Mfn2
Journal
International Journal of Biological Sciences
Reticulon 2 promotes gastric cancer metastasis via activating endoplasmic reticulum Ca 2+ efflux-mediated ERK signalling
Journal
Cell death & disease
Species
Homo sapiens, Mus musculus
SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26.
Journal
Cell death & disease
New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.
Journal
Journal of Neuroinflammation
PcEiger links the Imd/Relish pathway to ROS production in the intestine of the red swamp crayfish
IP-10 Promotes Blood-Brain Barrier Damage by Inducing Tumor Necrosis Factor Alpha Production in Japanese Encephalitis
Journal
Frontiers in Immunology
Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1
Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells
Journal
Stem Cell Research & Therapy
Gossypol overcomes EGFR-TKIs resistance in non-small cell lung cancer cells by targeting YAP/TAZ and EGFRL858R/T790M.
Journal
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate
Journal
Journal of Translational Medicine
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma - PMC
Journal
Oxidative medicine and cellular longevity
Chlorothalonil exposure compromised mouse oocyte in vitro maturation through inducing oxidative stress and activating MAPK pathway
Journal
Ecotoxicology and environmental safety
Implication of human endogenous retrovirus W family envelope in hepatocellular carcinoma promotes MEK/ERK-mediated metastatic invasiveness and doxorubicin resistance
Polysaccharides from Hericium erinaceus Fruiting Bodies: Structural Characterization, Immunomodulatory Activity and Mechanism - PMC
Species
Homo sapiens, Mus musculus
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway - PMC
Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ
Journal
Biochimica et biophysica acta. Molecular basis of disease
Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice
Journal
Communications biology
Tanshinone IIA Inhibits Glutamate-Induced Oxidative Toxicity through Prevention of Mitochondrial Dysfunction and Suppression of MAPK Activation in SH-SY5Y Human Neuroblastoma Cells
Journal
Oxidative Medicine And Cellular Longevity
A Novel Fibromodulin Antagonist Peptide RP4 Exerts Antitumor Effects on Colorectal Cancer - PMC
Loss of PR55α promotes proliferation and metastasis by activating MAPK/AKT signaling in hepatocellular carcinoma
Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway
Icariin reduces Glu‐induced excitatory neurotoxicity via antioxidative and antiapoptotic pathways in SH‐SY5Y cells
Journal
Phytotherapy research : PTR
Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2
Journal
Molecular therapy oncolytics
The mechanism of ginger and its processed products in the treatment of estradiol valerate coupled with oxytocin-induced dysmenorrhea in mice via regulating …
The preventive effect and underlying mechanism of Rhus chinensis Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice
Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway
Journal
Frontiers in Molecular Neuroscience
CDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells
Journal
Frontiers in molecular neuroscience
Classical Signaling and Trans-Signaling Pathways Stimulated by Megalobrama amblycephala IL-6 and IL-6R
Journal
International journal of molecular sciences
Species
Ctenopharyngodon idellus
Vaccarin Regulates Diabetic Chronic Wound Healing through FOXP2/AGGF1 Pathways
Journal
International Journal of Molecular Sciences
Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia-Reperfusion Injury - PMC
Journal
International journal of molecular sciences
Effects of Sarcoptes scabiei Translationally Controlled Tumor Protein (TCTP) on Histamine Release and Degranulation of KU812 Cells - PMC
Journal
International journal of molecular sciences
Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 (CXCL13) in Hyperplastic Prostate - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens,Rattus norvegicus
Graphene Oxide Loaded on TiO2-Nanotube-Modified Ti Regulates the Behavior of Human Gingival Fibroblasts - PMC
Journal
International journal of molecular sciences
Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth
Journal
Comput Struct Biotechnol J
N-3, a novel synthetic derivative of bifendate, inhibits metastasis of triple-negative breast cancer via decreasing p38-regulated FOXC1 protein stability
Journal
Biochemical pharmacology
Species
Homo sapiens, Mus musculus
EGFR suppression contributes to growth inhibitory activity of G-quadruplex ligands in non-small cell lung cancers
Journal
Biochemical pharmacology
Plasma exosomes confer hypoxic pulmonary hypertension by transferring LOX-1 cargo to trigger phenotypic switching of pulmonary artery smooth muscle cells
Journal
Biochemical pharmacology
Mixed lineage kinase-like protein protects against Clostridium perfringens infection by enhancing NLRP3 inflammasome-extracellular traps axis - PMC
Hydroxycarboxylic Acid Receptor 2 Is a Zika Virus Restriction Factor That Can Be Induced by Zika Virus Infection Through the IRE1-XBP1 Pathway
Journal
Frontiers in Cellular and Infection Microbiology
Generation of multicellular tumor spheroids with micro-well array for anticancer drug combination screening based on a valuable biomarker of hepatocellular carcinoma - PMC
Journal
Frontiers in bioengineering and biotechnology
EGFR Activation Impairs Antiviral Activity of Interferon Signaling in Brain Microvascular Endothelial Cells During Japanese Encephalitis Virus Infection - PMC
Journal
Frontiers in microbiology
ANGPTL4 Regulates Psoriasis via Modulating Hyperproliferation and Inflammation of Keratinocytes - PMC
Journal
Frontiers in pharmacology
Species
Homo sapiens, Mus musculus
Therapeutic effect of fenofibrate for non-alcoholic steatohepatitis in mouse models is dependent on regime design - PMC
Journal
Frontiers in pharmacology
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites
Journal
Journal of agricultural and food chemistry
RNAbinding proteinregulated fibronectin is essential for EGFRactivated metastasis of head and neck squamous cell carcinoma
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Species
Homo sapiens, Mus musculus
Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling
TICRR Contributes to Tumorigenesis Through Accelerating DNA Replication in Cancers.
Journal
Frontiers in oncology
Imperatorin reduces the inflammatory response of atherosclerosis by regulating MAPKs signaling pathway in vivo and in vitro
Journal
International Immunopharmacology
Dexmedetomidine attenuates hepatic ischemia-reperfusion injury-induced apoptosis via reducing oxidative stress and endoplasmic reticulum stress
Journal
International immunopharmacology
Nuciferine alleviates intestinal inflammation by inhibiting MAPK/NF-κB and NLRP3/Caspase 1 pathways in vivo and in vitro
Journal
International immunopharmacology
Glymphatic improves inflammation and apoptosis after cerebral ischemia-reperfusion injury in mice through ERK signaling pathway
Journal
Molecular neurobiology
The ω-carboxyl group of 7-ketocholesteryl-9-carboxynonanoate mediates the binding of oxLDL to CD36 receptor and enhances caveolin-1 expression in macrophages
Journal
International Journal Of Biochemistry & Cell Biology
Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells - PMC
Metabolomic Profiles in the Intestine of Shrimp Infected by White Spot Syndrome Virus and Antiviral Function of the Metabolite Linoleic Acid in Shrimp
The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo
Journal
Journal of ethnopharmacology
GCRV-II invades monocytes/macrophages and induces macrophage polarization and apoptosis in tissues to facilitate viral replication and dissemination
Journal
Journal of virology
Broadleaf Mahonia attenuates granulomatous lobular mastitis?associated inflammation by inhibiting CCL?5 expression in macrophages
Journal
International Journal of Molecular Medicine
Coptisine inhibits neointimal hyperplasia through attenuating Pak1/Pak2 signaling in vascular smooth muscle cells without retardation of re-endothelialization
Effect of MiR-100-5p on proliferation and apoptosis of goat endometrial stromal cell in vitro and embryo implantation in vivo
Journal
Journal of cellular and molecular medicine
Melittin inhibits proliferation, migration and invasion of bladder cancer cells by regulating key genes based on bioinformatics and experimental assays.
Journal
Journal of Cellular and Molecular Medicine
Vaccarin enhances intestinal barrier function in type 2 diabetic mice
Anneslea fragrans Wall. ameliorates ulcerative colitis via inhibiting NF-κB and MAPK activation and mediating intestinal barrier integrity
In vitro and in vivo relaxation and anti-inflammation of natural flavonoids from Elaeagnus pungens leaf via L-type calcium channel and targeting MAPK signal pathway
Longan (Dimocarpus longan Lour.) Aril ameliorates cognitive impairment in AD mice induced by combination of D-gal/AlCl3 and an irregular diet via RAS/MEK/ERK signaling pathway
Journal
Journal Of Ethnopharmacology
6H2L, a novel synthetic derivative of bifendate, induces apoptosis in hepatoma cells via mitochondrial and MAPK pathway
Effect of Fructus Ligustri Lucidi on osteoblastic like cell-line MC3T3-E1
Journal
Journal Of Ethnopharmacology
Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination
Journal
Scientific Reports
Species
Homo sapiens, Mus musculus
Transcriptional regulation of miR-15b by c-Rel and CREB in Japanese encephalitis virus infection
Journal
Scientific Reports
DMBA acts on cumulus cells to desynchronize nuclear and cytoplasmic maturation of pig oocytes
Journal
Scientific Reports
The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia - PMC
Journal
Reproductive biology and endocrinology : RB&E
Melatonin Administration Accelerates Puberty Onset in Mice by Promoting FSH Synthesis
1-2 T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis - PMC
Journal
Journal of orthopaedic translation
Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro
COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-κB signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis
Journal
PLoS neglected tropical diseases
Gambogic Acid Efficiently Kills Stem-Like Colorectal Cancer Cells by Upregulating ZFP36 Expression
Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Cadherin-11 Deficiency Attenuates Ang-II-Induced Atrial Fibrosis and Susceptibility to Atrial Fibrillation
Species
Homo sapiens, Mus musculus
Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo
Legumain Inhibitor Prevents Breast Cancer Bone Metastasis by Attenuating Osteoclast Differentiation and Function
Species
Homo sapiens, Mus musculus
Nutrient sensing signaling functions as the sensor and regulator of immunometabolic changes in grass carp during Flavobacteriumcolumnare infection.
Journal
Fish & shellfish immunology
Species
Mycobacterium tuberculosis
Iodixanol activation of mast cells: implications in the pathogenesis of iodixanol-induced delayed cutaneous adverse reactions
MicroRNA miR-212-5p Regulates the MEK/ERK Signaling Pathway by Targeting A-Raf proto-oncogene serine/threonine-protein kinase (ARAF) to Regulate Cowshed PM2.5-Induced NR8383 Apoptosis - PMC
Super Enhancer Driven Hyaluronan Synthase 3 Promotes Malignant Progression of Nasopharyngeal Carcinoma - PMC
Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway
Journal
Drug Des Devel Ther
Oridonin Attenuates Thioacetamide-Induced Osteoclastogenesis Through MAPK/NF-κB Pathway and Thioacetamide-Inhibited Osteoblastogenesis Through …
Journal
Calcified tissue international
Species
Mus musculus,Rattus norvegicus
ERK inhibition aids IFN- promoter activation during EV71 infection by blocking CRYAB degradation in SH-SY5Y cells
Journal
Pathogens and disease
Astragaloside IV protects human cardiomyocytes from hypoxia/reoxygenation injury by regulating miR-101a
Low let-7d microRNA levels in chick embryos enhance innate immunity against Mycoplasma gallisepticum by suppressing the mitogen-activated protein kinase pathway - PMC
Journal
Veterinary research
DCZ3301, an aryl-guanidino agent, inhibits ocular neovascularization via PI3K/AKT and ERK1/2 signaling pathways
Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation.
YAP confers resistance to vandetanib in medullary thyroid cancer
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
Bi-functional KIT-PR1P peptides combine with VEGF to protect ischemic kidney in rats by targeting to Kim-1 - PMC
Journal
Regenerative therapy
The Anti-Apoptotic Role of COX-2 during In Vitro Infection of Human Intestinal Cell Line by Giardia duodenalis and The Potential Regulators
Journal
Infection and immunity
Rutin treats myocardial damage caused by pirarubicin via regulating miR‐22‐5p‐regulated RAP1/ERK signaling pathway
Journal
J Biochem Mol Toxicol
Resveratrol attenuates hydrogen peroxide‑induced apoptosis, reactive oxygen species generation, and PSGL‑1 and VWF activation in human umbilical vein endothelial cells, potentially via MAPK signalling pathways
Journal
Molecular medicine reports
Heat shock protein 90α couples with the MAPK signaling pathway to determine meiotic maturation of porcine oocytes
Journal
Journal of Animal Science
SGK1 inhibits PM2. 5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells
Journal
Biochemical and Biophysical Research Communications
The polysaccharide from Camellia oleifera fruit shell enhances immune responses via activating MAPKs and NF-κB signaling pathways in RAW264.7 macrophages - PMC
Journal
Food & nutrition research
Serum Exosomes Attenuate H2O2-Induced Apoptosis in Rat H9C2 Cardiomyocytes via ERK1/2
Journal
Journal of Cardiovascular Translational Research
The coordinated effects of Apatinib and Tripterine on the proliferation, invasiveness and apoptosis of human hepatoma Hep3B cells.
Novel Indolyl-Benzimidazole Compounds Promote in vitro Wound Healing and Osteogenic Differentiation of Pluripotent Cells
Journal
Frontiers in bioscience (Landmark edition)
Lysosomal dysfunction disturbs porcine oocyte maturation and developmental capacity by disorganizing chromosome/cytoskeleton and activating autophagy/apoptosis.
Gefitinib represses JAK-STAT signaling activated by CRTC1-MAML2 fusion in mucoepidermoid carcinoma cells
Journal
Current cancer drug targets
PP2Ac knockdown attenuates lipotoxicity-induced pancreatic -cell dysfunction and apoptosis - PMC
Journal
Experimental and therapeutic medicine
PP2Ac knockdown attenuates lipotoxicity-induced pancreatic -cell dysfunction and apoptosis - PMC
Journal
Experimental and therapeutic medicine
Autophagy inhibitors alleviate Japanese encephalitis virus-induced cerebral inflammation in mice
Journal
Archives of virology
Antipharyngitis Effects of Syringa oblata L. Ethanolic Extract in Acute Pharyngitis Rat Model and Anti-Inflammatory Effect of Ir-Idoids in LPS-Induced RAW 264.7 Cells
Journal
Evid Based Complement Alternat Med
Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice
Journal
Evid Based Complement Alternat Med
NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
SDC1 knockdown induces epithelial–mesenchymal transition and invasion of gallbladder cancer cells via the ERK/Snail pathway
Novel genetically engineered H3.3G34R model reveals cooperation with ATRX loss in upregulation of Hoxa cluster genes and promotion of neuronal lineage - PMC
Journal
Neuro-oncology advances