Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase
Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.
Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration - PMC
Journal
Signal transduction and targeted therapy
A tissue specific-infection mouse model of SARS-CoV-2 - PMC
Species
Homo sapiens, Mus musculus
Engineering and Characterization of an Artificial Drugcarrying Vesicles Nanoplatform for Enhanced Specifically Targeted Therapy of Glioblastoma
Journal
Advanced materials (Deerfield Beach, Fla.)
A Microbiota-Derived Bacteriocin Targets the Host to Confer Diarrhea Resistance in Early-Weaned Piglets.
Journal
Cell host & microbe
Species
Mus musculus,Sus scrofa
Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival
Journal
Cell host & microbe
Artificial Macrophage with Hierarchical Nanostructure for Biomimetic Reconstruction of Antitumor Immunity - PMC
Journal
Nano-micro letters
RNase H1 facilitates recombinase recruitment by degrading DNARNA hybrids during meiosis
Journal
Nucleic acids research
Landscape of enhancer disruption and functional screen in melanoma cells - PMC
The REN4 rheostat dynamically coordinates the apical and lateral domains of Arabidopsis pollen tubes.
Species
Arabidopsis thaliana
Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases - PMC
Journal
Nature communications
URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers - PMC
Journal
Nature communications
An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping - PMC
Journal
Nature communications
The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice - PMC
Journal
Nature communications
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway
Genetic and Pharmacological Inhibition of Astrocytic Mysm1 Alleviates DepressiveLike Disorders by Promoting ATP Production
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Species
Homo sapiens, Mus musculus
Glutathione Pulse Therapy: Promote Spatiotemporal Delivery of Reduction‐Sensitive Nanoparticles at the "Cellular Level" and Synergize PD‐1 Blockade Therapy
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance
Matrix promote mesenchymal stromal cell migration with improved deformation via nuclear stiffness decrease.
Repurposing ICG enables MR/PA imaging signal amplification and iron depletion for iron-overload disorders
Intracellular delivery of nitric oxide enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction - PMC
Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson's disease treatment
Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites
Journal
Journal of pharmaceutical analysis
Cleaved SPP1-rich extracellular vesicles from osteoclasts promote bone regeneration via TGF1/SMAD3 signaling
The DRD2 antagonist haloperidol mediates autophagy-induced ferroptosis to increase temozolomide sensitivity by promoting endoplasmic reticulum stress in …
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy
Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation
Journal
Proceedings of the National Academy of Sciences of the United States of America
Pharmacological inhibition of MDM4 alleviates pulmonary fibrosis - PMC
Organ-specific cholesterol metabolic aberration fuels liver metastasis of colorectal cancer
Delivery of hydroxycamptothecin via sonoporation: An effective therapy for liver fibrosis
Journal
Journal of controlled release : official journal of the Controlled Release Society
Reactive oxygen species trigger NF-B-mediated NLRP3 inflammasome activation involvement in low-dose CdTe QDs exposure-induced hepatotoxicity
Epidermal Growth Factor potentiates EGFR (Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated
Ultra-small polydopamine nanomedicine-enabled antioxidation against senescence - PMC
Journal
Materials today. Bio
Moderate mechanical stimulation rescues degenerative annulus fibrosus by suppressing caveolin-1 mediated pro-inflammatory signaling pathway
ESRRA promotes gastric cancer development by regulating the CDC25C/CDK1/CyclinB1 pathway via DSN1
Injectable Bacteria-Sensitive
Hydrogel Promotes Repair
of Infected Fractures via Sustained Release of miRNA Antagonist - PMC
Journal
ACS applied materials & interfaces
Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNALys
Journal
Science China. Life sciences
Ginsenoside Rh1, a novel casein kinase II subunit alpha (CK2) inhibitor, retards metastasis via disrupting HHEX/CCL20 signaling cascade involved in tumor
Journal
Pharmacological research
LW-213 induces immunogenic tumor cell death via ER stress mediated by lysosomal TRPML1
Species
Homo sapiens, Mus musculus
Tumor-targeted Delivery of Copper-manganese Biomineralized Oncolytic Adenovirus for Colorectal Cancer Immunotherapy
Journal
Acta biomaterialia
Platelet Membrane-Coated Bio-Nanoparticles of Indocyanine Green/Elamipretide for NIR Diagnosis and Antioxidant Therapy in Acute Kidney Injury
Journal
Acta Biomaterialia
Sepiapterin reductase promotes hepatocellular carcinoma progression via FoxO3a/Bim signaling in a nonenzymatic manner
Journal
Cell Death & Disease
Lmod2piggyBac mutant mice exhibit dilated cardiomyopathy.
Journal
Cell and Bioscience
SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair - PMC
Fucose promotes intestinal stem cell-mediated intestinal epithelial development through promoting Akkermansia-related propanoate metabolism - PMC
Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice
Journal
Journal Of Nanobiotechnology
Triptolide with hepatotoxicity and nephrotoxicity used in local delivery treatment of myocardial infarction by thermosensitive hydrogel - PMC
Journal
Journal of nanobiotechnology
Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP/LOXL2 pathway - PMC
Journal
Journal of nanobiotechnology
Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation - PMC
Journal
Journal of nanobiotechnology
Validation of protein biological markers of lamb meat quality characteristics based on the different muscle types
Nucleotide-Binding Oligomerization Domain 1 (NOD1) Positively Regulates Neuroinflammation during Japanese Encephalitis Virus Infection
Journal
Microbiology spectrum
Japanese Encephalitis Virus NS1′ Protein Interacts with Host CDK1 Protein to Regulate Antiviral Response
Targeting Notch1-YAP circuit reprograms macrophage polarization and alleviates acute liver injury in mice
Journal
Cellular and molecular gastroenterology and hepatology
Characterization of myeloperoxidase and its contribution to antimicrobial effect on extracellular traps in flounder (Paralichthys olivaceus) - PMC
Journal
Frontiers in immunology
Duck LGP2 Downregulates RIG-I Signaling Pathway-Mediated Innate Immunity Against Tembusu Virus - PMC
Journal
Frontiers in immunology
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence
Journal
Frontiers in immunology
Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples
Journal
Frontiers in immunology
Regulatory networks in mechanotransduction reveal key genes in promoting cancer cell stemness and proliferation.
CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin
BCL2 is a major regulator of haploidy maintenance in murine embryonic stem cells
Journal
Cell proliferation
Bone marrow‐derived mesenchymal stem cells attenuate complete Freund's a djuvant‐induced inflammatory pain by inhibiting the expression of P2X3
Journal
Cell proliferation
Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS - PMC
The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis - PMC
Journal
Cellular & molecular biology letters
Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemia-reperfusion injury - PMC
Journal
Cellular & molecular biology letters
Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids - PMC
Journal
Molecular metabolism
Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies - PMC
Journal
Clinical and translational medicine
KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation - PMC
Journal
Journal of translational medicine
Species
Homo sapiens, Mus musculus
ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway - PMC
Journal
Journal of translational medicine
Efficacy of a novel glioma therapy based on ferroptosis induced by layered double hydroxide loaded with simvastatin
Journal
Environmental research
Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis
Journal
Stem Cell Res Ther
Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer (CRPC).
Journal
Journal of medicinal chemistry
Sulfated fuco-manno-glucuronogalactan alleviates pancreatic beta cell senescence via PI3K/Akt/FoxO1 pathway
Journal
International journal of biological macromolecules
Depletion of LOXL2 improves respiratory capacity: From air-breathing fish to mammal under hypoxia
Journal
International journal of biological macromolecules
Depletion of LOXL2 improves respiratory capacity: From air-breathing fish to mammal under hypoxia
Journal
International journal of biological macromolecules
A fluorescent probe for early detection of melanoma and its metastasis by specifically imaging tyrosinase activity in a mouse model
Journal
Analytical chemistry
Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer's disease
Journal
Translational psychiatry
Correction: Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation - PMC
Journal
Translational psychiatry
Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress - PMC
Journal
Antioxidants (Basel, Switzerland)
Species
Mus musculus,Rattus norvegicus
Selenium Deficiency-Induced Oxidative Stress Causes Myocardial Injury in Calves by Activating Inflammation, Apoptosis, and Necroptosis - PMC
Journal
Antioxidants (Basel, Switzerland)
Lotus Bee Pollen Extract Inhibits Isoproterenol-Induced Hypertrophy via JAK2/STAT3 Signaling Pathway in Rat H9c2 Cells - PMC
Journal
Antioxidants (Basel, Switzerland)
The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP+ - PMC
The deubiquitinase USP38 affects cellular functions through interacting with LSD1.
Journal
Biological research
LncRNAH19 improves insulin resistance in skeletal muscle by regulating heterogeneous nuclear ribonucleoprotein A1
Journal
Cell Commun Signal
Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes.
Journal
Cell Communication and Signaling
Modulation of apoptosis and Inflammasome activation in chondrocytes: co-regulatory role of Chlorogenic acid - PMC
Journal
Cell communication and signaling : CCS
Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ER axis - PMC
Journal
Cell communication and signaling : CCS
Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration - PMC
Journal
Cell communication and signaling : CCS
Species
Homo sapiens, Mus musculus
Insights into the hippocampus proteome and phosphorylation modification alterations in C57BL/6 revealed the memory improvement mechanisms of a walnut-derived peptide
Journal
Food research international (Ottawa, Ont.)
MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis
Journal
Biomed Pharmacother
Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway
Journal
Biomedicine & Pharmacotherapy
P-coumaric acid ameliorates A2535-induced brain damage in mice by modulating gut microbiota and serum metabolites
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Microalga Chlorella sp. extract induced apoptotic cell death of cholangiocarcinoma via AKT/mTOR signaling pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate
Journal
Journal of Translational Medicine
The chromosome-level genome and key genes associated with mud-dwelling behavior and adaptations of hypoxia and noxious environments in loach (Misgurnus anguillicaudatus) - PMC
Species
Misgurnus anguillicaudatus
Overexpression of PRDX2 in Adipose-Derived Mesenchymal Stem Cells Enhances the Therapeutic Effect in a Neurogenic Erectile Dysfunction Rat Model by Inhibiting Ferroptosis - PMC
Journal
Oxidative medicine and cellular longevity
The von Hippel-Lindau Tumor Suppressor Gene Mutations Modulate Lipocalin-2 Expression in Ferroptotic-Inflammatory Pathways - PMC
Journal
Oxidative medicine and cellular longevity
Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats
Journal
Acta Pharmacol Sin
Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer.
Journal
Acta pharmacologica Sinica
Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/GSK-3β pathways in broilers
Journal
Ecotoxicol Environ Saf
Alleviative effect of quercetin against reproductive toxicity induced by chronic exposure to the mixture of phthalates in male rats
Journal
Ecotoxicology and environmental safety
Acute nitrite exposure interferes with intestinal thyroid hormone homeostasis in grass carp (Ctenopharyngodon idellus)
Journal
Ecotoxicology and environmental safety
Species
Ctenopharyngodon idellus
Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway
Species
Homo sapiens, Mus musculus
Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway - PMC
Journal
Cell death discovery
Development of cell-permeable peptide-based PROTACs targeting estrogen receptor α
Journal
European Journal of Medicinal Chemistry
Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance.
Journal
European journal of medicinal chemistry
Benzoxazinone-containing 3, 5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer
Journal
European Journal of medicinal chemistry
Sphingosine-1-phosphate receptor 3 is implicated in BBB injury via the CCL2-CCR2 axis following acute intracerebral hemorrhage
Hollow Hydroxyapatite Microspheres Loaded with rhCXCL13 to Recruit BMSC for Osteogenesis and Synergetic Angiogenesis to Promote Bone Regeneration in Bone Defects - PMC
Journal
International journal of nanomedicine
Biocompatible Assessment of Erythrocyte Membrane-Camouflaged Polymeric PLGA Nanoparticles in Pregnant Mice: Both on Maternal and Fetal/Juvenile Mice - PMC
Journal
International journal of nanomedicine
Unraveling the role of Epac1-SOCS3 signaling in the development of neonatal-CRD-induced visceral hypersensitivity in rats - PMC
Journal
CNS neuroscience & therapeutics
Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
The potential mechanism of Fructus Ligustri Lucidi promoting osteogenetic differentiation of bone marrow mesenchymal stem cells based on network pharmacology, molecular docking and experimental identification
The effect of insulin and kruppel like factor 10 on osteoblasts in the dental implant osseointegration in diabetes mellitus patients - PMC
GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRβ/Akt/NF-κB/NLRP3 pathway
Low SCRIB expression in fibroblasts promotes invasion of lung cancer cells
Adipose specific aptamer adipo-8 recognizes and interacts with APMAP to ameliorates fat deposition in vitro and in vivo
Schisantherin A causes endothelium-dependent and -independent vasorelaxation in isolated rat thoracic aorta
Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs.
Effect of Moderate-Intense Training and Detraining on Glucose Metabolism, Lipid Profile, and Liver Enzymes in Male Wistar Rats: A Preclinical Randomized Study - PMC
Stingless Bee (Heterotrigona Itama) Honey and Its Phenolic-Rich Extract Ameliorate Oxidant-Antioxidant Balance via KEAP1-NRF2 Signalling Pathway - PMC
Chlorogenic acid suppresses mitochondrial apoptotic effectors Bax/Bak to counteract Nod-like receptor pyrin domain 3 (NLRP3) inflammasome in thiram exposed chondrocytes
Sarsasapogenin attenuates Alzheimer-like encephalopathy in diabetes
Sarsasapogenin alleviates diabetic nephropathy through suppression of chronic inflammation by down-regulating PAR-1: in vivo and in vitro study
Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1β reduction in thiram exposed chondrocytes via caspase-3/caspase-7 pathway
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-B/NLRP3 pathways
Journal
Biochimica et biophysica acta. Molecular basis of disease
Genomic and functional evidence reveals convergent evolution in fishes on the Tibetan Plateau
Ketogenic diet alleviates renal fibrosis in mice by enhancing fatty acid oxidation through the free fatty acid receptor 3 pathway - PMC
Journal
Frontiers in nutrition
ATF4 Transcriptionally Activates SHH to Promote Proliferation, Invasion, and Migration of Gastric Cancer Cells - PMC
Elucidation of the Molecular Mechanisms Underlying Sorafenib-Induced Hepatotoxicity
Journal
Oxidative Medicine and Cellular Longevity
Zinc Finger Protein BCL11A Contributes to the Abortive Infection of Hirame novirhabdovirus (HIRRV) in B Lymphocytes of Flounder (Paralichthys olivaceus)
Journal
Journal of virology
Species
Paralichthysolivaceus
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release - PMC
Ultrasonic Microbubble Cavitation Deliver Gal-3 shRNA to Inhibit Myocardial Fibrosis after Myocardial Infarction - PMC
MicroRNA-375-3p enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.
A small nucleolar RNA, SNORD126, promotes adipogenesis in cells and rats by activating the PI3K–AKT pathway
Journal
Journal of cellular physiology
Effects of phosphoglycerate kinase 1 and pyruvate kinase M2 on metabolism and physiochemical changes in postmortem muscle - PMC
Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer
Journal
Cancer cell international
CircRAD23B promotes proliferation and carboplatin resistance in ovarian cancer cell lines and organoids - PMC
Journal
Cancer cell international
Targeting inflammation-associated AMPK//Mfn-2/MAPKs signaling pathways by baicalein exerts anti-atherosclerotic action
DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1 - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Inhibition of checkpoint kinase prevents human oocyte apoptosis induced by chemotherapy and allows enhanced tumour chemotherapeutic efficacy
Journal
Human reproduction (Oxford, England)
Naringenin prevents TNF-α-induced gut-vascular barrier disruption associated with inhibiting the NF-κB-mediated MLCK/p-MLC and NLRP3 pathways
Oleanolic acid, a small-molecule natural product, inhibits ECM degeneration in osteoarthritis by regulating the Hippo/YAP and Wnt/-catenin pathways
The role of SOCS3 in the hypothalamic paraventricular nucleus in rat model of inflammatory pain
Journal
Journal of Inflammation (London, England)
Identification of the key immune-related genes in aneurysmal subarachnoid hemorrhage - PMC
Journal
Frontiers in molecular neuroscience
Down-Regulation of MiR-181c-5p Promotes Epithelial-to-Mesenchymal Transition in Laryngeal Squamous Cell Carcinoma via Targeting SERPINE1
Knockdown of insulin-like growth factor 2 gene disrupts mitochondrial functions in the liver
The Effect of miR-140-5p with HDAC4 towards Growth and Differentiation Signaling of Chondrocytes in Thiram-Induced Tibial Dyschondroplasia - PMC
Journal
International journal of molecular sciences
Application
WB, IHC, IF, IP
Application of Novel Transcription Factor Machine Learning Model and Targeted Drug Combination Therapy Strategy in Triple Negative Breast Cancer - PMC
Journal
International journal of molecular sciences
NUF2 Promotes Breast Cancer Development as a New Tumor Stem Cell Indicator - PMC
Journal
International journal of molecular sciences
Gain-of-Function p53N236S Mutation Drives the Bypassing of HRasV12-Induced Cellular Senescence via PGC-1α - PMC
Journal
International journal of molecular sciences
Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes - PMC
Journal
International journal of molecular sciences
Combination RSL3 Treatment Sensitizes Ferroptosis- and EGFR-Inhibition-Resistant HNSCCs to Cetuximab - PMC
Journal
International journal of molecular sciences
Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 (CXCL13) in Hyperplastic Prostate - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens,Rattus norvegicus
Hsp40 protein DNAJB6 interacts with viral NS3 and inhibits the replication of the Japanese encephalitis virus
Journal
International journal of molecular sciences
The chemical characteristics of different sodium iron ethylenediaminetetraacetate sources and their relative bioavailabilities for broilers fed with a conventional corn-soybean meal diet - PMC
Journal
Journal of animal science and biotechnology
Lysosomal dysfunction in Schwann cells is involved in bortezomib-induced peripheral neuropathy
Journal
Archives of toxicology
Species
Rattus norvegicus,Mus musculus
Casein kinase 2 attenuates brain injury induced by intracerebral hemorrhage via regulation of NR2B phosphorylation - PMC
Journal
Frontiers in cellular neuroscience
Studying Antifatigue Mechanism of Tyr-Pro-Leu-Pro in Exercise Mice Using Label-Free Proteomics
Journal
Journal of agricultural and food chemistry
Species
Mus musculus,Other
Gasdermin D promotes hyperuricemia-induced renal tubular injury through RIG-I/caspase-1 pathway - PMC
Circ_0022920 Maintains the Contractile Phenotype of Human Aortic Vascular Smooth Muscle Cells Via Sponging microRNA-650 and Promoting Transforming Growth Factor Beta Receptor 1 Expression in Angiotensin II-Induced Models for Aortic Dissection - PMC
Journal
Journal of the American Heart Association
Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis - PMC
Marine bromophenol bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane inhibits the proliferation, migration, and invasion of hepatocellular carcinoma cells via modulating β1-integrin/FAK signaling
Porphyromonas gingivalis Induces Bisphosphonate-Related Osteonecrosis of the Femur in Mice - PMC
Journal
Frontiers in cellular and infection microbiology
Fangchinoline inhibits the PEDV replication in intestinal epithelial cells via autophagic flux suppression - PMC
Journal
Frontiers in microbiology
Fur functions as an activator of T6SS-mediated bacterial dominance and virulence in Aeromonas hydrophila - PMC
Journal
Frontiers in microbiology
Application
Hcp protein secretion assay
Species
aeromonas hydrophila
PAGln, an Atrial Fibrillation-Linked Gut Microbial Metabolite, Acts as a Promoter of Atrial Myocyte Injury - PMC
Novel prognostic features and personalized treatment strategies for mitochondria-related genes in glioma patients - PMC
Journal
Frontiers in endocrinology
Construction of novel hypoxia-related gene model for prognosis and tumor microenvironment in endometrial carcinoma - PMC
Journal
Frontiers in endocrinology
Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol
Journal
The American journal of Chinese medicine
15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo.
Journal
Frontiers in Pharmacology
Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1
Small-Conductance Ca 2+-Activated K + Channels 2 in the Hypothalamic Paraventricular Nucleus Precipitates Visceral Hypersensitivity Induced by Neonatal Colorectal Distension in Rats
Small-Conductance Ca2+-Activated K+ Channel 2 in the Dorsal Horn of Spinal Cord Participates in Visceral Hypersensitivity in Rats.
Journal
Frontiers in Pharmacology
TJ-M2010-5, a novel CNS drug candidate, attenuates acute cerebral ischemia-reperfusion injury through the MyD88/NF-κB and ERK pathway - PMC
Journal
Frontiers in pharmacology
EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway - PMC
Journal
Frontiers in pharmacology
Tetramethylpyrazine ameliorates acute lung injury by regulating the Rac1/LIMK1 signaling pathway - PMC
Journal
Frontiers in pharmacology
Comprehensive analysis of hypoxia-related genes for prognosis value, immune status, and therapy in osteosarcoma patients - PMC
Journal
Frontiers in pharmacology
Anti-oxidative and anti-inflammatory activities of the ethanol extract of edible flower from Chimonanthus praecox - PMC
Journal
Frontiers in pharmacology
Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation via regulating microglia M1/M2 polarization and JAK1/STAT3 pathway - PMC
Journal
Frontiers in pharmacology
Identification of fatty acid-related subtypes, the establishment of a prognostic signature, and immune infiltration characteristics in lung adenocarcinoma - PMC
A two-gene random forest model to diagnose osteoarthritis based on RNA-binding protein-related genes in knee cartilage tissue - PMC
Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1‐YAP‐PROX1 axis
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
A Novel Hemocyte-Specific Small Protein Participates in White Spot Syndrome Virus Infection via Binding to Viral Envelope Protein - PMC
Unique regulation of TiO2 nanoporous topography on macrophage polarization via MSC-derived exosomes - PMC
Journal
Regenerative biomaterials
Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach
Journal
Journal of enzyme inhibition and medicinal chemistry
Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta gene as a tumour suppressor in stomach adenocarcinoma - PMC
Journal
Frontiers in oncology
Comprehensive analysis of fatty acid and lactate metabolism-related genes for prognosis value, immune infiltration, and therapy in osteosarcoma patients - PMC
Journal
Frontiers in oncology
LncRNA THRIL, transcriptionally activated by AP-1 and stabilized by METTL14-mediated m6A modification, accelerates LPS-evoked acute injury in alveolar epithelial
Journal
International immunopharmacology
Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury via inhibiting NOD-like receptor 3/caspase-1/gasdermin D-mediated pyroptosis
Journal
International immunopharmacology
Cytoplasmic HMGB1 induces renal tubular ferroptosis after ischemia/reperfusion
Journal
International immunopharmacology
Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo
Journal
International immunopharmacology
Metabolic Disorder of Extracellular Matrix Mediated by Decorin Upregulation Is Associated With Brain Arteriovenous Malformation Diffuseness
Journal
Front Aging Neurosci
Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection - PMC
Journal
Frontiers in aging neuroscience
Integrated Analysis of Chromatin and Transcriptomic Profiling Identifies PU. 1 as a Core Regulatory Factor in Microglial Activation Induced by Chronic
Journal
Molecular neurobiology
Isobavachalcone's Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3
Journal
Molecular neurobiology
E2F1-mediated ectopic expression of PP1A promotes breast cancer progression via activation of YAP1
Journal
The international journal of biochemistry & cell biology
GAPDH Is a Novel Ferroptosis-Related Marker and Correlates with Immune Microenvironment in Lung Adenocarcinoma - PMC
PPAR- with its anti-fibrotic action could serve as an effective therapeutic target in T-2 toxin-induced cardiac fibrosis of rats
Lycopene ameliorates atrazine-induced spatial learning and memory impairments by inhibiting ferroptosis in the hippocampus of mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Respiratory exposure to graphene quantum dots causes fibrotic effects on lung, liver and kidney of mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis
Journal
Apoptosis : an international journal on programmed cell death
Resveratrol Inhibits Proliferation and Differentiation of Porcine Preadipocytes by a Novel LincRNA-ROFM/miR-133b/AdipoQ Pathway - PMC
Journal
Foods (Basel, Switzerland)
S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid
Journal
The Journal of Biological Chemistry
Chronic intranasal corticosteroid treatment induces degeneration of olfactory sensory neurons in normal and allergic rhinitis mice
Journal
International forum of allergy & rhinology
Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1.
Journal
The journal of pain
Lipidomics Study of Sepsis-Induced Liver and Lung Injury under Anti-HMGB1 Intervention
Journal
Journal of proteome research
Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux
Adropin attenuates pancreatitis-associated lung injury through PPAR phosphorylation-related macrophage polarization - PMC
Journal
International journal of molecular medicine
Discovery of a potent and selective CBP bromodomain inhibitor (Y08262) for treating acute myeloid leukemia
Journal
Bioorganic chemistry
Changes in the expression and function of the PDE5 pathway in the obstructed urinary bladder
Species
Homo sapiens, Mus musculus
Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice
MicroRNA-129-1-3p protects cardiomyocytes from pirarubicin-induced apoptosis by down-regulating the GRIN2D-mediated Ca2+ signalling pathway
Journal
Journal of Cellular and Molecular Medicine
Species
Mus musculus,Rattus norvegicus
lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis.
Journal
Journal of cellular and molecular medicine
Roles of nucleus accumbens shell small-conductance calcium-activated potassium channels in the conditioned fear freezing
Journal
Journal of psychiatric research
Preclinical Studies of Chiauranib Show It Inhibits Transformed Follicular Lymphoma through the VEGFR2/ERK/STAT3 Signaling Pathway - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
Mechanism of Erianin anti-triple negative breast cancer based on transcriptomics methods and network pharmacology - PMC
Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier
The enhancing effect of 5-HT on phasic contractions of human isolated distal ureter and the mechanisms mediating these effects
Journal
European journal of pharmacology
Polyunsaturated fatty acids drive neutrophil extracellular trap formation in nonalcoholic steatohepatitis
Journal
European journal of pharmacology
Fisetin suppresses ferroptosis through Nrf2 and attenuates intervertebral disc degeneration in rats
Journal
European journal of pharmacology
Inhibition of MALT1 reduces ferroptosis in rat hearts following ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway
Journal
European journal of pharmacology
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-B pathway
Journal
European journal of pharmacology
Selenium alleviates endoplasmic reticulum calcium depletion-induced endoplasmic reticulum stress and apoptosis in chicken myocardium after mercuric chloride …
Journal
Environmental science and pollution research international
Honokiol inhibits interleukin-induced angiogenesis in the NSCLC microenvironment through the NF-κB signaling pathway
Journal
Chemico-biological interactions
Functional Characterization and Development of Novel Human Kinase Insert Domain Receptor Chimeric Antigen Receptor T-cells for Immunotherapy of Non …
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Bile Acids Promote Hepatic Biotransformation and Excretion of Aflatoxin B1 in Broiler Chickens - PMC
Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway
Journal
Drug development research
Embryonic stem cell-derived extracellular vesicle-mimetic nanovesicles rescue erectile function by enhancing penile neurovascular regeneration in the streptozotocin-induced diabetic mouse.
Journal
Scientific Reports
Transcriptional regulation of miR-15b by c-Rel and CREB in Japanese encephalitis virus infection
Journal
Scientific Reports
Testosterone promotion effect of Eucommia ulmoides staminate flower via the steroidogenic pathway and potential hormonal mechanism - PMC
Journal
Scientific reports
TMT-Based Proteomics Reveal the Mechanism of Action of Amygdalin against Rheumatoid Arthritis in a Rat Model through Regulation of Complement and Coagulation Cascades - PMC
Journal
Molecules (Basel, Switzerland)
Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 Pathway - PMC
Journal
Molecules (Basel, Switzerland)
GDNF promotes the proliferation and osteogenic differentiation of jaw bone marrow mesenchymal stem cells via the Nr4a1/PI3K/Akt pathway
Journal
Cellular signalling
Exogenous hydrogen sulfide inhibits the senescence of cardiomyocytes through modulating mitophagy in rats
Journal
Cellular signalling
SIRT1 ameliorated septic associated-lung injury and macrophages apoptosis via inhibiting endoplasmic reticulum stress
Journal
Cellular signalling
DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer
Journal
Cellular Signalling
Nrf2-/- regulated lung DNA demethylation and CYP2E1 DNA methylation under PM2.5 exposure - PMC
Journal
Frontiers in genetics
High GTSE1 expression promotes cell proliferation, metastasis and cisplatin resistance in ccRCC and is associated with immune infiltrates and poor prognosis - PMC
Journal
Frontiers in genetics
Chronic Restraint Stress-Induced Muscle Atrophy Leads to Fatigue in Mice by Inhibiting the AMPK Signaling Pathway
YAP1 activation promotes epithelial-mesenchymal transition and cell survival of renal cell carcinoma cells under shear stress
Cuproptosisrelated miRNAs signature and immune infiltration characteristics in colorectal cancer
PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A
Disinhibition of PVN-projecting GABAergic neurons in AV region in BNST participates in visceral hypersensitivity in rats
Journal
Psychoneuroendocrinology
BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis
Overexpression of Annexin A2 Receptor Inhibits Neovascularization via the Promotion of Krüppel-Like Transcription Factor 2
Journal
Cellular Physiology and Biochemistry
CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell
LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression - PMC
Inhibition of miRNA-1-Mediated Inflammation and Autophagy by Astragaloside IV Improves Lipopolysaccharide-Induced Cardiac Dysfunction in Rats
Journal
Journal of inflammation research
Selenium mitigates the inhibitory effect of TBBPA on NETs release by regulating ROS/MAPK pathways-induced carp neutrophil apoptosis and necroptosis
Journal
Fish & shellfish immunology
Ephrin type-B receptor 4 affinity chromatography: An effective and rapid method studying the active compounds targeting Ephrin type-B receptor 4.
Journal
Journal of chromatography. A
BPA exposure aggravates necroptosis of myocardial tissue in selenium deficient broilers through NO-dependent endoplasmic reticulum stress
The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model - PMC
Journal
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
Blockade of Store-operated Calcium Entry Sensitizes Breast Cancer Cells to Cisplatin Therapy via Modulating Inflammatory Response
Journal
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
Metabolomics combined with network pharmacology exploration reveals the modulatory properties of Astragali Radix extract in the treatment of liver fibrosis.
Electroacupuncture repairs intestinal barrier by upregulating CB1 through gut microbiota in DSS-induced acute colitis - PMC
Helicobacter pylori CagA Protein Regulating the Biological Characteristics of Gastric Cancer through the miR-155-5p/SMAD2/SP1 axis - PMC
Journal
Pathogens (Basel, Switzerland)
Shexiang Baoxin Pill Alleviates the Atherosclerotic Lesions in Mice via Improving Inflammation Response and Inhibiting Lipid Accumulation in the Arterial Wall.
Journal
Mediators of inflammation
The Comprehensive Analysis of N6-Methyadenosine Writer METTL3 and METTL14 in Gastric Cancer - PMC
Journal
Journal of oncology
miR-125a regulates HAS1 and inhibits the proliferation, invasion and metastasis by targeting STAT3 in non-small cell lung cancer cells
Journal
Journal of Cellular Biochemistry
MicroRNA-125a suppresses cell migration, invasion, and regulates hyaluronic acid synthase 1 expression by targeting signal transducers and activators of transcription 3 in renal cell carcinoma cells.
Journal
Journal of Cellular Biochemistry
ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway
dCas9guided demethylation of the AKT1 promoter improves milk protein synthesis in a bovine mastitis mammary gland epithelial model induced by using
Journal
Cell biology international
Super Enhancer Driven Hyaluronan Synthase 3 Promotes Malignant Progression of Nasopharyngeal Carcinoma - PMC
The involvement of lipid raft pathway in suppression of TGFβ-mediated metastasis by tolfenamic acid in hepatocellular carcinoma cells.
Journal
Toxicology and applied pharmacology
Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan
Journal
Pflugers Archiv : European Journal of Physiology
Low‐intensity pulsed ultrasound ameliorates erectile dysfunction induced by bilateral cavernous nerve injury through enhancing schwann cell‐mediated cavernous …
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy
Journal
Journal of atherosclerosis and thrombosis
Delivery of microRNA-423-5p by exosome from adipose-derived stem/stromal cells inhibits DVL3 to potentiate autologous fat graft survival through adipogenesis and
The function of BAP18 on modulation of androgen receptor action in luteinized granulosa cells from normal weight women with and without PCOS
Journal
Mol Cell Endocrinol
miR-125a restrains cell migration and invasion by targeting STAT3 in gastric cancer cells.
Journal
OncoTargets and therapy
Long noncoding RNA STXBP5-AS1 inhibits cell proliferation, migration, and invasion through inhibiting the PI3K/AKT signaling pathway in gastric cancer cells.
Journal
OncoTargets and therapy
Japanese Encephalitis Virus NS1' Protein Antagonizes Interferon Beta Production.
Species
Homo sapiens, Mus musculus
The prognostic and immunological role of FKBP1A in an integrated muti-omics cancers analysis, especially lung cancer
Journal
Journal of cancer research and clinical oncology
Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines - PMC
Journal
Drug design, development and therapy
Exosomes derived from human umbilical cord mesenchymal stem cells decrease neuroinflammation and facilitate the restoration of nerve function in rats
Journal
Molecular and cellular biochemistry
Andrographolide ameliorates bleomycin-induced pulmonary fibrosis by suppressing cell proliferation and myofibroblast differentiation of fibroblasts via the TGF-β1-mediated Smad-dependent and -independent pathways
Journal
Toxicology Letters
PINK1/Parkin-mediated mitophagy is activated to protect against AFB1-induced immunosuppression in mice spleen
Journal
Toxicology letters
Dynamic analysis of gene signatures in the progression of COPD - PMC
Tristetraprolin-RNA interaction map reveals a novel TTP-RelB regulatory network for innate immunity gene expression
Journal
Molecular Immunology
MiR-4953p attenuates cell pyroptosis and endometritis through inhibiting the activation of NLRP3 inflammasome in bovine
Journal
Molecular immunology
Extracellular vesicles derived from astrocytes facilitated neurite elongation by activating the Hippo pathway
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37
Journal
Experimental cell research
Senescent Fibroblasts Generate a CAF Phenotype through the Stat3 Pathway - PMC
SRSF6 regulates alternative splicing of genes involved in DNA damage response and DNA repair in HeLa cells
Bradykinin promotes proliferation, migration, and invasion of cervical cancer cells through STAT3 signaling pathways
CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway
Heat shock protein B7 (HSPB7) inhibits lung adenocarcinoma progression by inhibiting glycolysis - PMC
Layered Double
Hydroxide-Loaded miR-30a for the Treatment
of Breast Cancer In Vitro and In Vivo - PMC
Dauricine negatively regulates lipopolysaccharide- or cecal ligation and puncture-induced inflammatory response via NF-κB inactivation.
Journal
Archives of biochemistry and biophysics
FOXA2 suppresses gallbladder carcinoma cell migration, invasion, and epithelialmesenchymal transition by targeting SERPINB5
Journal
Environmental toxicology
MiR4943p aggravates pirarubicininduced cardiomyocyte injury by regulating MDM4/p53 signaling pathway
Journal
Environmental toxicology
Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA-183/135b-FOXO1/TXNIP/NLRP3 inflammasome axis
Journal
Environmental toxicology
Finding an efficient tetramethylated hydroxydiethylene of resveratrol analogue for potential anticancer agent
Valsartan prevents gefitinib-induced lung inflammation, oxidative stress, and alteration of plasma metabolites in rats - PMC
Journal
Saudi journal of biological sciences
Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells by sponging miR-1270 to activate the NF-B signaling pathway
Species
Cryptosporidium parvum
Design, synthesis, and biological evaluation of morpholinopyrimidine derivatives as anti-inflammatory agents - PMC
Upregulated bone morphogenetic protein 5 enhances proliferation and epithelial-mesenchymal transition process in benign prostatic hyperplasia via BMP/Smad signaling pathway
Species
Homo sapiens,Rattus norvegicus
Aminoguanidine alleviates gout in goslings experimentally infected with goose astrovirus-2 by reducing kidney lesions - PMC
Dietary bile acids improve breast muscle growth in chickens through FXR/IGF2 pathway
Modified rougan decoction attenuates hepatocyte apoptosis through ameliorating mitochondrial dysfunction by upregulated SIRT1/PGC-1 signaling pathway - PMC
MiR-940 promotes malignant progression of breast cancer by regulating FOXO3
IGF2BP2 maybe a novel prognostic biomarker in oral squamous cell carcinoma
Journal
Bioscience reports
Metformin induces M2 polarization via AMPK/PGC-1α/PPAR-γ pathway to improve peripheral nerve regeneration - PMC
Journal
American journal of translational research
ln RNA LINC01234 promotes triple-negative breast cancer progression through regulating the miR-429/SYNJ1 axis
Interleukin‐22 alleviates alcohol‐associated hepatic fibrosis, inhibits autophagy, and suppresses the PI3K/AKT/mTOR pathway in mice
Journal
Alcoholism, clinical and experimental research
Resveratrol ameliorates myocardial ischemia/reperfusion induced necroptosis through inhibition of the Hippo pathway
Journal
Journal of bioenergetics and biomembranes
Rutin protects against pirarubicin-induced cardiotoxicity by adjusting microRNA-125b-1-3p-mediated JunD signaling pathway
Journal
Molecular and Cellular Biochemistry
Vacuum plasma sprayed porous titanium coating on polyetheretherketone for ACDF improves the osteogenic ability: An in vitro and in vivo study
Journal
Biomed Microdevices
SIPA1 promotes angiogenesis by regulating VEGF secretion in Müller cells through STAT3 activation - PMC
Species
Homo sapiens,Mus musculus
Proton pump inhibitors affect sperm parameters by regulating aquaporins - PMC
Tanshinones suppress AURKA through up-regulation of miR-32 expression in non-small cell lung cancer
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
Depression-like behaviors in mouse model of Sjgren's syndrome: A role of gutmicrobiotabrain axis
Journal
Pharmacology, biochemistry, and behavior
Comprehensive Analysis of Prognosis and Immune Function of CD70-CD27 Signaling Axis in Pan-Cancer
Journal
Functional & integrative genomics
Emodin induced necroptosis in the glioma cell line U251 via the TNF-/RIP1/RIP3 pathway.
Journal
Investigational new drugs
Species
Homo sapiens, Mus musculus
Mitochondrial dysfunction resulting from the down-regulation of bone morphogenetic protein 5 may cause microtia
DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication
GPR27 Regulates Hepatocellular Carcinoma Progression via MAPK/ERK Pathway
Journal
Cancer management and research
Inhibition of Fatty Acid β-Oxidation by Fatty Acid Binding Protein 4 Induces Ferroptosis in HK2 Cells Under High Glucose Conditions - PMC
Journal
Endocrinology and metabolism (Seoul, Korea)
Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype (SK2) in Mice
LIFU Alleviates Neuropathic Pain by Improving the KCC 2 Expression and Inhibiting the CaMKIV-KCC 2 Pathway in the L4-L5 Section of the Spinal Cord
Indocyanine Green Based Photodynamic Therapy for Keloids: Fundamental Investigation and Clinical Improvement
Journal
Photodiagnosis and photodynamic therapy
Sirt1 Regulates Oxidative Stress in Oxygen-Glucose Deprived Hippocampal Neurons
FGD1 Variant Associated With Aarskog-Scott Syndrome - PMC
Journal
Frontiers in pediatrics
miR-26a-5p Regulates Adipocyte Differentiation via Directly Targeting ACSL3 in Adipocytes - PMC
Clinical and genetic characteristics of Chinese patients with reducing body myopathy
Journal
Neuromuscul Disord
THE IL-33/ST2 AXIS PROMOTES ACUTE RESPIRATORY DISTRESS SYNDROME BY NATURAL KILLER T CELLS - PMC
Journal
Shock (Augusta, Ga.)
Fentanyl enhances HIV infection in vitro
Caffeic Acid Phenethyl Ester (CAPE) Improves Boar Sperm Quality and Antioxidant Capacity in Liquid Preservation (17°C) Linked to AMPK Activity Maintenance - PMC
Journal
Frontiers in veterinary science
Design, synthesis, and biological evaluation of 2-(naphthalen-1-yloxy)-N-phenylacetamide derivatives as TRPM4 inhibitors for the treatment of prostate cancer
Journal
Bioorganic & medicinal chemistry
Synthesis of nature product kinsenoside analogues with anti-inflammatory activity
Journal
Bioorganic & medicinal chemistry
MicroRNA‑138‑5p drives the progression of heart failure via inhibiting sirtuin 1 signaling
Silencing activating transcription factor 2 promotes the anticancer activity of sorafenib in hepatocellular carcinoma cells
Journal
Molecular medicine reports
miR-613 inhibits the proliferation of human ovarian granulosa cells by arresting cell cycle progression via the targeting of IGF-1
Journal
Molecular medicine reports
Inefficient ATP synthesis by inhibiting mitochondrial respiration causes lipids to decrease in MSTN-lacking muscles of loach Misgurnus anguillicaudatus.
Journal
Functional & integrative genomics
Inefficient ATP synthesis by inhibiting mitochondrial respiration causes lipids to decrease in MSTN-lacking muscles of loach Misgurnus anguillicaudatus.
Journal
Functional & integrative genomics
ZIP14 is degraded in response to manganese exposure
Novel mutations in ZP2 and ZP3 cause female infertility in three patients
Journal
Journal of assisted reproduction and genetics
Electroacupuncture Relieves Visceral Hypersensitivity via Balancing PAR2 and PAR4 in the Descending Pain Modulatory System of Goats - PMC
Depletion of chop suppresses procedural apoptosis and enhances innate immunity in loach Misgurnus anguillicaudatus under ammonia nitrogen stress
Journal
Journal of animal science
Species
Cobitis taenia Linnaeus
MiR-135b promotes HCC tumorigenesis through a positive-feedback loop
Journal
Biochem Biophys Res Commun
Inhibition of TBK1 reduces choroidal neovascularization in vitro and in vivo
Journal
Biochemical and biophysical research communications
MiR-3960 inhibits bladder cancer progression via targeting of DEXI
Journal
Biochemical and biophysical research communications
Species
Homo sapiens, Mus musculus
Angiotensin-(1-7) suppresses airway inflammation and airway remodeling via inhibiting ATG5 in allergic asthma - PMC
Journal
BMC pulmonary medicine
Chemokine (C-C motif) Ligand 6 Aggravates Hypoxia Reoxygenation-induced Apoptosis in H9c2 Cells Through Enhancing the Expression of Insulin-like Growth Factor 2-Antisense
Journal
Journal of cardiovascular pharmacology
GREM1 is a potential biomarker for the progression and prognosis of bladder cancer - PMC
Journal
World journal of surgical oncology
Risk of Developing Hepatocellular Carcinoma following Depressive Disorder Based on the Expression Level of Oatp2a1 and Oatp2b1.
Journal
BioMed research international
Ghrelin Ameliorates Angiotensin II-Induced Myocardial Fibrosis by Upregulating Peroxisome Proliferator-Activated Receptor Gamma in Young Male Rats.
Journal
BioMed Research International
Exploratory metabolomic analysis based on UHPLC-Q-TOF-MS/MS to study hypoxia-reoxygenation energy metabolic alterations in HK-2 cells - PMC
Virtual screening based identification of miltefosine and octenidine as inhibitors of heat shock protein 90
Journal
Naunyn Schmiedebergs Arch Pharmacol
Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis
Journal
Journal of Natural Medicines
Ferrostatin-1 Ameliorates Bupivacaine-Induced Spinal Neurotoxicity in rats by Inhibiting Ferroptosis
Journal
Neuroscience letters
Lack of miRNA-17 family mediates high glucose-induced PAR-1 upregulation in glomerular mesangial cells
Journal
Naunyn-Schmiedeberg's archives of pharmacology
L-fucose ameliorates the carcinogenic properties of Fusobacterium nucleatum in colorectal cancer
MicroRNA-27b-3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP-13
SOCS2 is a potential prognostic marker that suppresses the viability of hepatocellular carcinoma cells
Moderate mechanical stimulation antagonizes inflammation of annulus fibrosus cells through YAP‐mediated suppression of NF‐κB signaling
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
PAIP1 regulates expression of immune and inflammatory response associated genes at transcript level in liver cancer cell - PMC
Isopsoralen suppresses receptor activator of nuclear factor kappa-β ligand-induced osteoclastogenesis by inhibiting the NF-κB signaling - PMC
FGF19 promotes cell autophagy and cisplatin chemoresistance by activating MAPK signaling in ovarian cancer - PMC
Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC - PMC
Chrysophanol Suppresses Cell Growth via mTOR/PPAR-α Regulation and ROS Accumulation in Cultured Human Tongue Squamous Carcinoma SAS Cells - PMC
Journal
Current issues in molecular biology
Anti-fibrotic actions of Ghrelin by inhibition of the NADPH oxidase-ROS signaling pathway
Journal
clinical and experimental pharmacology and physiology
Metabotropic Glutamate Receptor 5 Blockade Attenuates Pathological Cardiac Remodeling in Pulmonary Arterial Hypertension
Journal
Clinical and experimental pharmacology & physiology
Exosomes Derived from Adipose Mesenchymal Stem Cells Restore Functional Endometrium in a Rat Model of Intrauterine Adhesions
Journal
Reproductive Sciences (Thousand Oaks, Calif.)
Expression patterns of ZO-1/2 and their effects on porcine oocyte in vitro maturation and early embryonic development
miR-148b-3p, miR-190b, and miR-429 Regulate Cell Progression and Act as Potential Biomarkers for Breast Cancer.
Journal
Journal of Breast Cancer
ZnSO4 Protects against premature ovarian failure through PI3K/AKT/GSK3β signaling pathway
TEAD1 Silencing Regulates Cell Proliferation and Resistance to 5-Fluorouracil in Cutaneous Squamous Cell Carcinoma - PMC
Journal
Clinical, cosmetic and investigational dermatology
miR-34a regulates adipogenesis in porcine intramuscular adipocytes by targeting ACSL4
High glucose up‐regulates PAR‐1 in SH‐SY5Y cells via deficiency of miR‐20a and miR‐190a
Journal
Fundam Clin Pharmacol
Effects of temperature control on hyperthermia-related cardiac dysfunction in a porcine model of cardiac arrest
Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1 - PMC
Journal
Journal of orthopaedic surgery and research
Bufei Decoction Improves Lung-Qi Deficiency Syndrome of Chronic Obstructive Pulmonary Disease in Rats by Regulating the Balance of Th17/Treg Cells - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Flavonoid Extract from Propolis Provides Cardioprotection following Myocardial Infarction by Activating PPAR-γ - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production
Journal
Current medical science
Species
Homo sapiens, Mus musculus
GATA4 inhibits odontoblastic differentiation of dental pulp stem cells through targeting IGFBP3
Journal
Archives of oral biology
CCL26 silence represses colon cancer by inhibiting the EMT signaling pathway
H19 regulates angiogenic capacity of extravillous trophoblasts by H19/miR-106a-5p/VEGFA axis
Journal
Archives of Gynecology and Obstetrics
Mechanism of Rhodiola rosea-Euonymus alatus drug pair against rheumatoid arthritis: Network pharmacology and experimental validation - PMC
Journal
Immunity, inflammation and disease
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
RP11-79H23. 3 Inhibits the Proliferation and Metastasis of Non-small-cell Lung Cancer Through Promoting miR-29c
Journal
Biochemical genetics
Identification of ADAM23 as a Potential Signature for Psoriasis Using Integrative Machine-Learning and Experimental Verification - PMC
Journal
International journal of general medicine
The coexistence of a novel WNK1 variant and a copy number variation causes hereditary sensory and autonomic neuropathy type IIA.
Journal
BMC medical genetics
Vitamin E Reversed Apoptosis of Cardiomyocytes Induced by Exposure to High Dose Formaldehyde During Mice Pregnancy
Journal
International heart journal
Effect of Xanthii Fructus alcohol extract on proliferation and apoptosis of HFLS-RA and its mechanism - PMC
SH3BP1 Regulates Melanoma Progression Through Race1/Wace2 Signaling
Pathway - PMC
Journal
Clinical Medicine Insights. Oncology
Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells
Journal
Ultrastructural pathology
Regulation of dynamin-related protein 1 (DRP1) levels modulates myoblast atrophy induced by C26 colon cancer-conditioned medium
Journal
Translational cancer research
Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression - PMC
Journal
Cell death & disease
CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN
Journal
Journal of receptor and signal transduction research
The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer - PMC
Journal
Cell death & disease
Species
Homo sapiens, Mus musculus
Tau reduction attenuates autism-like features in Fmr1 knockout mice - PMC
Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance - PMC
Journal
Cell regeneration (London, England)
B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma - PMC
Journal
Journal of experimental & clinical cancer research : CR
ENPP1 ameliorates vascular calcification via inhibiting the osteogenic transformation of VSMCs and generating PPi - PMC
Journal
Open medicine (Warsaw, Poland)
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING
The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture - PMC
Journal
bioRxiv : the preprint server for biology
ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma - PMC
Journal
Journal of experimental & clinical cancer research : CR
ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma - PMC
Journal
Journal of experimental & clinical cancer research : CR
Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion - PMC
Journal
Cell death & disease
FIBP is a prognostic biomarker and correlated with clinicalpathological characteristics and immune infiltrates in acute myeloid leukemia - PMC
Journal
Discover. Oncology
Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma
Journal
Discover. Oncology
lncRNA-AC130710/miR-129-5p/mGluR1 axis promote migration and invasion by activating PKCα-MAPK signal pathway in melanoma - PMC
Journal
Open medicine (Warsaw, Poland)
Multifunctional Biodegradable Prussian Blue Analogue for Synergetic Photothermal/Photodynamic/Chemodynamic Therapy and Intrinsic Tumor Metastasis Inhibition
Journal
ACS applied bio materials
Nitazoxanide and JIB-04 have broad-spectrum antiviral activity and inhibit SARS-CoV-2 replication in cell culture and coronavirus pathogenesis in a pig model
A NIR fluorescent smart probe for imaging tumor hypoxia
Journal
Cancer Rep (Hoboken)