ABflo® 647 Rat anti-Mouse CD16/CD32 mAb (A28570)
- 反应物种：Mouse
- 验证应用：FC
- 同 种 型：IgG2b, κ
详细信息
推荐稀释比
- FC≤0.25 µg per million cells in 100 µl volume
浓度查询
请输入产品标签上的lot号，例如4000000001
免疫原
This information is considered to be commercially sensitive.
偶联物
ABflo® 647. Ex:648nm. Em:664nm.
偶联物
ABflo® 647. Ex:648nm. Em:664nm.
细胞定位
Cell membrane ; Single-pass type I membrane protein, Cytoplasm, cytoskeleton, Secreted.
存储缓冲液
Store at 2-8℃. Avoid freeze.
Buffer: PBS with 0.09% Sodium azide, 0.2% BSA, pH7.3.
纯化方式
Affinity purification
背景信息
CD16 is a 50-65 kDa cell surface molecule that exists in two isoforms: a transmembrane form expressed by natural killer (NK) cells, and a glycosylphosphatidylinositol (GPI)-anchored form expressed by granulocytes. It serves as a low-affinity receptor for IgG (FcγRIII) and is a critical mediator of antibody-dependent cellular cytotoxicity (ADCC) by NK cells.
CD32 (Fcgr2) is a 40 kD transmembrane glycoprotein, member of the immunoglobulin superfamily. The extracellular region of CD32 consists of two Ig C-type domains that binds the Fc region from monomeric IgG with low affinity, but binds immune complexes efficiently. CD32 can mediate phagocytosis of immune complexes and modulate cell activation. CD32 is expressed by Macrophages, neutrophils, mast cells and B cells.
别名
CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; Fc[g]RII; F630109E10Rik; CD16
