Flow Cytometry analysis of human PBMCs, using ABflo® 610 Rabbit anti-Human/Monkey CD4 mAb (A26218, dilution 1:25), ABflo® 500 Rabbit anti-Human/Monkey CD8a mAb (A26731, dilution 1:25), and other antibodies. ABclonal antibodies demonstrated superior discrimination of the CD8low T cell subset in PBMCs compared to Vendor B's comparable antibodies.
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背景信息
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
