Recombinant protein (or fragment).This information is considered to be commercially sensitive.
克隆号
ARC55292
产品形式
Liquid
偶联物
ABflo® 594. Ex:588nm. Em:604nm.
克隆号
ARC55292
产品形式
Liquid
偶联物
ABflo® 594. Ex:588nm. Em:604nm.
细胞定位
Plasma membrane, plasma membrane raft.
存储缓冲液
Store at 2-8℃. Avoid freeze. Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
