ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
浓度查询
请输入产品标签上的lot号,例如4000000001
免疫原
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
理论分子量
139kDa
实际分子量
139kDa
克隆号
ARC63314
产品形式
Liquid
偶联物
Unconjugated
理论分子量
139kDa
实际分子量
139kDa
克隆号
ARC63314
产品形式
Liquid
偶联物
Unconjugated
阳性样本
ALPK1 knockout (KO) 293T cells transfected with Mouse ALPK1
细胞定位
Cytoplasm, cytoskeleton.
存储缓冲液
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
α- Protein Kinase 1, also known as α- ALPK1 is associated with chronic kidney disease (CKD), myocardial infarction, gout and type 2 diabetes. According to reports, ALPK1 mutations can lead to serious deficits in motor coordination in mice. ALPK1 can enhance the expression of pro-inflammatory cytokines, including IL-1, in cultured human THP1 and human embryonic kidney 293 (HEK293) cells (PMID: 31557402, PMID: 26275947) β、 IL-8 and TGF- β 1. The ALPK1 short subtype (108 kDa) is highly expressed in the brain, spinal cord, heart, lungs, spleen, thymus, small intestine, skin, and testes, while detecting skeletal muscle and kidney. ALPK1 isoform (130 kDa) appears in the heart, lungs, thymus, and skin. As a novel innate immune receptor, ALPK1 can recognize bacteria-derived small molecule ADP-heptose and activate the immune response (PubMed: 30111836, PubMed: 30111836)