Flow cytometry analysis of human PBMCs using ABflo® 647 Rabbit anti-Human PD-L1/CD274 mAb and ABflo® 488 Rabbit anti-Human TIM-3/HAVCR2 mAb clearly classified positive and negative cells.
Flow cytometry analysis of human PBMCs using ABflo® 488 Rabbit anti-Human TIM-3/HAVCR2 monoclonal antibody clearly classified positive and negative cells.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
