Recombinant Human ERK2/MAPK1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 66 kDa.
Immobilized Recombinant Human ERK2/MAPK1 Protein at 1μg/mL (100 μL/well) can bind ERK1/2 Rabbit mAb with a linear range of 0.017-4.92 ng/mL.
ERK2 is a protein serine/threonine kinase, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions.
