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SARS-CoV-2 Nucleocapsid Protein Sanwich ELISA Immunoassay
Recommended Concentration | Sample | |
---|---|---|
ELISA Capture | 1-4ug/mL | Rabbit anti-SARS-CoV-2 Nucleocapsid Protein mAb(CAP/DET)(Cat. No. RM17615) |
ELISA Detection | 0.05-0.2ug/mL | Rabbit anti-SARS-CoV-2 Nucleocapsid Protein mAb(DET)(Cat. No. RM17617) |
Standard | 78-5000pg/mL | Recombinant SARS-CoV-2 Nucleocapsid Protein with His tag(Cat. No. RP01281) |
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.