产品中心 / 产品类型 / ELISA试剂盒 / ELISA 抗体对

Rabbit anti-SARS-CoV-2 Spike S1 Protein mAb(CAP) (RM17611)

货号: RM17611
促销价:   ¥1260
抗体定制服务咨询

文献引用 (0)

详细信息

产品名称
Rabbit anti-SARS-CoV-2 Spike S1 Protein mAb(CAP)
货号
RM17611
免疫原
HK293 derived SARS-CoV-2 SPIKE S1
Val16-Arg685
Accession #YP_009724390.1
纯化方式
Affinity purification
同种型
Rabbit IgG
内毒素水平
< 1.0 EU/μg of the protein by LAL method.
存储溶液
Supplied as a 0.2um filtered solution in PBS with 0.1%Braveds MB-1,PH 7.4.
CrossReactivity
Has cross-reactivity in ELISA with
SARS-CoV Spike S1 Protein (Cat# RP01265)
SARS-CoV Spike RBD Protein (Cat# RP01258)
No cross-reactivity in ELISA with
MERS-CoV Spike S1 Protein
存储条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative:0.1%Braveds MB-1 Avoid repeated freeze-thaw cycles.

* This package insert must be read in its entirety before using this product.

应用

SARS-CoV-2 Spike S1 Sanwich ELISA Immunoassay

 Recommended
Concentration
Sample
ELISA Capture1-4ug/mLRabbit anti-SARS-CoV-2 Spike S1 Protein mAb(CAP) (Cat. No. RM17611)
ELISA Detection0.05-0.2ug/mLRabbit anti-SARS-CoV-2 Spike S1 Protein mAb(DET) (Cat. No. RM17612)
Standard156-10000pg/mLRecombinant SARS-COV-2 Spike S1 Protein with His tag(Cat. No. RP01262)

背景信息

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It''s been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.

>